Small RNAs in blood may reveal heart injury

SmallBy profiling the small RNAs circulating in the blood of healthy people versus those with heart failure, a research team identified three so-called microRNAs with the potential for use as indicators of injury to heart muscle. More »

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Medical innovation requires federal support and structural improvements, Marc Tessier-Lavigne tells members of Congress

Medical innovation requires federal support and structural improvements, Marc Tessier-Lavigne tells members of CongressSpeaking at a hearing on public versus private contributions to medical breakthroughs, Rockefeller’s president explained the ecosystem responsible for taking a biological insight on, for example, how tumors spread, and turning it into a treatment that improves or saves lives. He also offered suggestions for how the federal government could further encourage such breakthroughs.
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Discovery of pro-metastasis protein reveals mysterious link to neurodegeneration

Discovery of pro-metastasis protein reveals mysterious link to neurodegenerationMice injected with metastatic breast cancer cells showed less metastasis when researchers silenced the protein TARBP2 in these cells. TARBP2 appears to promote metastasis in part by blocking suppressor genes, including two linked with neurodegeneration. More »

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Researchers create the first model of the DNA ‘replication fork’

Researchers create the first model of the DNA ‘replication fork’This new tool promises to allow scientists to explore the as-yet-unknown details of how cells unzip the double-stranded DNA molecule and replicate it, a process crucial to life. More »

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New faculty member uses genetic sequencing to investigate childhood brain disease

New faculty member uses genetic sequencing to investigate childhood brain diseaseJoseph Gleeson, a neurogeneticist, has left the University of California, San Diego, to establish his lab at Rockefeller, where he will continue hunting down the single-gene mutations responsible for an array of neurodevelopmental disorders. More »

Genetically driven gut feelings help female flies choose a mate

Genetically driven gut feelings help female flies choose a mateResearchers at Rockefeller University have determined that the Abdominal-B (Abd-B) gene, previously known as the gene that sculpts the posterior parts of the developing fly, is also important for a complex courtship behavior, at least in the case of female flies. More »

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Using geometry, researchers coax human embryonic stem cells to organize themselves

Using geometry, researchers coax human embryonic stem cells to organize themselvesBy confining colonies of human embryonic stem cells to tiny circular patterns on glass plates, researchers have for the first time coaxed them into organizing themselves just as they would under natural conditions. More »

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Potential Alzheimer’s drug prevents abnormal blood clots in the brain

Potential Alzheimer’s drug prevents abnormal blood clots in the brainThe brains of Alzheimer’s mice treated with the compound RU-505 showed less inflammation and better blood flow than those of untreated mice. The treated mice also performed better on memory tests. More »

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Sequencing efforts miss DNA crucial to bacteria’s disease causing power

Sequencing efforts miss DNA crucial to bacteria’s disease causing powerPieces of DNA, including viruses, found outside a microbe’s chromosomes may play a role in disease, but are nearly impossible to identify and sequence using conventional techniques. Researchers at Rockefeller have developed a solution. More »

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Jean-Laurent Casanova to receive 2014 Robert Koch Award

New monkey model for AIDS offers promise for medical researchCasanova is honored for his work on host genes and their products in infectious diseases. His lab is interested in why some children develop severe infectious diseases after coming into contact with certain pathogens, while most other children do not. More »

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New monkey model for AIDS offers promise for medical research

New monkey model for AIDS offers promise for medical researchRockefeller University researchers announce that they have coaxed a slightly modified form of the HIV-1 virus to not only infect pigtailed macaques but to cause full blown AIDS in the primates, an accomplishment that could accelerate the search for new AIDS treatments or vaccines. More »

Structural biologist, focused on cell transport machinery, to join faculty

Structural biologist, focused on cell transport machinery, to join facultyJue Chen, currently a tenured professor of biology at Purdue University in Indiana and Howard Hughes Medical Institute investigator, studies transporter proteins that act as the cell’s pumping machinery, and their role in health and disease. More »

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Twenty-four students receive Ph.D.s at Rockefeller’s 56th Convocation

The Rockefeller University awarded doctoral degrees to 24 students at its convocation ceremony today. Additionally, the university awarded three honorary degrees, to John Gurdon, Julian Robertson and Sinya Yamanaka. Each doctoral candidate was presented for the degree by his or her mentor, a tradition dating back to the university’s first commencement ceremony in 1959.
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To recover consciousness, brain activity passes through newly detected states

To recover consciousness, brain activity passes through newly detected statesResearch shows that recovery from deep anesthesia is not a smooth, linear process but is instead a dynamic journey with specific states of activity the brain must temporarily occupy on the way to full recovery. More »

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Daniel Schramek awarded Regeneron Prize for Creative Innovation by a Postdoctoral Fellow

Schramek, one of just two individuals receiving the annual award, is being recognized for his proposal of a project that used sequence-based personalized medicine to treat the most devastating features of cancer. The award comes with a $50,000 prize and a $5,000 donation to support seminars at Rockefeller. More »

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Research details how developing neurons sense a chemical cue

Netrin-1_Xu_thumb_05302014New structural images help explain how young neurons make the right connections, showing how a signal, Netrin-1, interacts with specific receptors that tell neurons in which direction to reach.
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Researchers profile active genes in neurons based on connections

140519_friedman_retrotrap1_thumbA new technique allows researchers to examine gene expression in neurons that send messages to a synapse. A test run examined dopamine neurons that project to the brain region known as the nucleus accumbens.
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Searching for drugs in dirt, researchers call on citizen scientists

dirtonscale_thumb_2014 Soil microbes are believed to make a wealth of as-yet undiscovered molecules, including antibiotics. But getting at them isn’t easy. To make these potentially helpful bugs easier to find, researchers want to create maps, and they need help.
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Rockefeller ranks first in scientific impact among list of global institutions

The Rockefeller University has the highest percentage of frequently cited scientific publications of 750 top universities worldwide, according to ranking created by the Center for Science and Technology Studies of Leiden University in The Netherlands. More »

NY City Council approves new Rockefeller laboratory building

The building, first envisioned over two years ago and known as the River Building, will house bioscience laboratories, and will serve as a replacement for existing lab facilities that are reaching the end of their operational life and are no longer suitable for modern science. More »