New study of psoriatic cells could fire up the study of inflammation

Psoriasis is one of humanity’s oldest know diseases and one of the more widespread, affecting 2 percent of the U.S. population. But it remains largely a mystery. New work identifies markers that define two types of dendritic cells found in psoriatic lesions, findings that will help scientists isolate and study the most troublesome inflammatory variety. More »

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New faculty member seeks secrets of intestinal immunity

Newly named assistant professor Daniel Mucida studies the balance between tolerance and immunity by observing what happens in the intestinal tract. It’s there that the body must cope with a constant stream of foreign antigens from our food as well as a flourishing ecosystem of bacteria, viruses and parasites. More »

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Leslie Vosshall promoted to professor

A neurobiologist whose research focuses on the mechanism of smell has been granted tenure by the university’s Board of Trustees. More »

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Rockefeller immunologist receives Gates Foundation Grand Challenges grant

Jean-Laurent Casanova will launch a new project aimed at understanding how a collection of genetically diverse errors in immunity leads to susceptibility to tuberculosis in children under 15 years old. More »

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Scientists identify potential new target for schizophrenia drugs

A protein that boosts the signaling power of a receptor involved in relaying messages between brain cells may provide a new target for the development of treatments for schizophrenia and Parkinson’s disease. More »

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Ralph M. Steinman receives 2010 Heineken Prize for Medicine

Rockefeller immunologist Ralph M. Steinman receives Dutch prize for his discovery of the dendritic cell and its role in the immune response. More »

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Paul Nurse to resign as Rockefeller president to become president of Royal Society of London in December

Paul Nurse, a Nobel Prize-winning biologist, has served as Rockefeller University’s president since 2003. More »

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Titia de Lange receives AACR Clowes Award

Titia de Lange is the 50th annual recipient of the American Association of Cancer Research’s award to an individual with outstanding recent accomplishments in basic cancer research. More »

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Cell division orchestrated by multiple oscillating proteins, new research finds

New research takes the study of biological rhythms, like the heart beat, to a new level: the cell cycle. Scientists at Rockefeller University have proposed that the orderly succession of events in cell division is governed by a master oscillator, coordinating with independent oscillators that control individual events. Their model suggests that this orderly orchestration is analogous to how our circadian rhythm syncs with the light-dark cycle in our environment. More »

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New gene for hair loss identified

Researchers have discovered a gene involved in hair loss that may lead to new, non-hormonal therapies for baldness. The work, by researchers at Rockefeller, Columbia and Stanford universities, reveals that a mutation in a gene called APCDD1 inhibits a signaling pathway that was known to affect hair growth in mice but never before in humans. More »

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New probe technology illuminates the activation of light-sensing cells

vThrough ingenious combinations of roughly 20 amino acids, the basic building blocks of life, genes can build the proteins that comprise everything from the simplest bacteria to the human brain. In new research published today in Nature, scientists unveil a new technique to illuminate the function of those proteins. The method of genetically targeting a non-natural amino acid to specific locations within a protein could theoretically be adapted to place a fluorescent probe at any position in any protein in a mammalian cell. More »

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Rockefeller University names Martin Rees 2009 Lewis Thomas Prize winner

Cosmologist and astrophysicist Martin Rees has been named the recipient of Rockefeller University’s Lewis Thomas Prize for Writing about Science for 2009. More »

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Leslie Vosshall, Paul Greengard win Dart/NYU biotech awards

Rockefeller scientists receive honors for their contributions to next-generation insect repellents and drugs to treat neurological diseases. More »

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Rockefeller particle physicists already at work as LHC particle collider research starts

A team of high-energy physicists at Rockefeller is part of a more than 2,000-strong group of physicists working on the CMS experiment at the Large Hadron Collider, the world’s largest and highest-energy particle accelerator. The LHC research program aims to reproduce the conditions that were present a fraction of a second after the Big Bang. More »

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New book by population biologist asks why we educate children

Rockefeller University’s Joel E. Cohen hopes to launch an international conversation on the rationales for educating children, informed by diverse perspectives on why education should be a goal at all.v More »

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Scientists pinpoint source of recurrent yeast infections in autoimmune syndrome

It turns out that the immune system can create its own infections. Scientists now report that the immune-fighting proteins that keep yeast in check in healthy immune systems are under siege in patients with a rare autoimmune disorder known as APS-1. By pinpointing the cause of candidiasis in these patients, the finding paves the way for treating these fungal infections with drugs that are already out in the market. More »

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Scientists track variant of gene-regulating protein in embryonic stem cells

The path to fully developed cells from embryonic stem cells requires that the right genes are turned on and off at the right times. New research from Rockefeller University shows that tiny variations between gene-regulating histone proteins play an important role in determining how and when genes are read. The finding shows that each region of the genome may be even more specialized than previously expected and may open a new avenue of investigation regarding the mysterious causes of the human genetic disease known as ATR-X syndrome. More »

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Research identifies gene that changes the brain’s response to stress

Brains change. They change throughout life, responding to developmental but also environmental cues, like stress. Scientists know of several important proteins that play a role in what brains do with new experience. Now they have identified one, brain-derived neurotrophic factor, which must be present at a certain level to enable the brain’s “adaptive plasticity,” particularly in response to stress. More »

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Imaging studies reveal order in programmed cell death

In order to thrive, the human body orchestrates a mass suicide of about 10 billion potentially dangerous cells a day. New research takes a closer look at programmed cell death — called apoptosis — and finds order in this process, once thought to be an erratically timed, sudden collapse. More »

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Mouse model reveals a cause of ADHD

New research in a mouse model of attention deficit/hyperactivity disorder suggests that the root of the psychiatric disorder might be the over-activity of a protein that regulates the brain’s reward-motivation system. The work suggests a path toward new treatments for symptoms including inattentiveness, over-activity and impulsivity. More »

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