Intellectual property resulting from the discovery of specific DNA mutations linked to a rare and often deadly type of adolescent liver cancer, fibrolamellar hepatocellular carcinoma, has been dedicated to the public by the institutions that made the discovery, The Rockefeller University and the New York Genome Center, in the hope of accelerating progress toward the delivery of diagnostics and therapies for the devastating disease. More »
The rankings, released by the European Commission-funded U-Multirank survey, placed Rockefeller among the top five institutions in five key categories. Across the entire set of rankings, which incorporates data from 1,200 institutions, Rockefeller was the only institution to receive this many top slots.
A small number of children who catch the influenza virus fall so ill they end up in the hospital even while their family and friends recover easily. New research from Rockefeller helps explain why: a rare genetic mutation that prevents the production of a critical protein, interferon, that is needed to fight off the virus. More »
A detailed look at the African sleeping sickness parasite’s strategy for evading its hosts’ immune systems revealed that the blood parasites assume a surprising diversity of protein coat disguises. In fact, the number of disguises necessary to maintain a long-term infection appears to exceed the functional genes that encode them. More »
Rockefeller University researchers have successfully harnessed a technique, CRISPR-Cas9 editing, to use in an important and understudied species: the mosquito, Aedes aegypti, which infects hundreds of millions of people annually with the deadly diseases chikungunya, yellow fever, and dengue fever. More »
Tags: aedes aegypti, chikungunya, CRISPR, CRISPR-Cas9, dengue fever, gene editing, Laboratory of Neurogenetics and Behavior, Leslie B. Vosshall, Leslie Vosshall, mosquitos, yellow fever
New research reveals how cells sort out the RNA molecules destined to become gene-regulating microRNAs by tagging them. Because microRNAs help control processes throughout the body, this discovery has wide-ranging implications for development, health and disease, including cancer.
Researchers identify a molecular bridge between amyloid-β and chronic inflammation, two hallmarks of Alzheimer’s. That bridge, a molecular cascade known as the contact system, suggests the possibility of a simple blood test that could diagnose the disease early and non-invasively.
Experiments placed Sox9 at the crux of a shift in gene expression associated with hair follicle stem cell identity. The molecule first makes stem cell genes accessible so they can become active, then recruits other molecules that promote the expression of these genes in stem cells found at the base of the hair follicle. More »
Only a single treatment produced what researchers describe as “rapid, substantial, and durable clinical improvement” in patients. This raises the prospect of a treatment that could put this autoimmune disease of the skin into long-term remission. More »
The first mathematicians to receive the prize for writing about science, Strogatz and Stewart will be honored at a ceremony in Caspary Auditorium on the evening of Monday, March 30. More »
In experiments, the state of a simple brain network determined the likelihood a worm would move toward a delicious smell or ignore it. Scaled up to account for the more nuanced behaviors of humans, the research may suggest ways in which our brains process competing motivations. More »
Both the virus and liver cells need the microRNA molecules the liver produces to regulate its genes. Researchers found that by co-opting one microRNA, the virus may cause changes in gene expression in liver cells. More »
The prize, awarded by MIT’s McGovern Institute, honors outstanding achievements in neuroscience. It recognizes Gilbert’s work on visual perception and brain plasticity. More »
Researchers found that exposure to the signal TGF-β causes changes in mouse tumor stem cells that help them evade a widely used anti-cancer drug. This did not happen to cells that did not receive TGF-β. More »
The enzyme Cas9 is well known for its ability to make precise cuts in a genome. New research reveals a new role for Cas9 in its native bacteria: helping the microbial immune system acquire a memory of an invading virus. More »
As part of an effort to identify DNA found throughout New York City, students in Rockefeller’s Science Outreach Program have been swabbing surfaces in the subway system. Their work has turned up bacteria resistant to two common antibiotics. More »
Considered one of the most prestigious prizes in medicine, the Wolf Prize recognizes Ravetch’s work on the molecular basis of the immune response, including the Fc receptor system that mediates antibody function in disease and health. More »