Yearly Archives: 1997

Glucose metabolism defect in rare form of Type 2 diabetes revealed

A defect in a gene recently linked to a rare inherited form of Type 2 diabetes impairs the pathway that breaks down blood sugar and provides the main signal for insulin secretion in the pancreas, report researchers at The Rockefeller University in the Nov. 25 Proceedings of the National Academy of Sciences. This work provides the first insight into the molecular mechanism of this disease and opens new avenues for developing better therapies to treat more common forms of late-onset diabetes. More »

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Plant-Based Therapies Examined for Colon Cancer Prevention

Three therapies derived from plants will be tested at The Rockefeller University in New York City for their ability to prevent colorectal cancer, which afflicts some 150,000 Americans each year. The compounds have the potential to be safer than cancer-thwarting nonsteroidal antiinflammatory drugs (NSAIDs), widely used aspirin-like drugs known to prevent colorectal cancer as well as reduce related deaths by half. More »

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Hunt for Early Heart Attack Genes Begins

More than 2,000 people will be enrolled in a hunt for the genetic causes that underlie “early” heart attacks that strike men and women in middle age. The study is part of the research program of the Starr Center for Human Genetics at The Rockefeller University in New York City. More »

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Mutated Gene Causes Death of Nerves in Brain

A gene responsible for the degeneration and death of certain nerve cells in the brain has been cloned, yielding information that may be useful for further studies of such neurodegenerative diseases as Alzheimer’s and Parkinson’s, investigators from the Howard Hughes Medical Institute at The Rockefeller University and from The Johns Hopkins School of Medicine report in the Aug. 21 Nature. More »

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Resistance to Leptin Contributes to Obesity

Insensitivity to the protein leptin, which helps the body regulate its fat stores, contributes to obesity in mice according to the first formal study of leptin intolerance, report scientists in the Aug. 5 Proceedings of the National Academy of Sciences. The findings also provide clues about leptin’s action in the nervous system and may help to explain some forms of obesity that affect humans, including more than 50 million overweight adult Americans, the researchers note. More »

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Rockefeller University Honors William O. Baker, Presents Honorary Degrees to Irene Diamond and Christian de Duve and Awards 21 Doctorates at Graduation Ceremonies

The Rockefeller University will honor William O. Baker, Ph.D., former chairman of the board of AT&T Bell Laboratories, Inc., and award honorary doctoral degrees to philanthropist Irene Diamond and Nobel Prize winner Christian de Duve, Ph.D., M.D., at the institution’s 39th commencement exercises, Thursday, June 12, 1997. More »

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Lewis Thomas Prize Honors Max Perutz

Nobel laureate, molecular biologist and author Max Perutz, Ph.D., is the recipient of the 1997 Lewis Thomas Prize, which honors scientists for their literary achievements and is awarded by The Rockefeller University. More »

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Altered Gene Increases Men’s Risk for Obsessive-Compulsive Disorder

Possessing an altered form of a gene involved in the communication between the brain’s nerve cells may put certain men at greater risk of developing obsessive-compulsive disorder (OCD), report scientists from The Rockefeller University and four other institutions in the April 29 Proceedings of the National Academy of Sciences. The discovery, the first susceptibility gene isolated for OCD, offers a possible target for developing treatments for the disorder, which affects 1 to 3 percent of the U.S. population. More »

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Scientists Determine 3-D Crystal Structure of Cancer-causing Protein

The three-dimensional picture of a cancer-causing protein illuminates how a mutated gene transforms cells into cancer, report scientists from the Howard Hughes Medical Institute at The Rockefeller University in the Feb. 13 Nature. The determination of this structure clarifies earlier models that sought to explain how the gene, called src, works and offers new information for designing drug therapies to fight cancers. More »

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Marker Helps Identify Children at Risk for Obsessive-Compulsive Disorder Following Streptococcal Infections

A biological marker may identify children at risk for developing obsessive-compulsive disorder (OCD) after having an untreated streptococcal bacteria infection, according to scientists from The Rockefeller University and the National Institute of Mental Health (NIMH). The discovery will help improve the understanding of the disease process of OCD and related tic disorders such as Tourette’s syndrome. More »

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