Two Rockefeller University scientists are among 11 winners of the first annual Breakthrough Prize in Life Sciences, an award established by six tech entrepreneurs dedicated to advancing breakthrough research. At $3 million each, the prizes are worth more than twice the amount of the Nobel. They were created to recognize excellence in research aimed at curing intractable diseases and extended human life.
Administered by a new non-profit organization, the Breakthrough Prize in Life Sciences Foundation, the prize is founded by Art Levinson, chairman of the board of Apple and former CEO of Genentech; Sergey Brin, co-founder of Google Inc.; Anne Wojcicki, co-founder of 23andMe; Mark Zuckerberg, founder and CEO of Facebook, and his wife Pricilla Chan; and Yuri Milner, founder of the Russian internet company Mail.ru. More »





















































































































Glands and Ducts Reveals Roles in Homeostasis and Wound Repair
Herpes in STAT1 deficiency
Scale invariance in the dynamics of spontaneous behavior
Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels
Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation
Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcγ receptor engagement
Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation
Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells
Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4
dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
Contingency and statistical laws in replicate microbial closed ecosystems
Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage



Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice



Viral-induced encephalitis initiates distinct and functional CD103+ CD11b+ brain dendritic cell populations within the olfactory bulb

















Entering an Unseen World: A Founding Laboratory and Origins of Modern Cell Biology 1910–1974 tells the story of a Rockefeller laboratory from its humble beginnings as a cancer lab, through the founding of the new science of cell biology, to the ultimate prize for scientific accomplishment.
Both prizes recognize Friedman’s discovery of the leptin pathway and its role in regulating body weight. Together the prizes are worth nearly $750,000; Friedman shares both with Douglas Coleman, emeritus scientist at the Jackson Laboratory.
Researchers led by Rockefeller’s Jesse Ausubel analyzed factors such as global land use and population growth over the last 50 years. Looking at the production index of all crops of the UN’s Food and Agriculture Organization, they found that from 1961 to 2009 land farmed grew by only 12 percent while the index rose about 300 percent.
Darnell will direct all aspects of the NYGC, including its scientific and research activities, and the recruitment and development of a world-class scientific team in genomic research and medicine. Founded in 2010, the NYGC will be one of the largest genomics research facilities in North America, integrating sequencing, bioinformatics and data management.
Rockefeller researchers in Michel Nussenzweig’s Laboratory of Molecular Immunology have found that a newly-discovered class of especially potent antibodies is effective at neutralizing HIV infection in mice for a 60 day period, longer than current antiretroviral drugs which require daily application. The antibodies, which suppressed the virus when used in combination, could one day be given to humans to treat the disease.
New research from Rockefeller University has shown that chemicals in the brain — neuropeptides known as vasopressin and oxytocin — play a role in coordinating mating and reproductive behavior in animals ranging from humans to fish to invertebrates.
Fuchs, head of the Laboratory of Mammalian Cell Biology and Development at Rockefeller University, will be awarded the 2012 Academy Medal for Distinguished Contributions in Biomedical Science for her innovative and imaginative approaches to research in skin biology, its stem cells and its associated human genetic disorders. 


