Science 344: 1675–1680
How a DNA polymerase clamp loader opens a sliding clamp
Brian A. Kelch, Debora L. Makino, Mike O’Donnell and John Kuriyan
We present structures for the ATP-bound state of the clamp loader complex from bacteriophage T4, bound to an open clamp and primer-template DNA. The structures explain how synergy among the loader, the clamp, and DNA can trigger ATP hydrolysis and release of the closed clamp on DNA.