Nature online: November 27, 2011
GlcNAcylation of Histone H2B Facilitates its Monoubiquitination
Ryoji Fujiki, Waka Hashiba, Hiroki Sekine, Atsushi Yokoyama, Toshihiro Chikanishi, Saya Ito, Yuuki Imai, Jaehoon Kim, Housheng Hansen He, Katsuhide Igarashi, Jun Kanno, Fumiaki Ohtake, Hirochika Kitagawa, Robert G. Roeder, Myles Brown and Shigeaki Kato
In a genome-wide analysis, H2B S112 GlcNAcylation sites were observed widely distributed over chromosomes including transcribed gene loci, with some sites co-localizing with H2B K120 monoubiquitination. These findings suggest that H2B S112 GlcNAcylation is a histone modification that facilitates H2BK120 monoubiquitination, presumably for transcriptional activation.