A new strategy devised by researchers at Rockefeller University harnesses the power of broadly neutralizing antibodies, along with a combination of compounds that induce viral transcription, in order to attack latent reservoirs of HIV-infected cells in an approach termed ‘shock and kill.’ More »
Early in development, chemical signals tell cells whether to turn into muscle, bone, brain or other tissue. By tracking cells’ responses to signals, researchers found the speed at which the signal arrives has an unexpected influence on that decision. More »
Casanova is recognized for discovering “holes” in the immune systems of otherwise healthy children that make them susceptible to specific, sometimes life-threatening infectious diseases. More »
By profiling the small RNAs circulating in the blood of healthy people versus those with heart failure, a research team identified three so-called microRNAs with the potential for use as indicators of injury to heart muscle. More »
Speaking at a hearing on public versus private contributions to medical breakthroughs, Rockefeller’s president explained the ecosystem responsible for taking a biological insight on, for example, how tumors spread, and turning it into a treatment that improves or saves lives. He also offered suggestions for how the federal government could further encourage such breakthroughs.
This new tool promises to allow scientists to explore the as-yet-unknown details of how cells unzip the double-stranded DNA molecule and replicate it, a process crucial to life. More »
Joseph Gleeson, a neurogeneticist, has left the University of California, San Diego, to establish his lab at Rockefeller, where he will continue hunting down the single-gene mutations responsible for an array of neurodevelopmental disorders. More »
Researchers at Rockefeller University have determined that the Abdominal-B (Abd-B) gene, previously known as the gene that sculpts the posterior parts of the developing fly, is also important for a complex courtship behavior, at least in the case of female flies. More »
By confining colonies of human embryonic stem cells to tiny circular patterns on glass plates, researchers have for the first time coaxed them into organizing themselves just as they would under natural conditions. More »
The brains of Alzheimer’s mice treated with the compound RU-505 showed less inflammation and better blood flow than those of untreated mice. The treated mice also performed better on memory tests. More »
Pieces of DNA, including viruses, found outside a microbe’s chromosomes may play a role in disease, but are nearly impossible to identify and sequence using conventional techniques. Researchers at Rockefeller have developed a solution. More »
Casanova is honored for his work on host genes and their products in infectious diseases. His lab is interested in why some children develop severe infectious diseases after coming into contact with certain pathogens, while most other children do not. More »
Rockefeller University researchers announce that they have coaxed a slightly modified form of the HIV-1 virus to not only infect pigtailed macaques but to cause full blown AIDS in the primates, an accomplishment that could accelerate the search for new AIDS treatments or vaccines. More »
Jue Chen, currently a tenured professor of biology at Purdue University in Indiana and Howard Hughes Medical Institute investigator, studies transporter proteins that act as the cell’s pumping machinery, and their role in health and disease. More »
The Rockefeller University awarded doctoral degrees to 24 students at its convocation ceremony today. Additionally, the university awarded three honorary degrees, to John Gurdon, Julian Robertson and Sinya Yamanaka. Each doctoral candidate was presented for the degree by his or her mentor, a tradition dating back to the university’s first commencement ceremony in 1959.
Research shows that recovery from deep anesthesia is not a smooth, linear process but is instead a dynamic journey with specific states of activity the brain must temporarily occupy on the way to full recovery. More »
Schramek, one of just two individuals receiving the annual award, is being recognized for his proposal of a project that used sequence-based personalized medicine to treat the most devastating features of cancer. The award comes with a $50,000 prize and a $5,000 donation to support seminars at Rockefeller. More »
New structural images help explain how young neurons make the right connections, showing how a signal, Netrin-1, interacts with specific receptors that tell neurons in which direction to reach.
A new technique allows researchers to examine gene expression in neurons that send messages to a synapse. A test run examined dopamine neurons that project to the brain region known as the nucleus accumbens.