Search Results for: Tarun Kapoor

Tarun Kapoor to receive Irving Sigal Young Investigator Award

The award recognizes Dr. Kapoor’s work combining chemical and biological approaches to dissect mechanisms of cell division. and will be presented at The Protein Society’s annual symposium in August.
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Rockefeller scientists pioneer new method to determine mechanisms of drug action

Sarah Wacker, Tarun Kapoor and their colleagues have hit on a new method for determining a drug’s molecular target that takes the guesswork out of the equation. The approach makes use of RNA sequencing and advances in data processing technologies to examine all of the differences between a drug-resistant cell and a normal cell and pinpoint the change most likely to cause resistance, which may suggest the drug’s target. More »

Measuring the strength needed to move chromosomes

The tiny meiotic spindle, which teases apart chromosomes during cell division, plays a crucial role in maintaining an accurate replication of the genome. Researchers have used biochemical experiments to study it extensively, but until now, no one has been able to examine its mechanical properties. Rockefeller University professor Tarun Kapoor and colleagues have devised a system to probe these microscopic spindles and have used it for the first time to measure the structure’s stiffness and deformability. More »

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Rockefeller announces tenure appointments of two faculty

Rockefeller University president Paul Nurse has announced the tenure promotion of two faculty members: Tarun Kapoor, a researcher in cell division and head of Rockefeller’s Laboratory of Chemistry and Cell Biology, and Michael P. Rout, head of the Laboratory of Cellular and Structural Biology, which focuses on the nuclear pore complex. Both were promoted from associate professor to professor. More »

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A compound that stops cells from making protein factories could lead to new antifungal drugs

A newly identified compound shows promise for fighting fungal infectionsRibosomes manufacture all the protein cells need, making them an appealing target for researchers seeking to develop new medicines. New research in yeast has identified a compound that prevents the assembly of ribosomes, raising hopes for drug development. More »

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Researchers probe the physical forces involved in creating the mitotic spindle

Researchers probe the physical forces involved in creating the mitotic spindleScientists have gained new insight into the formation of the spindle, which is the molecular machine that divides up genetic material prior to cell division. Their work focuses on the motor protein, kinesin-5, which helps to organize the spindle’s filaments. More »

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New findings shed light on fundamental process of DNA repair

New findings shed light on fundamental process of DNA repairScientists have identified a new component of the molecular machinery a cell uses to repair damaged DNA. The discovery adds important knowledge about a fundamental life process that protects from diseases such as cancer. More »

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Expert in cryo-electron microscopy to join Rockefeller faculty

Expert in cryo-electron microscopy to join Rockefeller facultyThomas Walz, a structural biologist, will establish the Laboratory of Molecular Electron Microscopy as of September 1. Walz uses cutting edge tools in electron microscopy to examine macromolecular complexes and proteins embedded in cellular membranes, and he will help biologists from other fields use the same techniques for their research. More »

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Rockefeller postdoc Stephen Brohawn named Blavatnik Award regional finalist

Rockefeller postdoc Stephen Brohawn named Blavatnik Award regional finalistBrohawn, a member of Roderick MacKinnon’s Laboratory of Molecular Neurobiology and Biophysics, studies how proteins called mechanosensitive ion channels sense mechanical forces. He is one of nine finalists from the New York region. More »

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Friction harnessed by proteins helps organize cell division

Researchers have found that the fastener proteins that organize cell division can harness the movement around them to do their work. Movement of filaments within the structure responsible for cell division can cause some of these proteins to shuffle along the path of least resistance and into position. More »

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Jonathan Fisher receives Blavatnik Award for Young Scientists

Fisher is a postdoc in James Hudspeth’s Laboratory of Sensory Neuroscience studying the biophysics and neurophysiology of the auditory system. He is one of seven winners of the prize, which is given to faculty and postdocs in the tri-state area. More »

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Two Rockefeller postdocs win Blavatnik Awards

Two Rockefeller University postdoctoral fellows have been named winners in the 2012 Blavatnik Awards for Young Scientists competition from The New York Academy of Sciences. Andrey Feklistov, from Seth Darst’s Laboratory of Molecular Biophysics, and Nicholas Stavropoulos, from Michael Young’s Laboratory of Genetics, are among 9 winners and 2 finalists. The awards are given to researchers under the age of 42 who demonstrate highly innovative, impactful and interdisciplinary accomplishments in the life sciences, physical sciences, mathematics and engineering. More »

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Studies describe key role for a protein in cell division

New research shows how one protein, PRC1, acts in the penultimate stage of cell division to help form the architectural structures, called central spindles, needed before the cell can split in two. More »

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Winrich Freiwald named Pew Scholar

A cognitive neuroscientist, who uses imaging techniques to study the parts of the brain responsible for visual processing, is the recipient of a prestigious Pew Scholars award. More »

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Shaham and Chalasani named winners of 2009 Blavatnik Awards

Associate Professor Shai Shaham and Postdoctoral Fellow Sreekanth H. Chalasani, who were named finalists in the third annual competition in September, were honored last night with six other winners at the New York Academy of Sciences’ Science and the City Gala. More »

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Two Rockefeller scientists named finalists for Blavatnik Awards for Young Scientists

Associate Professor and head of laboratory Shai Shaham and Postdoctoral Fellow Sreekanth H. Chalasani are finalists in the third annual competition administered by the New York Academy of Sciences. More »

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Four Rockefeller researchers named finalists in Blavavtik Awards for Young Scientists

Head of laboratory Tom W. Muir, postdocs Valerie Horsley and Andreas Keller and former postdoc Matthew Evans have been named finalists for the second annual Blavatnik Awards for Young Scientists. Established by the New York Academy of Sciences and the Blavatnik Charitable Foundation, the awards recognize the contributions of young scientists and engineers in New York, New Jersey and Connecticut. More »

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Dividing cells find their middle by following a protein ‘contour map’

Self-organization keeps schools of fish, flocks of birds and colonies of termites in sync. It’s also, according to new research, the way cells regulate the final stage of cell division. Scientists at Rockefeller University have shown that a protein-chemistry-based contour map, which helps individual proteins locate the center of their cell without direction from a “master organizer,” is key to ensuring accurate division during mitosis. More »

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‘Hitchhiking’ chromosomes yield new theory of cell division

From the moment the cell was discovered, scientists have been dissecting the methodical, multi-step process by which they duplicate themselves. This week, Rockefeller researchers studying one component of this process — how a cell’s chromosomes move in preparation for division — announce a discovery that overturns current cell-division theory. More »

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Cellular Two Step

Following the often-quoted advice of Yogi Berra — “You can observe a lot by just watching” — Rockefeller University scientists show that nerve cells in the developing brains of humans and other mammals move in a two-part “step” led by a structure within the cell called the centrosome. Once the centrosome, the key organizing point for the cell’s internal skeleton, moves forward, the cell nucleus follows. The Rockefeller scientists produced time-lapse movies that show nerve cell migration in unprecedented clarity and detail. More »

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