Growth signal can influence cancer cells’ vulnerability to drugs, study suggests

Growth signal can influence cancer cells’ vulnerability to drugs, study suggestsResearchers found that exposure to the signal TGF-β causes changes in mouse tumor stem cells that help them evade a widely used anti-cancer drug. This did not happen to cells that did not receive TGF-β. More »

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Research captures transient details of HIV genome packaging

Researchers have employed a recently developed technique to capture how a viral protein, Gag, selectively extracts and packages viral RNA into the viral particles that exported to new cells. More »

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Virus-cutting enzyme helps bacteria remember a threat

Virus-cutting enzyme helps bacteria remember a threatThe enzyme Cas9 is well known for its ability to make precise cuts in a genome. New research reveals a new role for Cas9 in its native bacteria: helping the microbial immune system acquire a memory of an invading virus. More »

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Key to blocking influenza virus may lie in a cell’s own machinery

Key to blocking influenza virus may lie in a cell’s own machineryResearchers have found that the immune system fights a flu infection by turning off cellular enzymes the virus needs to put the final touches on new viral particles. The unfinished particles cannot spread infection to new cells. More »

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Drug-resistant bacteria lurk in subway stations, high school students discover

Drug-resistant bacteria lurk in subway stations, high school students discoverAs part of an effort to identify DNA found throughout New York City, students in Rockefeller’s Science Outreach Program have been swabbing surfaces in the subway system. Their work has turned up bacteria resistant to two common antibiotics. More »

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Jeffrey Ravetch wins Wolf Prize in Medicine

Jeffrey Ravetch wins Wolf Prize in MedicineConsidered one of the most prestigious prizes in medicine, the Wolf Prize recognizes Ravetch’s work on the molecular basis of the immune response, including the Fc receptor system that mediates antibody function in disease and health. More »

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Latent HIV may lurk in ‘quiet’ immune cells, research suggests

Latent HIV may lurk in ‘quiet’ immune cells, research suggestsWhen researchers sequenced and compared sites where the virus had integrated into the genomes of infected CD4 T cells, they found evidence dormant but dangerous HIV was hiding out in cells that had never been copied – not the more abundant cloned cells. More »

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Research implicates metabolic process of the liver in the spread of colorectal cancer

Research implicates metabolic process of the liver in the spread of colorectal cancerBy identifying genes that become activated in cancer cells that successfully metastasize to the liver, researchers at Rockefeller have implicated metabolic processes within the liver as a possible means by which starving transient cancer cells can go on to form deadly new colonies. More »

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Study detailing axonal death pathway may provide drug targets for neurodegenerative diseases

Study detailing axonal death pathway may provide drug targets for neurodegenerative diseasesExperiments show that a protein already implicated in degeneration, called Sarm1, functions to trigger the MAP kinase pathway. Inactivation of this pathway at any of three levels could block the death of damaged axons.
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Cancer biologist and physician Sohail Tavazoie is promoted to associate professor

Cancer biologist and physician Sohail Tavazoie receives promotionTavazoie, who joined Rockefeller in 2009, works to understand how cancer cells become able to escape a tumor and invade other organs, a process known as metastasis. He searches for genes and molecular pathways cancer cells exploit in order to metastasize and, with that knowledge, hopes to develop future treatments to prevent or interfere with the process.
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Long-acting drug effectively prevents HIV-like infection in monkeys

Long-acting drug effectively prevents HIV-like infection in monkeysBecause cabotegravir would require only one injection every three months, researchers hope this new drug, which has begun clinical testing, could improve some patients’ ability to take HIV prevention medication properly. More »

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Physician scientist, interested in obesity-related disease, to join faculty

Physician scientist, interested in obesity-related disease, to join facultyPaul Cohen, a molecular biologist and cardiologist, is returning to Rockefeller where he did his graduate work. In his new lab, Cohen will study the molecular origins of obesity-related metabolic disease with the goal of developing treatments. More »

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Facial motion activates a dedicated network within the brain, research shows

Facial motion activates a dedicated network within the brain, research showsLike humans, rhesus macaque monkeys have a network of small tareas within their brains that respond to images of faces. New research shows these so-called face patches also respond selectively to changing expressions and other facial motion. More »

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Jeffrey M. Friedman and Leslie B. Vosshall named 2014 AAAS Fellows

Rockefeller University scientists Jeffrey M. Friedman and Leslie B. Vosshall have been awarded the distinction of AAAS Fellow. Election as a fellow is an honor bestowed upon AAAS members by their peers. More »

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New research suggests an existing drug, riluzole, may prevent foggy ‘old age’ brain

New research suggests an existing drug, riluzole, may prevent foggy ‘old age’ brainAfter experiments showed treatment prevented normal decline in aging rats’ spatial memory, researchers found changes known to improve connections, and as a result, communication, between certain neurons within the brain’s hippocampus. More »

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‘Radiogenetics’ seeks to remotely control cells and genes

 ‘Radiogenetics’ seeks to remotely control cells and genesA team is developing a system that would make it possible to remotely control biological targets in living animals — rapidly, without wires, implants or drugs. During a test, they used radio waves or a magnetic field to turn on insulin production in mice. More »

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Discovery links shift in metabolism to stem cell renewal

Discovery links shift in metabolism to stem cell renewalNew research links stem cell metabolism with those cells’ decision to pick a fate or renew themselves. In experiments, exposure to a key metabolite called alpha-ketoglutarate enhanced the renewal of mouse embryonic stem cells. More »

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Rockefeller University Hospital shares $2.8 million contract to study preventing drug-resistant infections in the community

Rockefeller University Hospital shares $2.8 million contract to study preventing drug-resistant infections in the communityThe Community Acquired MRSA Project (“CAMP2″) will enroll patients with skin infections, provide English- and Spanish-language health education materials about community-acquired drug-resistant staph infections, and incorporate a home visit program by community health workers to evaluate the effectiveness of household decontamination in preventing reinfection and transmission. More »

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Atomic-level view provides new insight into translation of touch into nerve signals

Atomic-Level View Provides New Insight into Translation of Touch into Nerve SignalsAn ion channel responsible for dampening potentially painful sensations uses a never-before-seen mechanism to shut itself off: A lipid from the nearby cellular membrane protrudes into the channel, blocking it. More »

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Marc Tessier-Lavigne receives lifetime achievement award from biotech executives

Marc Tessier-Lavigne receives lifetime achievement award from biotech executivesThe annual recipient of the NY/NJ CEO Lifetime Achievement Award is nominated and elected by peers from within the biotechnology industry and it recognizes the extraordinary contributions of the awardees toward advancing medical science and products that address unmet medical needs, as well as in helping to create an environment that fosters the growth of the industry in the New York metropolitan area.
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