Study detailing axonal death pathway may provide drug targets for neurodegenerative diseases

Study detailing axonal death pathway may provide drug targets for neurodegenerative diseasesExperiments show that a protein already implicated in degeneration, called Sarm1, functions to trigger the MAP kinase pathway. Inactivation of this pathway at any of three levels could block the death of damaged axons.
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Cancer biologist and physician Sohail Tavazoie is promoted to associate professor

Cancer biologist and physician Sohail Tavazoie receives promotionTavazoie, who joined Rockefeller in 2009, works to understand how cancer cells become able to escape a tumor and invade other organs, a process known as metastasis. He searches for genes and molecular pathways cancer cells exploit in order to metastasize and, with that knowledge, hopes to develop future treatments to prevent or interfere with the process.
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Long-acting drug effectively prevents HIV-like infection in monkeys

Long-acting drug effectively prevents HIV-like infection in monkeysBecause cabotegravir would require only one injection every three months, researchers hope this new drug, which has begun clinical testing, could improve some patients’ ability to take HIV prevention medication properly. More »

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Physician scientist, interested in obesity-related disease, to join faculty

Physician scientist, interested in obesity-related disease, to join facultyPaul Cohen, a molecular biologist and cardiologist, is returning to Rockefeller where he did his graduate work. In his new lab, Cohen will study the molecular origins of obesity-related metabolic disease with the goal of developing treatments. More »

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Facial motion activates a dedicated network within the brain, research shows

Facial motion activates a dedicated network within the brain, research showsLike humans, rhesus macaque monkeys have a network of small tareas within their brains that respond to images of faces. New research shows these so-called face patches also respond selectively to changing expressions and other facial motion. More »

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Jeffrey M. Friedman and Leslie B. Vosshall named 2014 AAAS Fellows

Rockefeller University scientists Jeffrey M. Friedman and Leslie B. Vosshall have been awarded the distinction of AAAS Fellow. Election as a fellow is an honor bestowed upon AAAS members by their peers. More »

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New research suggests an existing drug, riluzole, may prevent foggy ‘old age’ brain

New research suggests an existing drug, riluzole, may prevent foggy ‘old age’ brainAfter experiments showed treatment prevented normal decline in aging rats’ spatial memory, researchers found changes known to improve connections, and as a result, communication, between certain neurons within the brain’s hippocampus. More »

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‘Radiogenetics’ seeks to remotely control cells and genes

 ‘Radiogenetics’ seeks to remotely control cells and genesA team is developing a system that would make it possible to remotely control biological targets in living animals — rapidly, without wires, implants or drugs. During a test, they used radio waves or a magnetic field to turn on insulin production in mice. More »

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Discovery links shift in metabolism to stem cell renewal

Discovery links shift in metabolism to stem cell renewalNew research links stem cell metabolism with those cells’ decision to pick a fate or renew themselves. In experiments, exposure to a key metabolite called alpha-ketoglutarate enhanced the renewal of mouse embryonic stem cells. More »

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Rockefeller University Hospital shares $2.8 million contract to study preventing drug-resistant infections in the community

Rockefeller University Hospital shares $2.8 million contract to study preventing drug-resistant infections in the communityThe Community Acquired MRSA Project (“CAMP2″) will enroll patients with skin infections, provide English- and Spanish-language health education materials about community-acquired drug-resistant staph infections, and incorporate a home visit program by community health workers to evaluate the effectiveness of household decontamination in preventing reinfection and transmission. More »

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Atomic-level view provides new insight into translation of touch into nerve signals

Atomic-Level View Provides New Insight into Translation of Touch into Nerve SignalsAn ion channel responsible for dampening potentially painful sensations uses a never-before-seen mechanism to shut itself off: A lipid from the nearby cellular membrane protrudes into the channel, blocking it. More »

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Marc Tessier-Lavigne receives lifetime achievement award from biotech executives

Marc Tessier-Lavigne receives lifetime achievement award from biotech executivesThe annual recipient of the NY/NJ CEO Lifetime Achievement Award is nominated and elected by peers from within the biotechnology industry and it recognizes the extraordinary contributions of the awardees toward advancing medical science and products that address unmet medical needs, as well as in helping to create an environment that fosters the growth of the industry in the New York metropolitan area.
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$150 million from the Stavros Niarchos Foundation and David Rockefeller launches major campus extension

$150 million from the Stavros Niarchos Foundation and David Rockefeller launch major campus extensionMarc Tessier-Lavigne, president of The Rockefeller University, today announced two leadership pledges of $75 million each from the Stavros Niarchos Foundation and David Rockefeller to launch a major extension of the University’s campus on the East River. Designed by Raphael Viñoly Architects, the project will add two acres to the existing 14 acres of the campus by building over the FDR East River Drive, enabling the creation of several new buildings with state-of-the-art laboratories, administrative space, a conference facility, a dining commons, and an outdoor amphitheater. More »

Research suggests how mosquitoes evolved an attraction to human scent

Research suggests how mosquitoes evolved an attraction to human scentTo understand the evolutionary basis of the mosquito’s attraction to humans, scientists examined the genes that drive preferences of two different subspecies. Their findings suggest that Aedes aegypti aegypti acquired a love for human body odor, a key step in specializing on people. More »

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C. David Allis wins the 2015 Breakthrough Prize in Life Sciences

C. David Allis wins the 2015 Breakthrough Prize in Life Sciences’Allis is recognized for his foundational research on the unexpected regulation of gene activation by modifications to proteins that package DNA, work with implications for many diseases including cancer. The Breakthrough Prize is worth $3 million, making it the richest prize in the life sciences, roughly double the Nobel Prize. More »

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3D deep-imaging advance likely to drive new biological insights

3D deep-imaging advance likely to drive new biological insights’In a significant technical advance, a team of neuroscientists at The Rockefeller University has devised a fast, inexpensive imaging method for probing the molecular intricacies of large biological samples in three dimensions, an achievement that could have far reaching implications in a wide array of basic biological investigations. More »

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Research resolves contradiction over protein’s role at telomeres

Research resolves contradiction over protein’s role at telomeres To determine the role of a protein found in the protective caps on human chromosomes, researchers engineered the telomeres to lack this protein. Previous studies suggested the altered telomeres would attach to one another, but they did not. More »

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Cori Bargmann awarded 2015 Benjamin Franklin Medal

New technique efficiently turns antibodies into highly tuned ‘nanobodies’Rockefeller University neurobiologist Cori Bargmann will receive the 2015 Benjamin Franklin Medal in Life Sciences for contributions that have led to major discoveries elucidating the relationship between genes, neurons, neural circuits and behavior. The award, announced this week, will be presented in April at The Franklin Institute in Philadelphia. More »

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New technique efficiently turns antibodies into highly tuned ‘nanobodies’

New technique efficiently turns antibodies into highly tuned ‘nanobodies’Antibodies’ tiny cousins have many potential uses, but scientists haven’t been able to take advantage of them. However, a new technique may make nanobodies dramatically more accessible for all kinds of research. More »

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One signal means different things to stem cells versus their progeny

One signal means different things to stem cells versus their progenyWhen researchers shut down hair follicle stem cells’ ability to respond to a protein, the cells began dividing prematurely. Meanwhile, when the same was done to their progeny cells, the fate of these cells shifted. More »

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