One signal means different things to stem cells versus their progeny

One signal means different things to stem cells versus their progenyWhen researchers shut down hair follicle stem cells’ ability to respond to a protein, the cells began dividing prematurely forming a pocket of new cells (red). The same protein has a different effect on the stem cells’ progeny. More »

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Single gene links susceptibility to rare infections with predisposition to autoimmune disease

Single gene links susceptibility to rare infections with predisposition to autoimmune diseaseWhen scientists scanned the brains of patients who lack a particular immune protein, they saw calcium deposits (center white spots) linked with certain diseases that occur as a result of harmful and unnecessary inflammation. More »

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Atomic map reveals clues to how cholesterol is made

Atomic map reveals clues to how cholesterol is madeAn enzyme embedded in the cell membrane performs a crucial step in the complex process by which cells produce cholesterol. Researchers have examined the enzyme’s structure to better understand how it works. More »

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Newly discovered brain cells explain a prosocial effect of oxytocin

Newly discovered brain cells explain a prosocial effect of oxytocinWhen activated by the ‘love hormone’ oxytocin, a class of star-shaped neurons (left) in the brain’s cortex encourages female mice to take an interest in males, but only when the females are in heat. More »

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Rockefeller neurobiology lab is awarded first-round BRAIN initiative grant

Rockefeller neurobiology lab is awarded first-round BRAIN initiative grantResearchers are developing a technology to remotely turn neurons and other cells on or off. The bright spots represent cells undergoing a change that would enable neurons to fire on command. More »

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‘Programmable’ antibiotic harnesses an enzyme to attack drug-resistant microbes

“Programmable” antibiotic harnesses an enzyme to attack drug-resistant microbesBy co-opting a system bacteria normally use to defend themselves, researchers targeted and killed off colonies of the antibiotic resistant Staph cells on mouse skin. The treatment left behind the drug-susceptible microbes. More »

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Rockefeller postdoc Stephen Brohawn named Blavatnik Award regional finalist

Rockefeller postdoc Stephen Brohawn named Blavatnik Award regional finalistBrohawn, a member of Roderick MacKinnon’s Laboratory of Molecular Neurobiology and Biophysics, studies how proteins called mechanosensitive ion channels sense mechanical forces. He is one of nine finalists from the New York region. More »

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Stanford’s Lucy Shapiro to receive 2014 Pearl Meister Greengard Prize

Stanford's Lucy Shapiro to receive 2014 Pearl Meister Greengard Prize The Rockefeller University has announced that Lucy Shapiro, professor of developmental biology at Stanford University School of Medicine, will receive the 2014 Pearl Meister Greengard Prize. The annual award, which celebrates the achievements of outstanding women in science, will be presented to Shapiro on the Rockefeller campus November 11. More »

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New technique reveals a role for histones in cell division

New technique reveals a role for histones in cell divisionResearchers have found that key aspects of cell division, such as the formation of the support structure (green) for the envelope that surrounds the nucleus, depend on the presence of DNA-organizing proteins known as histones. More »

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Imaging studies open a window on how effective antibodies are formed

Imaging studies open a window on how effective antibodies are formedBy imaging the immune response, researchers have observed how two types of immune cells interact with one another during a critical period following infection in order to prepare the best antibodies and establish long-lasting protection. More »

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Hironori Funabiki promoted to professor

Funabiki’s research has pointed to a role for DNA-packaging proteins known as histones in the formation of structures involved in cell division, with implications for understanding and treating disease. More »

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Research hints at why stress is more devastating for some

Research hints at why stress is more devastating for someSome bounce back from stress, while others struggle with it, even developing anxiety and depression as a result. In experiments with mice, researchers have revealed the molecular origins of this so-called stress gap.
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Discovery reveals how bacteria distinguish harmful versus helpful viruses

Discovery reveals how bacteria distinguish harmful versus helpful virusesViruses can kill bacteria, or viruses can help the microbes by lending them potentially useful genes. New research shows Staph bacteria have an immune system capable of distinguishing dangerous invaders from potentially beneficial ones. More »

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Research explains how cellular guardians of the gut develop

Research explains how cellular guardians of the intestine developA specialized class of immune cell inhabits the thin layer of tissue that lines the intestine. New experiments reveal how these cells arise, sometimes from other mature immune cells. More »

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Antibodies, together with viral ‘inducers,’ found to control HIV in mice

Antibodies, together with viral ‘inducers,’ found to control HIV in miceA new strategy devised by researchers at Rockefeller University harnesses the power of broadly neutralizing antibodies, along with a combination of compounds that induce viral transcription, in order to attack latent reservoirs of HIV-infected cells in an approach termed ‘shock and kill.’ More »

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An embryonic cell’s fate is sealed by the speed of a signal

An embryonic cell’s fate is sealed by the speed of a signalEarly in development, chemical signals tell cells whether to turn into muscle, bone, brain or other tissue. By tracking cells’ responses to signals, researchers found the speed at which the signal arrives has an unexpected influence on that decision. More »

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Jean-Laurent Casanova honored with 2014 Sanofi-Institut Pasteur Award

Jean-Laurent Casanova honored with 2014 Sanofi-Institut Pasteur AwardCasanova is recognized for discovering “holes” in the immune systems of otherwise healthy children that make them susceptible to specific, sometimes life-threatening infectious diseases. More »

Small RNAs in blood may reveal heart injury

SmallBy profiling the small RNAs circulating in the blood of healthy people versus those with heart failure, a research team identified three so-called microRNAs with the potential for use as indicators of injury to heart muscle. More »

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Medical innovation requires federal support and structural improvements, Marc Tessier-Lavigne tells members of Congress

Medical innovation requires federal support and structural improvements, Marc Tessier-Lavigne tells members of CongressSpeaking at a hearing on public versus private contributions to medical breakthroughs, Rockefeller’s president explained the ecosystem responsible for taking a biological insight on, for example, how tumors spread, and turning it into a treatment that improves or saves lives. He also offered suggestions for how the federal government could further encourage such breakthroughs.
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Discovery of pro-metastasis protein reveals mysterious link to neurodegeneration

Discovery of pro-metastasis protein reveals mysterious link to neurodegenerationMice injected with metastatic breast cancer cells showed less metastasis when researchers silenced the protein TARBP2 in these cells. TARBP2 appears to promote metastasis in part by blocking suppressor genes, including two linked with neurodegeneration. More »

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