Search Results for: Sanford Simon

Grant awarded to Sanford Simon will fund research to treat rare liver cancer

  NEW YORK (March 8, 2017) — Dr. ­Sanford Simon, head of the Laboratory of Cellular Biophysics at Rockefeller University, has been awarded a $600,000 grant by the Fibrolamellar Cancer Foundation (FCF) to develop a therapy for fibrolamellar hepatocellular carcinoma. … More »

Intellectual property on pediatric cancer is dedicated to the public

Intellectual property resulting from the discovery of specific DNA mutations linked to a rare and often deadly type of adolescent liver cancer, fibrolamellar hepatocellular carcinoma, has been dedicated to the public by the institutions that made the discovery, The Rockefeller University and the New York Genome Center, in the hope of accelerating progress toward the delivery of diagnostics and therapies for the devastating disease. More »

In the News

Obama Meets 18-Year-Old Cancer Researcher, Among Other Science-Fair Achievers   “President Barack Obama lauded whiz kids at the White House Science Fair on Tuesday, including Elana Simon [daughter of Sanford Simon], an 18-year-old who helped research a rare liver cancer … More »

After rare cancer diagnosis, teen works to identify a genetic link to her own disease

The New York Genome Center and The Rockefeller University’s finding of a mutation that is present in 15 out of 15 patients suggests new opportunities for diagnosis and treatment of cancer, and leads to a high profile Science publication NEW … More »

Researchers discover unusual genetic mutation linked to adolescent liver cancer

In the race for better treatments and possible cures, rare diseases are often left behind. In a collaboration of researchers at The Rockefeller University, Memorial Sloan Kettering Cancer Center and the New York Genome Center, an unusual mutation has been found that is strongly linked to one such disease: a rare liver cancer that affects teens and young adults. More »

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In the news

Teen helps scientists study her own rare disease   “Making that idea work required a lot of help from real scientists: Her father, [Sanford Simon], who runs a cellular biophysics lab at The Rockefeller University; her surgeon at Memorial Sloan-Kettering … More »

Scientists image a single HIV particle being born

For some, the saying “seeing is believing” has taken on a new meaning. In research to be published in the May 25 advance online issue of Nature, scientists at Rockefeller University and the Aaron Diamond AIDS Research Center have become the first to see, in real time and in plain sight, an HIV particle being born. The images, created using a technique that illuminates only the surface of the cell, where the virus assembles, have the potential to help researchers develop new treatments for AIDS. More »

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Viewing dye-packed vesicles causes them to explode

A fluorescent marker, long used in imaging to help researchers watch membrane-bound vesicles as they exit a cell, can actually cause the vesicles to break open as soon as they’re hit with light from a microscope. New research describes how to differentiate a microscopy side effect from the cell’s true process. More »

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Cellular transport vehicles caught on film

They look like soccer balls — only much smaller. They are tiny transport vehicles used by cells to import biological cargo and, for the first time, Rockefeller University researchers have caught them on film swimming across the surface of cells. More »

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First images of protein export in cells illuminate structural “highways” called microtubules as sole conduits of protein cargo

For the first time, scientists have viewed — and recorded on camera — the final pathway followed by a protein as it exits the body cell that created it. Once released from a cell, a protein is free to perform its duties as a neurotransmitter, hormone, cell surface receptor, or one of the many other “work horses” that function outside of body cells every second of the day. More »

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Observing Proteins and Cells in the Wild

Imagine if molecular and cell biologists could watch proteins and cells at work in their natural habitat in the same way that wildlife biologists observe animals in the wild. They’d sit back and witness firsthand their microscopic subjects’ daily routines, interactions and movements, and the places they prefer to be. More »

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Rockefeller and Michigan State Scientists Identify Dangers of Tamoxifen and Recommend Simple Corrective Measures

A team of researchers at The Rockefeller University and Michigan State University has identified a biochemical mechanism that may cause the potentially life-threatening side-effects associated with use of the anti-breast cancer drug tamoxifen, and has recommended steps to reduce the danger. The findings are reported in the June 25 issue of the Journal of Biological Chemistry. More »

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Rockefeller University Researchers Find Large Hole-Forming Protein in Bacteria — A Potential Achilles’ Heel?

Researchers at The Rockefeller University have shown for the first time that a protein called pIV forms a hole in the outer membrane of the bacterium E. coli to allow passage of large molecules. The finding, reported in the May 28 issue of the journal Science, may allow researchers to exploit the bacterium’s Achilles’ heel to better deliver antibiotics. More »

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A newly discovered molecular feedback process may protect the brain against Alzheimer’s

A newly discovered molecular feedback process may protect the brain against Alzheimer’s Researchers have identified within neurons a series of molecular interactions — known as a pathway — that can dampen the production of the Alzheimer’s protein amyloid-β. These results suggest a new route in the search for therapies for this degenerative disease. More »

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Science 343: 1010-1014 (14-2-28)

Science 343: 1010-1014 Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma Joshua N. Honeyman, Elana P. Simon, Nicolas Robine, Rachel Chiaroni-Clarke, David G. Darcy, Irene Isabel P. Lim, Caroline E. Gleason, Jennifer M. Murphy, Brad R. Rosenberg, … More »

Polarized microscopy technique shows new details of how proteins are arranged

A key component of the nuclear pore complex — a Y-shaped cluster of proteins that helps determine what gets in and what stays out of a cell’s nucleus — was first photographed and modeled at Rockefeller in 2009. But fundamental questions about how the structures were aligned in relation to the rest of the 30-protein complex remained. Researchers at Rockefeller University have now developed a new technique that uses polarized light microscopy to help answer questions about the proteins’ orientation. More »

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Imaging studies reveal order in programmed cell death

In order to thrive, the human body orchestrates a mass suicide of about 10 billion potentially dangerous cells a day. New research takes a closer look at programmed cell death — called apoptosis — and finds order in this process, once thought to be an erratically timed, sudden collapse. More »

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Imaging study shows HIV particles assembling around its genome

The genesis of one the planet’s most lethal viruses, HIV, has been caught on tape. New imaging experiments show individual HIV genomes — strands of RNA — docking on the inner membrane of an infected cell wall as they are ensconced by HIV structural proteins. More »

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Cells use import machinery to export their goods as well

Cells use bubbles called vesicles to ferry cargo to and from the membrane. Scientists long believed that this importing and exporting were independent processes. But by imaging individual vesicles as they are fusing with the cell membrane, researchers reveal that these processes have a lot in common: Certain molecules handle cargo moving in both directions. More »

Viral detectives: Researchers track down the location of HIV-1 assembly in human cells

New research by Rockefeller University and ADARC scientists pinpoints the location of HIV-1 assembly in human immune cells. Although the assembly site had long been a topic of dispute, the researchers show conclusively that the virus is being built in the cells’ plasma membranes and not, as many had supposed, in internal cellular compartments called endosomes. More »

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