Search Results for: Mary Jeanne Kreek

Variations in key genes increases Caucasians’ risk of heroin addiction

By scanning a large swath of the human genome, Rockefeller University researchers identify tiny variations in a few genes that can influence some people’s likelihood of developing heroin dependency. The work, which raises questions about race and personalized medicine, sheds new light on the role of genetics in addictive diseases. More »

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Abuse of painkillers can predispose adolescents to lifelong addiction

No child aspires to a lifetime of addiction. But their brains might. Now, Rockefeller University researchers reveal that adolescent brains exposed to the painkiller Oxycontin can sustain lifelong changes in their reward system that increase the drug’s euphoric properties, and make them more vulnerable to the drug’s effects later in adulthood. More »

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Slightly abnormal blood test may point to a ‘silent’ form of hepatitis B

In the first study to screen for multiple markers of hepatitis A, B and C in patients entering a single drug-treatment program, researchers reveal that 20 percent who had hepatitis B in the past may have a silent form of the virus. The findings, which reignite an ongoing public health debate, heighten justification for treating this potentially infectious viral renegade. More »

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Rockefeller University receives $45 million NIH grant for clinical, translational science

With the award, Rockefeller University has established the Center for Clinical and Translational Science, which will bring together translational researchers at Rockefeller University and its affiliated and collaborating institutions. In addition, the award will support a new training program for physician-scientists entering careers in translational research. More »

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Animal study suggests two amino acids may modulate addictive behavior

For some, living without alcohol, cigarettes or even coffee is a daily struggle. Others can give up their vices without ever looking back. From a biological standpoint, the difference may be as slight as a single amino acid, suggests new research from the Rockefeller University laboratories of Mary Jeanne Kreek and Paul Greengard. By tracking individual amino acids in a single protein in mice, and noticing how they change when the mice are given access to cocaine, scientists are beginning to understand how an individual’s underlying genetics can reinforce his addictive behavior. More »

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New genetic sequencing technique reveals possible genetic protection from heroin addiction

New research from the laboratory of Mary Jeanne Kreek at Rockefeller University uses a novel sequencing approach to show that even very tiny differences within genes may help protect someone from heroin addiction, and perhaps addiction disorders in general. More »

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Rockefeller University researchers are changing the face of addiction treatment

People addicted to heroin, alcohol and other drugs of abuse often fail to stay clean because they won’t go to or won’t stay in treatment. Reporting in the January issue of the Journal of Substance Abuse Treatment, Scott Kellogg, Ph.D., and Mary Jeanne Kreek, M.D., at The Rockefeller University, and colleagues at the New York City Health and Hospitals Corporation (HHC) and at Johns Hopkins University, show that a treatment approach called contingency management improves patients’ motivation to stay in treatment and increases their therapeutic progress. More »

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New test for drug and alcohol addiction focuses solely on time of heaviest use

A new survey can quickly test for addiction to cocaine, heroin and alcohol simply by asking about the time in the person’s life when he or she was drinking or using these substances the most, according to a study by Rockefeller University researchers. More »

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Nature’s Own Antidote to Cocaine

Some people’s brains may harbor their own built-in defense system against the addictive powers of cocaine. According to new research at The Rockefeller University, a naturally occurring brain opiate called dynorphin may, in certain individuals, serve as an antidote to counter the pleasurable, yet dangerous, effects of cocaine. More »

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Ten Science Outreach students reach semifinals of Intel Science Talent Search

Ten out of the 60 high school students who participated in RU’s Science Outreach Program have been named semifinalists in the Intel Science Talent Search (formerly the Westinghouse Science Talent Search). This program, now in its 59th year, is one of the most prestigious science awards for high school students in the country. More than 70 percent of the former finalists have gone on to earn Ph.D.s or M.D.s; five have won Nobel Prizes. More »

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Subtle Changes in Brain Receptor Gene May Have Significant Consequences for Addiction

Scientists have identified five slightly different versions of the mu opioid receptor gene that alter the activity of a molecule called b-endorphin, a member of the endorphin family of proteins that can numb pain, create feelings of euphoria or increase energy, which opiates and other drugs of analgesia and addiction do as well. The findings, reported by researchers from The Rockefeller University, Indiana University School of Medicine and University of Cincinnati College of Medicine in the August 4 Proceeding of the National Academy of Sciences, show for the first time that these altered molecules are distributed differently among ethnic groups and have implications for normal physiology, therapeutics and vulnerability to develop or protect from diverse diseases involving mu opioid receptors, including the addictive diseases. More »

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Messing With Your Head: Cocaine Found to Affect Endorphin Gene in Brain

The effects of the addictive drug cocaine result, in part, from altering the activity of a gene in the brain, report scientists from The Rockefeller University in the May Molecular Brain Research. More »

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