In order to better understand how genetic mutations give rise to cystic fibrosis, researchers need to map the protein responsible for the disorder. The new structure has led to new insights on how this molecular channel functions. More »
In some people whose cognitive functions are weakened due to Alzheimer’s, the disease can be traced back to changes in the brain’s blood vasculature. Scientists have found that a protein involved in blood clotting and inflammation might offer a potential path to new drugs. More »
“David’s integrity, strength, wisdom, and judgment—and especially his unequivocal commitment to excellence—shaped the University and made it the powerhouse of biomedical discovery it is today,” said Russell L. Carson, chair of the Board, and Richard P. Lifton, president, in a statement. More »
Two new technologies are helping scientists understand new aspects of organ and nervous system development in C. elegans. One allows them to image worms developing in a natural environment, while the other makes it possible to track single neurons as the worms grow. More »
Researchers have found that a new approach to HIV treatment can suppress an HIV-like virus for an extended period in monkeys. The therapy employs antibodies and takes advantage of the immune system’s natural defenses. More »
Could a genetic predisposition to autism together with early stress have a more detrimental effect on boys than on girls? In experiments with mice, researchers found evidence that three factors—genes, environment, and sex—work together to produce problems with social interaction, a hallmark of autism. More »
Scientists have discovered a potential new target for the treatment of leukemia that potentially could augment the activity of BET inhibitors, drugs currently in clinical trials. These therapies act on histones, DNA’s packaging proteins, to reset gene regulatory programs that go awry in cancer.
Tags: C. David Allis, cancer, chemical and structural biology, ENL, epigenetics, epigenome, genetics and genomics, histones, Leukemia, Liling Wan, molecular and cell biology
Cohn, a member of Vanessa Ruta’s Laboratory of Neurophysiology and Behavior, is one of 13 recipients of this prestigious prize, which is given to graduate students at or near the completion of their studies in the biological sciences. Winners are selected for the originality and significance of their thesis research. More »
Sometimes cells spit out things we don’t want them to—like medications. Researchers have determined the three-dimensional structure of a tiny pump that expels, among other things, chemotherapy agents. This new knowledge could lead to the design of more effective drugs. More »
How can the same infection result in dramatically different levels of illness in two different people? A new study identifies two conditions—a genetic immunodeficiency and delayed acquired immunity—that explain why a patient developed a life-threatening disease in response to a common strain of bacterium. More »
Oceanographer and explorer Sylvia Earle has been named the recipient of Rockefeller’s prestigious science writing prize. The award recognizes Earle’s body of work, which includes memoirs, atlases, and children’s books, as well as advocacy for global marine conservation. Earle will be honored at an award ceremony on March 6. More »
Ravetch, who studies the role of antibodies in the immune system, has won the 2017 Ross Prize in Molecular Medicine. Given by The Feinstein Institute for Medical Research and its journal Molecular Medicine, the award recognizes scientists who have made a significant impact on the understanding of human disease pathogenesis. More »
While it’s possible to anticipate the color of light or the pitch of sound, odor defies prediction. New research has taken an important step toward decoding smell, by linking a scent back to a molecule’s chemistry.
Researchers have determined how a specific protein regulates the brain’s response to cocaine. Their findings provide fresh insights into the neurobiology of addiction, and could lead to the development of better interventions and treatments.
A former Rockefeller postdoctoral associate has named a new species of beetle Nymphister kronaueri, after his mentor, Daniel Kronauer. Discovered in the Costa Rican rainforest, the beetle anchors itself tightly to backside of nomadic ants, hitchhiking a ride to new nesting sites. More »
When it divides, a stem cell has a choice: produce more stem cells or turn into the specific types of cells that compose skin, muscle, brain, or other tissue. New experiments in skin show this decision can be altered if tiny organs within cells aren’t positioned and divvied up properly. More »
Hang, who develops chemical tools to study microbe–host interactions, has won the 2017 Eli Lilly Award in Biological Chemistry. The prize, given by the American Chemical Society, recognizes outstanding research in biological chemistry of unusual merit and independence of thought and originality. More »
A drug known as 10-1074, based on a human antibody against HIV, has dramatically reduced virus levels in patients and appeared to prevent infection among those at high risk, according to data from a new clinical trial. More »
In studying a cousin of the bacterium that causes tuberculosis, scientists have drawn a molecular map of the target for rifampicin, a common antibiotic. They are now using it in an effort to combat multi-resistant tuberculosis, for which existing treatments don’t work. More »
For life to propagate, the instructions in our DNA must be copied and passed on to future generations. Focusing on the structure of the machinery that executes this process, scientists have revealed that the orientation of the proteins involved is different from what has previously been reported. More »