MacKinnon lab charts the anatomy of three molecular channels

MacKinnon lab charts the anatomy of three molecular channelsBy determining the three-dimensional structures of these molecules down to the level of atoms, the researchers have unlocked key details as to how they function in the body. More »

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Biophysicist Gregory M. Alushin receives White House honor for early career scientists

New research offers clues into how the brain shapes perception to control behaviorAlushin, who recently joined Rockefeller as assistant professor, has been chosen by President Obama as a recipient of the Presidential Early Career Award for Scientists and Engineers. The prestigious award, given annually by the White House, recognizes scientists and engineers who show exceptional potential early on in their careers. More »

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New research offers clues into how the brain shapes perception to control behavior

New research offers clues into how the brain shapes perception to control behaviorSome of the visual information our brains receive is potentially misleading. New research on fruit flies demonstrates how even a simple brain can filter out such misinformation, hinting at how our own brains might shape how we see the world—and how we react to it. More »

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Scientists learn how to ramp up microbes’ ability to make memories

Scientists learn how to ramp up microbes’ ability to make memoriesResearchers have identified a mutation that prompts bacterial cells to acquire genetic memories 100 times more frequently than they do naturally. This discovery provides a powerful research tool and could bring scientists one step closer to developing DNA-based data storage devices. More »

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Research on sweat glands suggests a route to better skin grafts

Research on sweat glands suggests a route to better skin graftsScientists have discovered the signaling pathways that help hair follicles and sweat glands form during development, and identified the mechanism that allows both of these features to coexist in human skin. The findings may improve the methods used to grow tissue used in grafting procedures.
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Researchers develop automated melanoma detector for skin cancer screening

Researchers develop automated melanoma detector for skin cancer screeningDoctors have trouble diagnosing melanoma because benign moles look very similar to malignant growths. But in developing a new technology that automatically extracts quantitative data from images of melanomas, scientists hope to help doctors detect the disease earlier and avoid unnecessary biopsies. More »

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Human embryo discovery wins People’s Choice of Science Breakthrough of the Year

Human embryo discovery wins People’s Choice Science Breakthrough of the YearA revolutionary system that allows researchers to study human embryo development in the lab was chosen by Science magazine readers as the scientific advancement of 2016 that has done the most to benefit humanity, answer long-standing questions, or pave the way for fruitful research.
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New molecular map reveals how cells spew out potassium

New molecular map reveals how cells spew out potassiumResearchers have determined for the first time the complete structure of an ion channel known as BK, or “big potassium.” This molecular map offers new insights on how BK works and may aid in the development of treatments for diseases in which it malfunctions. More »

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New structure shows how cells assemble protein-making machinery

New structure shows how cells assemble protein-making machineryResearchers have created the most detailed images to date of a particle destined to become part of a ribosome. Their findings gave them a new view of how these essential nano-machines are put together. More »

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Fifty years after landmark methadone discovery, stigmas and misunderstandings persist

Fifty years after landmark methadone discovery, stigmas and misunderstandings persistIn 1966, Rockefeller scientists published a landmark paper that would lead to the first medical treatment for heroin addiction. The drug has helped millions of heroin users around the world, yet its use in the United States remains controversial. More »

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First structural map of the cystic fibrosis protein sheds light on how mutations cause disease

First structural map of the cystic fibrosis protein sheds light on how mutations cause diseaseA map that shows the arrangement of atoms within the cystic fibrosis protein will help researchers better understand how specific mutations cause disease. Ultimately, this knowledge may reveal potential targets for new drugs. More »

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Elaine Fuchs to receive 2016 Vanderbilt Prize in Biomedical Science

Elaine Fuchs to receive 2016 Vanderbilt Prize in Biomedical ScienceThe prize, given by Vanderbilt University School of Medicine, recognizes women with outstanding research accomplishments who have also made significant contributions to mentoring other women in science. Fuchs is being honored for her innovative use of reverse genetics to understand skin diseases and cancer stem cells. More »

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Survey of New York City soil uncovers medicine-making microbes

Survey of New York City soil uncovers medicine-making microbesSifting soil from city parks, scientists have found microbial genes capable of making compounds whose potent effects can make them valuable tools in the fight against disease. Their research suggests that many more await discovery, even in a place as mundane as urban dirt. More »

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Rockefeller’s Science Outreach program explores the microbes in food

Rockefeller’s Science Outreach program explores the microbes in foodHigh school students designed research projects to investigate the role that microscopic organisms play in cheeses and other foods. The program aims to let students experience the scientific method firsthand. More »

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Jean-Laurent Casanova receives the 2016 Inserm Grand Prix

Jean-Laurent CasanovaGiven by Inserm, the French National Institute of Health and Medical Research, the Grand Prix honors researchers whose work has contributed to the institute’s scientific excellence. Casanova is being recognized for his work on the genetic basis of infectious diseases. More »

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New research clarifies why wounds heal more slowly with age

New research clarifies why wounds heal more slowly with age With age, it takes longer for skin cells to close an injury. New research shows that a breakdown in communication between these cells and neighboring immune cells causes this delay—a discovery that has implications for improving healing among older people. More »

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Gaby Maimon, who studies sophisticated brain functions in fruit flies, is promoted to associate professor

Gaby Maimon, who studies sophisticated brain functions in fruit flies, is promoted to associate professorAs head of the Laboratory of Integrative Brain Function, Maimon uses flies to study the computations with which the brain estimates values like angles and time. His promotion is effective January 1. More »

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Researchers discover new antibiotics by sifting through the human microbiome

MRSA screenThe bacteria we carry within us could be a untapped source of new drugs. Researchers put this idea to the test by mining the human microbiome for new antibiotics—and identified two compounds that might be effective against some particularly dangerous bacteria. More »

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Researchers shed new light on RNA’s journey out of a cell’s nucleus

Researchers shed new light on RNA’s journey out of a cell’s nucleusTo make proteins, cells must export RNA from their carefully guarded nuclei. Researchers have determined the structure of one important component of the restrictive gate through which this cargo must pass, with implications for understanding disease. More »

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Scientists prove how genetics change behavior by studying worms’ foraging strategies

Scientists prove how genetics change behavior by studying worms’ foraging strategiesLike all animals, C. elegans worms pay attention to their peers and can adjust their behavior in response to competition. Neuroscientists have discovered a genetic component of this social phenomenon, providing concrete biological evidence for game theory. More »

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