New structural studies reveal workings of a molecular pump that ejects cancer drugs

New structural studies reveal workings of a molecular pump that ejects cancer drugsSometimes cells spit out things we don’t want them to—like medications. Researchers have determined the three-dimensional structure of a tiny pump that expels, among other things, chemotherapy agents. This new knowledge could lead to the design of more effective drugs. More »

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New research explains why a common bacterium can produce severe illness

New research explains why a common Staphylococcus bacterium can produce severe illnessHow can the same infection result in dramatically different levels of illness in two different people? A new study identifies two conditions—a genetic immunodeficiency and delayed acquired immunity—that explain why a patient developed a life-threatening disease in response to a common strain of bacterium. More »

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Oceanographer and explorer Sylvia Earle will receive the 2017 Lewis Thomas Prize

Oceanographer and explorer Sylvia Earle will receive the 2017 Lewis Thomas PrizeOceanographer and explorer Sylvia Earle has been named the recipient of Rockefeller’s prestigious science writing prize. The award recognizes Earle’s body of work, which includes memoirs, atlases, and children’s books, as well as advocacy for global marine conservation. Earle will be honored at an award ceremony on March 6. More »

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Jeffrey V. Ravetch receives 2017 Ross Prize in Molecular Medicine

Jeffrey V. Ravetch receives 2017 Ross Prize in Molecular MedicineRavetch, who studies the role of antibodies in the immune system, has won the 2017 Ross Prize in Molecular Medicine. Given by The Feinstein Institute for Medical Research and its journal Molecular Medicine, the award recognizes scientists who have made a significant impact on the understanding of human disease pathogenesis. More »

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Crowdsourcing effort helps researchers predict how a molecule will smell

Crowdsourcing effort helps researchers predict how a molecule will smellWhile it’s possible to anticipate the color of light or the pitch of sound, odor defies prediction. New research has taken an important step toward decoding smell, by linking a scent back to a molecule’s chemistry.
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Mouse studies offer new insights about cocaine’s effect on the brain

Newly discovered beetle species named after Rockefeller’s Daniel KronauerResearchers have determined how a specific protein regulates the brain’s response to cocaine. Their findings provide fresh insights into the neurobiology of addiction, and could lead to the development of better interventions and treatments.
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Newly discovered beetle species named after Rockefeller’s Daniel Kronauer

Newly discovered beetle species named after Rockefeller’s Daniel KronauerA former Rockefeller postdoctoral associate has named a new species of beetle Nymphister kronaueri, after his mentor, Daniel Kronauer. Discovered in the Costa Rican rainforest, the beetle anchors itself tightly to backside of nomadic ants, hitchhiking a ride to new nesting sites. More »

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Scientists discover an unexpected influence on dividing stem cells’ fate

Scientists reveal an unexpected influence on dividing stem cells' fateWhen it divides, a stem cell has a choice: produce more stem cells or turn into the specific types of cells that compose skin, muscle, brain, or other tissue. New experiments in skin show this decision can be altered if tiny organs within cells aren’t positioned and divvied up properly. More »

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Howard C. Hang receives 2017 Eli Lilly Award in Biological Chemistry

Hang is recognized for outstanding research on the mechanisms of microbe–host interactions
Hang, who develops chemical tools to study microbe–host interactions, has won the 2017 Eli Lilly Award in Biological Chemistry. The prize, given by the American Chemical Society, recognizes outstanding research in biological chemistry of unusual merit and independence of thought and originality. More »

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Encouraging clinical results for an antibody drug to prevent or treat HIV

Encouraging results for an antibody drug to prevent or treat HIVA drug known as 10-1074, based on a human antibody against HIV, has dramatically reduced virus levels in patients and appeared to prevent infection among those at high risk, according to data from a new clinical trial. More »

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Atomic-scale view of bacterial proteins offers path to new tuberculosis drugs

New molecular insights are giving scientists ideas for how to combat antibiotic-resistant strains
In studying a cousin of the bacterium that causes tuberculosis, scientists have drawn a molecular map of the target for rifampicin, a common antibiotic. They are now using it in an effort to combat multi-resistant tuberculosis, for which existing treatments don’t work. More »

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Study reveals the structure of a protein crucial for DNA replication

Study reveals the structure of a protein crucial for DNA replicationFor life to propagate, the instructions in our DNA must be copied and passed on to future generations. Focusing on the structure of the machinery that executes this process, scientists have revealed that the orientation of the proteins involved is different from what has previously been reported. More »

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Discovery helps explain why only some people develop life-threatening dengue infections

Discovery helps explain why only some people develop life-threatening dengue infectionsAfter contracting dengue fever once, certain people who encounter the virus again develop much more severe infections. New research identifies an immunological signature that could help identify and better treat these patients. More »

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Rockefeller president Richard P. Lifton releases statement on U.S. immigration policy

In response to an executive order on immigration issued by President Donald J. Trump Friday, Rockefeller University President Richard P. Lifton today released a statement condemning the policy and outlining the detrimental effects it will have on the development of science and technology in the U.S. More »

Researchers explore how protein production gets distorted in skin cancer

Researchers explore how protein production gets distorted in skin cancerResearchers have shown that a shift in translation, the process by which cells produce proteins from RNA, may promote skin cancer. The discovery could potentially aid the development of new treatments.
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Antibody Combination Puts HIV on the Ropes

Antibody combination puts HIV on the ropesResearchers have shown that a combination of three antibody drugs can completely suppress HIV in infected mice. The antibodies were isolated from a patient whose immune system mounted an unusually effective response against the virus. More »

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Elaine Fuchs wins 2017 McEwen Award for Innovation

Elaine Fuchs wins 2017 McEwen Award for InnovationFuchs has received the 2017 McEwen Award for Innovation. The prize, given by the International Society for Stem Cell Research, recognizes outstanding contributions in the fields of stem cell research or regenerative medicine. Fuchs will receive a $100,000 award and present her research at the society’s annual meeting in June. More »

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MacKinnon lab charts the anatomy of three molecular channels

MacKinnon lab charts the anatomy of three molecular channelsBy determining the three-dimensional structures of these molecules down to the level of atoms, the researchers have unlocked key details as to how they function in the body. More »

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Biophysicist Gregory M. Alushin receives White House honor for early career scientists

New research offers clues into how the brain shapes perception to control behaviorAlushin, who recently joined Rockefeller as assistant professor, has been chosen by President Obama as a recipient of the Presidential Early Career Award for Scientists and Engineers. The prestigious award, given annually by the White House, recognizes scientists and engineers who show exceptional potential early on in their careers. More »

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New research offers clues into how the brain shapes perception to control behavior

New research offers clues into how the brain shapes perception to control behaviorSome of the visual information our brains receive is potentially misleading. New research on fruit flies demonstrates how even a simple brain can filter out such misinformation, hinting at how our own brains might shape how we see the world—and how we react to it. More »

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