Search Results for: C. David Allis
Scientists in David Allis’s laboratory have shown how a mutated histone protein inhibits an enzyme, which normally keeps cell growth in check, and causes a rare form of pediatric brain cancer called DIPG. Their findings reveal a mechanism for inhibiting enzymes and could lead to the development of pharmaceuticals that mimic the action of these mutant proteins.
Molecular Cell 49:1121-1133 The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation Jaehoon Kim, Jung-Ae Kim, Robert K. McGinty, Uyen T.T. Nguyen, Tom W. Muir, C. David Allis and Robert G. Roeder
Science online: March 28, 2013 Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma Peter W. Lewis, Manuel M. Müller, Matthew S. Koletsky, Francisco Cordero, Shu Lin, Laura A. Banaszynski, Benjamin A. Garcia, Tom W. Muir, … More »
Allis leads one of five cancer research teams that are winners of $5 million in grant awards from The Starr Foundation’s Sixth Starr Cancer Consortium Grant Competition.
The researchers are being honored for their discovery of the molecular mechanisms governing circadian rhythm. This is the fourth major award Young and his colleagues have received in the past two years, including the Massry Prize, the Canada Gairdner International Award and the Louisa Gross Horwitz Prize from Columbia University. More »
Epigenetics: How Our Experiences Affect Our Offspring “We were all brought up to think the genome was it,” said Rockefeller University molecular biologist C. David Allis. “It’s really been a watershed in understanding that there is something beyond the … More »
Molecular Cell online: December 22, 2012 An H3K36 methylation-engaging tudor motif of polycomb-like proteins mediates PRC2 complex targeting Ling Cai, Scott B. Rothbart, Rui Lu, Bowen Xu, Wei-Yi Chen, Ashutosh Tripathy, Shira Rockowitz, Deyou Zheng, Dinshaw J. Patel, C. David … More »
Nature online: October 17, 2012 DAXX envelops an H3.3-H4 dimer for H3.3-specific recognition Simon J. Elsässer, Hongda Huang, Peter W. Lewis, Jason W. Chin, C. David Allis and Dinshaw J. Patel
The prize recognizes outstanding contributions to the biomedical sciences and the advancement of health, and Young is being honored for his groundbreaking work on the molecular biology of circadian rhythms. Young’s work spans nearly three decades of research on the biological clocks that regulate our bodies’ patterns of sleep and wakefulness, metabolism and response to disease. More »
Nature Structural & Molecular Biology online: July 15, 2012 Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events Stamatios Liokatis, Alexandra Stützer, Simon J Elsässer, Francois-Xavier Theillet, Rebecca Klingberg, Barth van Rossum, Dirk Schwarzer, C. David … More »
Researchers have discovered a novel mechanism by which influenza viruses hijack key regulators of the human body’s normal antiviral response in order to slip by it undetected. The results have major implications for our understanding of the biology of the seasonal influenza virus and suggest a possible target for a new class of antiviral and anti-inflammatory drugs. More »
Proceedings of the National Academy of Sciences USA 109: 5779-5784 Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast Jung-Ae Kima, Jer-Yuan Hsub, M. Mitchell Smithb and C. David Allis
Scheid is one of 13 awardees, all advanced graduate students at or near the completion of their studies in the biological sciences and chosen for the quality, originality and significance of their thesis research.
Since the introduction of Gleevec as a treatment for gastrointestinal stromal tumors, survival rates have climbed dramatically and recurrence has fallen by two-thirds. But over time, many patients develop resistance to the drug. Now, scientists at Rockefeller University and Memorial Sloan-Kettering Cancer Center have identified a molecule that acts as a survival factor for gastrointestinal tumors, a finding that may lead to next-generation therapies that can pick up where Gleevec leaves off. More »
The division of one cell into two is one of the most basic processes of life. One of the many tricks involved is the segregation of copied chromosomes to opposite ends of the cell before it divides. New research details for the first time the role of an epigenetic modification to the proteins that package DNA in the fundamental biological phenomenon, known as mitosis. More »
The path to fully developed cells from embryonic stem cells requires that the right genes are turned on and off at the right times. New research from Rockefeller University shows that tiny variations between gene-regulating histone proteins play an important role in determining how and when genes are read. The finding shows that each region of the genome may be even more specialized than previously expected and may open a new avenue of investigation regarding the mysterious causes of the human genetic disease known as ATR-X syndrome. More »
New findings, published in recent issues of Neuron and Science, indicate that malfunction of a protein complex that normally suppresses gene activation causes mental retardation in mice and humans and may even play a role in promoting susceptibility to drug addiction. More »
The development of blood from stem cell to fully formed blood cell follows a genetically determined program. When it doesn’t work properly, genetic mutations can cause the developing cells to turn cancerous. In research published in the journal Nature, Rockefeller University scientists show for the first time that a misreading of blood cells’ histone code is responsible for acute myeloid leukemia, a rare form of the deadly blood cancer. More »
Nadya Dimitrova, a graduate fellow in Titia de Lange’s Laboratory of Cell Biology and Genetics at Rockefeller University, has been named one of 13 winners of this year’s Harold M. Weintraub Graduate Student Award, administered by the Fred Hutchinson Cancer Research Center. More »
Some genes are regulated through a process by which proteins in the cell nucleus, called histones, are chemically modified by small “chemical marks.” New research from Rockefeller University scientists shows that during specific stages of differentiation in mouse embryonic stem cells, crucial marks can be removed by cutting off the end of the histone’s tail. More »