Search Results for: C. David Allis

C. David Allis wins the 2015 Breakthrough Prize in Life Sciences

C. David Allis wins the 2015 Breakthrough Prize in Life Sciences’Allis is recognized for his foundational research on the unexpected regulation of gene activation by modifications to proteins that package DNA, work with implications for many diseases including cancer. The Breakthrough Prize is worth $3 million, making it the richest prize in the life sciences, roughly double the Nobel Prize. More »

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David Allis, pioneer in epigenetics, to receive prestigious Japan Prize

Allis’s discovery that chemical “tags” bind to specific sections of histone proteins in order to activate or silence nearby genes has ignited the field of epigenetics, a relatively new area of study which explores the inheritance of physical changes that cannot be traced back to mutations in the DNA sequence. The Japan Prize, worth approximately half a million dollars, is among the most prestigious prizes in science. More »

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David Allis awarded $1 million grant from Starr Cancer Consortium

Allis leads one of five cancer research teams that are winners of $5 million in grant awards from The Starr Foundation’s Sixth Starr Cancer Consortium Grant Competition.
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David Allis to receive Gairdner Award

Allis, who studies DNA-packaging proteins called histones, is one of five scientists to be honored by the Gairdner Foundation for “fundamental discoveries that will have impact on human genetic development, cancer and other diseases.” More »

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Promising class of new cancer drugs causes memory loss in mice

Promising class of new cancer drugs causes memory loss in miceNew research shows that a family of experimental cancer drugs can induce neurological changes in mice. The findings underscore the need for more research to determine whether these compounds can enter the brain, where they potentially might cause side effects such as memory loss. More »

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Lifelong learning is made possible by recycling of histones, study says

Lifelong learning is made possible by recycling of histones, study saysResearchers have discovered a new mechanism that helps neurons make new connections with one another, the basis for learning. Their discovery focuses on one particular type of DNA-supporting protein, the histone H3.3, and its role regulating gene expression. More »

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Odd histone helps suppress jumping genes in stem cells, study says

Odd histone helps suppress jumping genes in stem cells, study saysThe histone variant H3.3 appears to help keep certain genetic elements called retrotransponsons in place in the genome, preventing potentially harmful mutations in mouse embryonic stem cells, researchers have found. This discovery reveals a basic mechanism for epigenetics, or the control of inherited traits through means other than DNA. More »

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Discovery links shift in metabolism to stem cell renewal

Discovery links shift in metabolism to stem cell renewalNew research links stem cell metabolism with those cells’ decision to pick a fate or renew themselves. In experiments, exposure to a key metabolite called alpha-ketoglutarate enhanced the renewal of mouse embryonic stem cells. More »

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Proceedings of the National Academy of Sciences USA 111: 7325-7330 (14-05-20)

Proceedings of the National Academy of Sciences USA 111: 7325-7330 Histone variant H3.3 is an essential maternal factor for oocyte reprogramming Duancheng Wen, Laura A. Banaszynski, Ying Liu, Fuqiang Geng, Kyung-Min Noh, Jenny Xiang, Olivier Elemento, Zev Rosenwaks, C. David … More »

Nature Genetics online: April 6, 2014

Nature Genetics online: April 6, 2014 Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations Pawel Buczkowicz, Christine Hoeman, Patricia Rakopoulos, Sanja Pajovic, Louis Letourneau, Misko Dzamba, Andrew Morrison, Peter Lewis, Eric Bouffet, … More »

Nature Chemical Biology online: March 30, 2014

Nature Chemical Biology online: March 30, 2014 Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark Lunzhi Dai, Chao Peng, Emilie Montellier, Zhike Lu, Yue Chen, Haruhiko Ishii, Alexandra Debernardi, Thierry Buchou, Sophie Rousseaux, Fulai Jin, Benjamin R. Sabari, Zhiyou … More »

Titia de Lange to receive Canada Gairdner International Award

de Lange is being recognized for her discovery of the mechanisms by which mammalian telomeres are protected from deleterious DNA repair and damage responses. The Gairdner is Canada’s highest scientific award and is considered among the most prestigious international prizes in science. More »

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In the News

Rockefeller University’s C. David Allis Wins Japan Prize   “Our major challenge, hopefully one taken up by the next generation of young scientists who are intrigued with epigenetics, will be to learn how to better harness the potential of the … More »

Cell 155: 107-120 (9-26-13)

Cell 155: 107-120 Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells Laura A. Banaszynski, Duancheng Wen, Scott Dewell, Sarah J. Whitcomb, Mingyan Lin, Nichole Diaz, Simon J. Elsässer, Ariane Chapgier, Aaron D. Goldberg, Eli Canaani, … More »

Cell online: July 16, 2013

Cell online: July 16, 2013 KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors Joshua C. Black, Amity L. Manning, Capucine Van Rechem, Jaegil Kim, Brendon Ladd, Juok Cho, Cristiana M. Pineda, Nancy Murphy, Danette … More »

Proceedings of the National Academy of Sciences USA online: July 1, 2013 Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells Sonja C. Stadler, C. Theresa Vincent, Victor D. Fedorov, Antonia … More »

Mechanism of mutant histone protein in childhood brain cancer revealed

Scientists in David Allis’s laboratory have shown how a mutated histone protein inhibits an enzyme, which normally keeps cell growth in check, and causes a rare form of pediatric brain cancer called DIPG. Their findings reveal a mechanism for inhibiting enzymes and could lead to the development of pharmaceuticals that mimic the action of these mutant proteins.

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Molecular Cell 49:1121-1133 (3-28-13)

Molecular Cell 49:1121-1133 The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation Jaehoon Kim, Jung-Ae Kim, Robert K. McGinty, Uyen T.T. Nguyen, Tom W. Muir, C. David Allis and Robert G. Roeder

Science online: March 28, 2013

Science online: March 28, 2013 Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma Peter W. Lewis, Manuel M. Müller, Matthew S. Koletsky, Francisco Cordero, Shu  Lin, Laura A. Banaszynski, Benjamin A. Garcia, Tom W. Muir, … More »

Wiley Prize in Biomedical Sciences awarded to Mike Young and colleagues

The researchers are being honored for their discovery of the molecular mechanisms governing circadian rhythm. This is the fourth major award Young and his colleagues have received in the past two years, including the Massry Prize, the Canada Gairdner International Award and the Louisa Gross Horwitz Prize from Columbia University. More »