Yearly Archives: 2011

Nature Immunology: December 25, 2011

Nature Immunology online: December 25, 2011 B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen Irene Puga, Montserrat Cols, Carolina M. Barra, Bing He, Linda Cassis, Maurizio Gentile, Laura Comerma, Alejo Chorny, … More »

Cell 147: 1615–1627 (December 23, 2011)

Cell 147: 1615–1627 The functional organization of cutaneous low-threshold mechanosensory neurons Lishi Li, Michael Rutlin, Victoria E. Abraira, Colleen Cassidy, Laura Kus, Shiaoching Gong, Michael P. Jankowski, Wenqin Luo, Nathaniel Heintz, H. Richard Koerber, C. Jeffery Woodbury and  David D. Ginty Here, we report genetic labeling … More »

Science 344: 1675-1680

Science 344: 1675–1680 How a DNA polymerase clamp loader opens a sliding clamp Brian A. Kelch, Debora L. Makino, Mike O’Donnell and John Kuriyan We present structures for the ATP-bound state of the clamp loader complex from bacteriophage T4, bound … More »

In the News — NYT

“But the rule against posthumous awards has now been violated several times — most recently this month, when the prize in medicine was given to the widow of Dr. Ralph M. Steinman, a scientist at Rockefeller University in Manhattan who died … More »

In cancer, molecular signals that recruit blood vessels also trigger metastasis

Cancer cells are most deadly when they’re on the move – able not only to destroy whatever organ they are first formed in, but also to create colonies elsewhere in the body. New research has now shown how a small RNA prevents the recruitment and formation of blood vessels near cancer cells destined to become metastases, a process that must occur in order for them to grow. The scientists say that if drugs could be developed that act on the pathways regulated by this microRNA, they might be able to block the metastatic process and prevent some breast cancers from becoming deadly. More »

Tags: , ,

Nature online: December 14, 2011

Nature online: December 14, 2011 A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells Kim J. Png, Nils Halberg, Mitsukuni Yoshida and Sohail F. Tavazoie Here we reveal that endogenous miR-126, an miRNA silenced in a variety … More »

Nature Genetics: December 11, 2011

Nature Genetics online: December 11, 2011 Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome Carine Le Goff, Clémentine Mahaut, Avinash Abhyankar, Wilfried Le Goff, Valérie Serre, Alexandra Afenjar, Anne Destrée, Maja di Rocco, … More »

2011 Nobel Prize Ceremony to be webcast live

Tomorrow, the family of Nobel Prize winner Ralph M. Steinman, who died September 30, will accept the Nobel medal and diploma on his behalf from King Carl XVI Gustaf of Sweden. The ceremony will be Webcast live beginning at 10:20 a.m. Eastern Time. A video of the Nobel Prize Award Ceremony will also be available a few days later. More »

Tags: , ,

Nature online: December 4, 2011

Nature online: December 4, 2011 Open Structure of the Ca(2+) Gating Ring in the High-conductance Ca(2+)-activated K(+) Channel Peng Yuan, Manuel D. Leonetti, Yichun Hsiung and Roderick MacKinnon Here we present the Ca(2+)-bound conformation of the gating ring. This structure … More »

Resident protection

To keep the body safe, the immune system enlists more than one form of protection. Rockefeller University scientists, working in collaboration with researchers at New York University, are learning about an important, but little-known, network of dendritic cells in lymph nodes through innovative, live-action imaging. More »

Tags: , ,

In the News

Yale Environment 360 The New Story of Stuff: Can We Consume Less? “Optimists such as Jesse Ausubel, director of the Program for the Human Environment at The Rockefeller University in New York, see a long-term and unstoppable trend that is … More »

Cell online: November 30, 2011

Cell online: November 30, 2011 Structural Basis for Promoter −10 Element Recognition by the Bacterial RNA Polymerase σ Subunit Andrey Feklistov and Seth A. Darst We determined crystal structures of σ domain 2 bound to single-stranded DNA bearing -10 element sequences. The … More »

Nature online: November 27, 2011

Nature online: November 27, 2011 GlcNAcylation of Histone H2B Facilitates its Monoubiquitination Ryoji Fujiki, Waka Hashiba, Hiroki Sekine, Atsushi Yokoyama, Toshihiro Chikanishi, Saya Ito, Yuuki Imai, Jaehoon Kim, Housheng Hansen He, Katsuhide Igarashi, Jun Kanno, Fumiaki Ohtake, Hirochika Kitagawa, Robert … More »

Immunity 35: 819–831 (November 23, 2011)

Immunity 35: 819–831 Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis Jae-Hoon Choi, Cheolho Cheong, Durga B. Dandamudi, Chae Gyu Park, Anthony Rodriguez, Saurabh Mehandru, Klara Velinzon, In-Hyuk Jung, Ji-Young Yoo, Goo Taeg Oh and Ralph M. Steinman Early events in … More »

Statin-intolerant patients need a different type of clinical trial, Rockefeller researchers say

Although only five percent of people in clinical trials report side effects from statin drugs, in practice the problem is far greater. Clinical trials need to better address the needs of statin-intolerant patients, Rockefeller researchers say. More »

In the News

“Sir Paul Nurse, 62, has the effusive and infectious enthusiasm of a natural leader who, it is obvious, leads by example rather than threat. By his own admission, he has an idealistic view of science ‘as a liberalising and progressive … More »

Nature online: November 13, 2011

Nature online: November 13, 2011 Structure of full-length Drosophila cryptochrom Brian D. Zoltowski, Anand T. Vaidya, Deniz Top, Joanne Widom, Michael W. Young and Brian R. Crane Here, we report a 2.3-Å resolution crystal structure of Drosophila CRY with an intact C terminus. The … More »

In the News

93-Year-Old Wins Prestigious Science Award “At 93-years-old, Brenda Milner is responsible for some of the biggest discoveries in the science of memory. And she’s still working today, at McGill University in Montreal, Canada. She’s also the winner of the prestigious Pearl Meister … More »

In the News

‘Nosy’ and Observant, a Neuroscientist Continues Her Memorable Career at 93 “Psychology students who read about Brenda Milner’s seminal work with amnesia patients nearly 60 years ago might not suspect that she is, at 93, still engaged full time in … More »

University joins 10 leading medical and research institutions to form New York Genome Center

The New York Genome Center, which will become one of the largest genomic facilities in North America, will begin operations as early as spring 2012 in its 120,000 square foot Manhattan facility.
More »