Search Results for: Titia de Lange
Researchers at The Rockefeller University and the Howard Hughes Medical Institute have identified the mechanism by which the cell’s protein recycler, the proteasome, ramps up its activity to take care of unwanted and potentially toxic proteins. The finding, which has implications for treating muscle wasting and neurodegeneration, also suggests that small molecule inhibitors of this mechanism may be clinically useful in treating multiple myeloma. More »
Davoli, a native of Italy, studied a new mechanism of tetraploidization that is induced by dysfunctional telomeres. The Weintraub Awards recognize quality, originality and significance of thesis research. More »
Two Rockefeller University scientists are among 11 winners of the first annual Breakthrough Prize in Life Sciences, an award established by six tech entrepreneurs dedicated to advancing breakthrough research. At $3 million each, the prizes are worth more than twice the amount of the Nobel. They were created to recognize excellence in research aimed at curing intractable diseases and extended human life.
Administered by a new non-profit organization, the Breakthrough Prize in Life Sciences Foundation, the prize is founded by Art Levinson, chairman of the board of Apple and former CEO of Genentech; Sergey Brin, co-founder of Google Inc.; Anne Wojcicki, co-founder of 23andMe; Mark Zuckerberg, founder and CEO of Facebook, and his wife Pricilla Chan; and Yuri Milner, founder of the Russian internet company Mail.ru. More »
Proceedings of the National Academy of Sciences USA online: January 22, 2013 Role of 53BP1 oligomerization in regulating double-strand break repair Francisca Lottersberger, Anne Bothmer, Davide F. Robbiani, Michel C. Nussenzweig and Titia de Lange
Science online: January 10, 2013 53BP1 regulates DSB repair using Rif1 to control 5′ end resection Michal Zimmermann, Francisca Lottersberger, Sara B. Buonomo, Agnel Sfeir and Titia de Lange
Two Rockefeller University faculty have been awarded the NIH Director’s Transformative Award and three are being given New Innovator Awards.
A prestigious Rockefeller University award for exceptional women scientists recognizes a pioneer in the field of RNA biology whose discoveries involved patients with a variety of autoimmune diseases. Steitz will receive the award from National Geographic Explorer in Residence Sylvia Earle at a ceremony in Rockefeller’s Caspary Auditorium on November 29. More »
A detailed analysis of a large panel of so-called ALT cell lines shows that they frequently undergo chromosomal changes and are impaired in their ability to detect and repair damage in their DNA. The work suggests a mechanism by which 10 to 15 percent of human cancers develop. More »
Cell 150: 39-52 Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST Peng Wu, Hiroyuki Takai and Titia de Lange
Cancer Cell 21: 765-766 Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells Teresa Davoli and Titia de Lange
Science 336: 593-597 Removal of shelterin reveals the telomere end-protection problem Agnel Sfeir and Titia de Lange
De Lange is honored for her work on telomeres, the protective DNA sequences located at the tips of chromosomes which play a crucial role in such processes as ageing and cancer.
Scheid is one of 13 awardees, all advanced graduate students at or near the completion of their studies in the biological sciences and chosen for the quality, originality and significance of their thesis research.
Brenda Milner, a pioneer in the field of cognitive neuroscience whose discoveries revolutionized the understanding of memory, will be awarded the 2011 Pearl Meister Greengard Prize from The Rockefeller University.
Rockefeller researcher is honored for her research on mechanisms that help maintain genome stability. More »
Rockefeller University scientists Robert B. Darnell, head of the Laboratory of Molecular Neuro-oncology, and Titia de Lange, head of the Laboratory of Cell Biology and Genetics, have been elected to the Institute of Medicine, the health and medicine branch of the National Academy of Sciences. More »
Agnel Sfeir, a postdoctoral fellow in Titia de Lange’s Laboratory of Cell Biology and Genetics, has been named a finalist in the fourth annual Blavatnik Awards for Young Scientists competition, which recognizes the contributions of young scientists and engineers in New York, New Jersey and Connecticut. More »
Titia de Lange is the 50th annual recipient of the American Association of Cancer Research’s award to an individual with outstanding recent accomplishments in basic cancer research. More »
The head of Rockefeller University’s Laboratory of Cell Biology and Genetics has received a $400,000 grant from the American Cancer Society and has been named an American Cancer Society Research Professor. The five-year grant, which is effective January 1, 2010, will fund de Lange’s continuing research on telomeres, the strings of extra DNA that cap and protect the ends of chromosomes through numerous cycles of cell division. More »
Although telomeres are fragile, they don’t have to be handled with care. Researchers at Rockefeller University now show that what keeps our fragile telomeres from falling apart is a protein known as TRF1 that ensures the smooth progression of DNA replication to the end of a chromosome. The work not only shows how telomeres help chromosomes protect their vulnerable ends but also reveals how the genome is made more stable by them. More »