Yearly Archives: 2012

Cell 151: 1005-1016 (11-21-12)

Cell 151: 1005-1016 Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein Joseph Osmundson, Cristina Montero-Diez, Lars F. Westblade, Ann Hochschild and Seth A. Darst

Neuron 76: 735-749 (11-21-12)

Neuron 76: 735-749 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing Patricia T. Yam, Christopher B. Kent, Steves Morin, W. Todd Farmer, Ricardo Alchini, Léa Lepelletier, David R. Colman, Marc Tessier-Lavigne, … More »

Cell 151: 1068-1082 (11-21-12)

Cell 151: 1068-1082 Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis Nora Pencheva, Hien Tran, Colin Buss, Doowon Huh, Marija Drobnjak, Klaus  Busam and Sohail F. Tavazoie

Proceedings of the National Academy of Sciences USA 109: E3268-3277 (11-20-12)

Proceedings of the National Academy of Sciences USA 109: E3268-3277 Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies Hugo Mouquet, Louise Scharf, Zelda Euler, Yan Liu, Caroline Eden, Johannes F.  Scheid, Ariel Halper-Stromberg, Priyanthi N. P. Gnanapragasam, Daniel I. … More »

Proceedings of the National Academy of Sciences USA 109: 19274-19279 (11-20-12)

Proceedings of the National Academy of Sciences USA 109: 19274-19279 Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel Manuel D. Leonetti, Peng Yuan, Yichun Hsiung and Roderick MacKinnon

Brain displays an intrinsic mechanism for fighting infection

Researchers in the St. Giles Laboratory of Human Genetics of Infectious Diseases have shed light on how a genetic defect leaves some children susceptible to a rare and damaging brain infection and have found evidence of an intrinsic immune mechanism in the brain that fights the viral infection in healthy people. More »

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Molecular Cell online: November 8, 2012

Molecular Cell online: November 8, 2012 Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting Gabriel B. Loeb, Aly A. Khan, David Canner, Joseph B. Hiatt, Jay Shendure, Robert B. Darnell, Christina S. Leslie and Alexander Y. Rudensky

Potent antibodies neutralize HIV and could offer new therapy, study finds

Rockefeller researchers in Michel Nussenzweig’s Laboratory of Molecular Immunology have found that a newly-discovered class of especially potent antibodies is effective at neutralizing HIV infection in mice for a 60 day period, longer than current antiretroviral drugs which require daily application. The antibodies, which suppressed the virus when used in combination, could one day be given to humans to treat the disease. More »

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Nature Immunology online: October 28, 2012

Nature Immunology online: October 28, 2012 Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency Bertrand Boisson, Emmanuel Laplantine, Carolina Prando, Silvia Giliani, Elisabeth  Israelsson, Zhaohui Xu, Avinash Abhyankar, Laura Israël, Giraldina  Trevejo-Nunez, Dusan Bogunovic, Alma-Martina Cepika, … More »

Nature online: October 28, 2012

Nature online: October 28, 2012 Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells Fabien G. Lafaille, Itai M. Pessach, Shen-Ying Zhang, Michael J. Ciancanelli, Melina Herman, Avinash Abhyankar, Shui-Wang Ying, Sotirios Keros, Peter A.  Goldstein, Gustavo Mostoslavsky, … More »

Science online: October 26, 2012

Science online: October 26, 2012 Oxytocin/ vasopressin-related peptides have an ancient role in reproductive behavior Jennifer L. Garrison, Evan Z. Macosko, Samantha Bernstein, Navin Pokala, Dirk  R. Albrecht and Cornelia I. Bargmann

Nicholson Lecture brings vascular biologist to speak at Rockefeller as part of exchange program with Karolinska Institute

Christer Betsholtz will visit the Rockefeller University campus as part of a recently renewed program that supports research exchanges between the university and the Karolinska Institute. Betsholtz studies vascular biology, with a focus on cellular and molecular mechanisms for angiogenesis and vascular permeability. More »

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Neurotransmitters linked to mating behavior are shared by mammals and worms

New research from Rockefeller University has shown that chemicals in the brain — neuropeptides known as vasopressin and oxytocin — play a role in coordinating mating and reproductive behavior in animals ranging from humans to fish to invertebrates. More »

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Nature online: October 24, 2012

Nature online: October 24, 2012 HIV therapy by a combination of broadly neutralizing antibodies in humanized mice Florian Klein, Ariel Halper-Stromberg, Joshua A. Horwitz, Henning Gruell, Johannes F. Scheid, Stylianos Bournazos, Hugo Mouquet, Linda A. Spatz, Ron  Diskin, Alexander Abadir, … More »

Proceedings of the National Academy of Sciences USA 109: 17657-17662 (10-23-12)

Proceedings of the National Academy of Sciences USA 109: 17657-17662 Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response Richard G. Hunter, Gen Murakami, Scott Dewell, Ma’ayan Seligsohn, Miriam  E.R. Baker, Nicole A. Datson, Bruce S. … More »

Nature Genetics 44: 1255-1259 (10-21-12)

Nature Genetics 44: 1255-1259 De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy Giulia Barcia, Matthew R Fleming, Aline Deligniere, Valeswara-Rao Gazula, Maile  R Brown, Maeva Langouet, Haijun Chen, Jack Kronengold, Avinash Abhyankar, Roberta Cilio, Patrick … More »

Cell Host and Microbe 12: 585-597 (10-18-12)

Cell Host and Microbe 12: 585-597 Inhibition of HIV-1 particle assembly by 2′,3′-cyclic-nucleotide 3′-phosphodiesterase Sam J. Wilson, John W. Schoggins, Trinity Zang, Sebla B. Kutluay, Nolwenn Jouvenet, Mudathir A. Alim, Julia Bitzegeio, Charles M. Rice and Paul D. Bieniasz

Neuron 76: 338-352 (10-18-12)

Neuron 76: 338-352 Slit/Robo signaling modulates the proliferation of central nervous system progenitors Víctor Borrell, Adrián Cárdenas, Gabriele Ciceri, Joan Galcerán, Nuria Flames, Ramón Pla, Sandrina Nóbrega-Pereira, Cristina  García-Frigola, Sandra Peregrín, Zhen Zhao, Le Ma, Marc Tessier-Lavigne and Oscar Marín

Nature online: October 17, 2012

Nature online: October 17, 2012 DAXX envelops an H3.3-H4 dimer for H3.3-specific recognition Simon J. Elsässer, Hongda Huang, Peter W. Lewis, Jason W. Chin, C. David Allis and Dinshaw J. Patel

The EMBO Journal 31: 4045-4056 (10-17-12)

The EMBO Journal 31: 4045-4056 The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo Niklas Feldhahn, Elisabetta Ferretti, Davide F Robbiani, Elsa Callen, Stephanie Deroubaix, Licia Selleri, Andre Nussenzweig and Michel C … More »