Search Results for: Jean-Laurent Casanova

Jean-Laurent Casanova honored with the Korsmeyer Award

Jean-Laurent Casanova honored with the Korsmeyer AwardJean-Laurent Casanova is the recipient of the 2016 Stanley J. Korsmeyer Award. The award recognizes Casanova for discovering that vulnerability to life-threatening infectious illnesses in otherwise healthy children and young adults can arise from single-gene inborn errors. More »

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Jean-Laurent Casanova elected to the National Academy of Medicine

Jean-Laurent Casanova elected to the National Academy of MedicineWith his election, Casanova, who investigates the genetic underpinnings of unusual vulnerability to specific infectious diseases among young people, receives one of the highest honors within the field of medicine. Seventeen Rockefeller scientists are currently members of the academy of medicine. More »

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Leslie Vosshall and Jean-Laurent Casanova elected to the National Academy of Sciences

Jean-Laurent Casanova and Leslie Vosshall elected to the National Academy of Sciences

Vosshall, who investigates how sensory stimuli are perceived and processed, and Casanova, who studies the genetics of infectious disease susceptibility in children, are among the new members and foreign associates to be inducted into the Academy in 2015. With Vosshall and Casanova’s election, Rockefeller now boasts 36 members or foreign associates of the National Academy of Sciences among its current faculty.

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Jean-Laurent Casanova honored with 2014 Sanofi-Institut Pasteur Award

Jean-Laurent Casanova honored with 2014 Sanofi-Institut Pasteur AwardCasanova is recognized for discovering “holes” in the immune systems of otherwise healthy children that make them susceptible to specific, sometimes life-threatening infectious diseases. More »

Jean-Laurent Casanova to receive 2014 Robert Koch Award

Jean-Laurent Casanova to receive 2014 Robert Koch Award Casanova is honored for his work on host genes and their products in infectious diseases. His lab is interested in why some children develop severe infectious diseases after coming into contact with certain pathogens, while most other children do not. More »

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Jean-Laurent Casanova appointed HHMI investigator

Casanova, whose research established for the first time that a predisposition to infectious diseases in children can be genetically determined, has been named one of 27 new investigators with the Howard Hughes Medical Institute. His appointment brings the total number of Rockefeller scientists supported by HHMI to 16. More »

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Jean-Laurent Casanova to receive 2012 Milstein Award

The award is bestowed upon a leading biomedical research scientist who has made outstanding contributions to interferon and cytokine research, either in a basic or applied field. Casanova’s studies have important clinical implications, as they provide a rationale for developing new therapeutic approaches based on an understanding of the host component of infectious diseases. More »

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Jean-Laurent Casanova honored with Belgium’s highest scientific prize

Jean-Laurent Casanova has received the 2011 InBev-Baillet Latour Health Prize, Belgium’s most important scientific prize, for his pioneering work on the identification of genes that predispose for human infectious disease. More »

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In the News – Newsweek – Casanova

To fight superbugs, scientists are turning toward antibodies   “‘The bottom line is that the bacteria now develop resistance to anti-infectious agents faster than we can develop the anti-infectious agents,’ says Dr. Jean-Laurent Casanova, a professor at Rockefeller University who … More »

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In the News – NPR – Casanova

A single gene may determine why some people get so sick with the flu “The study helps explain genetic variation changes the way that people fight off viruses. ‘The response to influenza is genetically impaired,’ says [Jean-Laurent] Casanova. He’s hoping … More »

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Charles Rice wins Belgium’s highest scientific prize

Charles Rice wins Belgium’s highest scientific prizeRice has received the 2016 InBev-Baillet Latour Health Prize for his fundamental discoveries in the field of infectious diseases. The award, given by the Baillet Latour Fund to recognize outstanding contributions in biomedical research for the benefit of human health, is Belgium’s most important scientific prize. More »

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Researchers develop gene-filtering tool to identify disease-causing mutations

Genes that are frequently mutated in the general population are unlikely to cause disease, because variations of these genes are often found in healthy people. A new tool from researchers at Rockefeller uses this concept to help scientists identify the mutations in genes that matter. More »

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Mutations in a single gene underlie vulnerability to two unrelated types of infections

Mutations in a single gene underlie vulnerability to two unrelated types of infectionsResearchers have identified a surprising case in which defects in a single immune gene render children susceptible to two very different diseases: aggravating, but treatable fungal infections, as well as invasive and potentially fatal bacterial disease. This finding suggests a dual role for that gene, RORC, in human immunity to infection. More »

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Charles Rice to receive 2015 Robert Koch Award

Charles Rice to receive the 2015 Robert Koch AwardGranted by the Robert Koch Foundation, the annual award is one of Germany’s most distinguished scientific prizes and honors extraordinary accomplishments in infectious disease research. It recognizes Rice’s work on understanding the lifecycle of the hepatitis C virus and laying the groundwork for effective therapeutic developments. More »

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Genetic mutation helps explain why, in rare cases, flu can kill

Genetic mutation helps explain why, in rare cases, flu can killA small number of children who catch the influenza virus fall so ill they end up in the hospital even while their family and friends recover easily. New research from Rockefeller helps explain why: a rare genetic mutation that prevents the production of a critical protein, interferon, that is needed to fight off the virus. More »

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Key to blocking influenza virus may lie in a cell’s own machinery

Key to blocking influenza virus may lie in a cell’s own machineryResearchers have found that the immune system fights a flu infection by turning off cellular enzymes the virus needs to put the final touches on new viral particles. The unfinished particles cannot spread infection to new cells. More »

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Single gene links susceptibility to rare infections with predisposition to autoimmune disease

Single gene links susceptibility to rare infections with predisposition to autoimmune diseaseWhen scientists scanned the brains of patients who lack a particular immune protein, they saw calcium deposits linked with certain diseases that occur as a result of harmful and unnecessary inflammation. More »

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A new web tool effectively prioritizes disease-causing genes by biological distance

With the Human Gene Connectome, an investigator can rank potential disease-causing genes based on a new metric called biological distance. This tool is now available online thanks in part to the work of two high school students. More »

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Journal of Experimental Medicine 210: 2739-2753 (11-18-13)

Journal of Experimental Medicine 210: 2739-2753 Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells Elissa K. Deenick, Danielle T. Avery, Anna Chan, Lucinda J. Berglund, Megan L.  Ives, Leen Moens, … More »

Immunity 39: 676-686 (10-17-13)

Immunity 39: 676-686 An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis Bertrand Boissonsend, Chenhui Wang, Vincent Pedergnana, Ling Wu, Sophie Cypowyj, Michel Rybojad, Aziz Belkadi, Capucine Picard, Laurent Abel, Claire Fieschi, Anne Puel, Xiaoxia Li … More »