Science 344: 1675-1680

Science 344: 1675–1680
How a DNA polymerase clamp loader opens a sliding clamp
Brian A. Kelch, Debora L. Makino, Mike O’Donnell and John Kuriyan

We present structures for the ATP-bound state of the clamp loader complex from bacteriophage T4, bound to an open clamp and primer-template DNA. The structures explain how synergy among the loader, the clamp, and DNA can trigger ATP hydrolysis and release of the closed clamp on DNA.

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