Search Results for: Günter Blobel

Rockefeller University Cell Biologist, Günter Blobel, Wins 1999 Nobel Prize in Medicine

Rockefeller University cell biologist Günter Blobel, M.D., Ph.D., was awarded the 1999 Nobel Prize in Physiology or Medicine today. Blobel, the John D. Rockefeller Jr. Professor at The Rockefeller University and a Howard Hughes Medical Institute investigator, heads the Laboratory of Cell Biology. More »

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Nobel Laureate Blobel to Give First Medicine Prize Lecture Live Online

The first live Webcasts of the Nobel Prize lectures will take place on Wed., Dec. 8, 1999. This year’s laureate in Physiology or Medicine, Günter Blobel, M.D., Ph.D., of The Rockefeller University, will present his lecture, “Protein Targeting.” More »

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Atomic map reveals clues to how cholesterol is made

Atomic map reveals clues to how cholesterol is madeAn enzyme embedded in the cell membrane performs a crucial step in the complex process by which cells produce cholesterol. Researchers have examined the enzyme’s structure to better understand how it works. More »

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Proceedings of the National Academy of Sciences USA online: February 12, 2014

Proceedings of the National Academy of Sciences USA online: February 12, 2014 Structure of a myosin adaptor complex and pairing by cargo Hang Shi, Nimisha Singh, Filipp Esselborn and Günter Blobel

Proceedings of the National Academy of Sciences USA online: September 23, 2013

Proceedings of the National Academy of Sciences USA online: September 23, 2013 Structure and nucleic acid binding activity of the nucleoporin Nup157 Hyuk-Soo Seo, Bartlomiej J. Blus, Nina Z. Janković and Günter Blobel

Proceedings of the National Academy of Sciences USA online: March 11, 2013

Proceedings of the National Academy of Sciences USA online: March 11, 2013 Ring cycle for dilating and constricting the nuclear pore Sozanne R. Solmaz, Günter Blobel and Ivo Melcák  

Wiley Prize in Biomedical Sciences awarded to Mike Young and colleagues

The researchers are being honored for their discovery of the molecular mechanisms governing circadian rhythm. This is the fourth major award Young and his colleagues have received in the past two years, including the Massry Prize, the Canada Gairdner International Award and the Louisa Gross Horwitz Prize from Columbia University. More »

Proceedings of the National Academy of Sciences USA 109:16498-16503 (10-9-12)

Proceedings of the National Academy of Sciences USA 109:16498-16503 Structural evolution of the membrane-coating module of the nuclear pore complex Xiaoping Liu, Jana M. Mitchell, Richard W. Wozniak, Günter Blobel and Jie Fan

Pearl Meister Greengard Prize to be awarded to pioneering RNA researcher Joan Steitz

A prestigious Rockefeller University award for exceptional women scientists recognizes a pioneer in the field of RNA biology whose discoveries involved patients with a variety of autoimmune diseases. Steitz will receive the award from National Geographic Explorer in Residence Sylvia Earle at a ceremony in Rockefeller’s Caspary Auditorium on November 29. More »

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Michael W. Young receives Massry Prize

The prize recognizes outstanding contributions to the biomedical sciences and the advancement of health, and Young is being honored for his groundbreaking work on the molecular biology of circadian rhythms. Young’s work spans nearly three decades of research on the biological clocks that regulate our bodies’ patterns of sleep and wakefulness, metabolism and response to disease. More »

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Cell 147: 590–602 (October 28, 2011)

Cell 147: 590–602 Molecular Architecture of the Transport Channel of the Nuclear Pore Complex Sozanne R. Solmaz, Radha Chauhan, Günter Blobel and Ivo Melčák The nuclear pore complex encloses a central channel for nucleocytoplasmic transport, which is thought to consist of three … More »

Rockefeller University scientist Ralph Steinman, honored today with Nobel Prize for discovery of dendritic cells, dies at 68

Rockefeller University cell biologist Ralph M. Steinman, who discovered the immune system’s sentinel dendritic cells and demonstrated that science can fruitfully harness the power of these cells and other components of the immune system to curb infections and other communicable diseases, is this year’s recipient of the Nobel Prize in Physiology or Medicine, the Nobel Foundation in Stockholm, Sweden, announced today. He shares half the prize with Bruce A. Beutler and Jules A. Hoffmann. More »

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2011 Pearl Meister Greengard Prize to be awarded to McGill University memory researcher

Brenda Milner, a pioneer in the field of cognitive neuroscience whose discoveries revolutionized the understanding of memory, will be awarded the 2011 Pearl Meister Greengard Prize from The Rockefeller University.
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Polarized microscopy technique shows new details of how proteins are arranged

A key component of the nuclear pore complex — a Y-shaped cluster of proteins that helps determine what gets in and what stays out of a cell’s nucleus — was first photographed and modeled at Rockefeller in 2009. But fundamental questions about how the structures were aligned in relation to the rest of the 30-protein complex remained. Researchers at Rockefeller University have now developed a new technique that uses polarized light microscopy to help answer questions about the proteins’ orientation. More »

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“Promiscuous” protein interactions found in the nuclear pore complex

The NPC is the only way in or out of a cell’s nucleus. It plays a key role in cellular metabolism and signaling, and any malfunction in these pores can have lethal consequences. Now new research reveals further insights into the design of this evolutionarily ancient and little-understood transport machinery. The findings suggest that the nuclear pore complex takes on different formations to carry out its function. More »

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New research supports model for nuclear pore complex

The pores that control what passes in and out of the cell nucleus play a crucial role in the cell’s metabolism and signaling. Defects in structure and function of these gatekeepers, known as nuclear pore complexes, can have lethal consequences. New research reveals secrets about what may be a key design feature of these structures, a flexibility enabling the import and export of large molecules. More »

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Research suggests core nuclear pore elements shared by all eukaryotes

About 1.7 billion years ago, the cell nucleus burst onto the scene, sequestering the cell’s genetic material inside a protective inner membrane and setting the stage for the evolution of increasingly sophisticated creatures from yeast, say, to plants and human beings. Now research shows that one of the most basic design principles of this new eukaryotic life-form — the gatekeeper to the cell nucleus known as the nuclear pore complex — is largely shared across even the most distantly related eukaryotes. More »

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Research identifies 3D structure of key nuclear pore building block

New research into the molecular machine that filters all information traveling in or out of the cell nucleus contributes to an unfolding picture of cellular evolution that shows a common architecture for the nuclear pore complex (NPC) and the vehicles that transport material between different parts of the cell. Scientists have for the first time glimpsed in three dimensions the subcomplex of the NPC that is its key building block. More »

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Molecular machine turns packaged messenger RNA into a linear transcript

The nuclear pore complex is the only way in or out of the cell nucleus. This assembly also plays a key role in assuring the quality of the genetic information that passes through it. New research shows how one of the pore’s proteins magnetically couples with another molecule to form a machine that helps unpack messenger RNA. More »

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Cori Bargmann wins 2009 Lounsbery Award

Bargmann, who studies how C. elegans’s neural circuits develop, identifies the genes and neural pathways for its actions and investigates how sensory inputs regulate those circuits, is the recipient of this year’s Richard Lounsbery Award from the National Academy of Sciences. More »

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