Nature online: December 14, 2011
A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells
Kim J. Png, Nils Halberg, Mitsukuni Yoshida and Sohail F. Tavazoie
Here we reveal that endogenous miR-126, an miRNA silenced in a variety of common human cancers, non-cell-autonomously regulates endothelial cell recruitment to metastatic breast cancer cells, in vitro and in vivo. Through loss-of-function and epistasis experiments, we delineate an miRNA regulatory network’s individual components as novel and cell-extrinsic regulators of endothelial recruitment, angiogenesis and metastatic colonization.