Beyond epigenetics

Rockefeller University scientists now have moved a step beyond epigenetics in describing how genetically driven activities are carried out. Working with an important molecule, called Ezh2, known to alter histones in the cell nucleus, Sasha Tarakhovsky, Ph.D., and his colleagues have discovered a new type of signaling system in the cytosol, the fluid or jelly-like substance outside of a cell’s nucleus. More »

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For young canaries learning their song, freedom in youth gives way to rules in adulthood

Young canaries can learn atypical songs but recast them into adult canary syntax as they mature, a previously undescribed aspect of vocal prowess in birds. More »

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Two Rockefeller scientists elected to National Academy of Sciences

The National Academy of Sciences announced the election of 72 new members this morning, including two Rockefeller University scientists. More »

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Vaccine developed at Rockefeller University boosts natural killer T cells in patients with cancer

A new vaccine designed at The Rockefeller University boosted a type of fast-responding immune system cell called the natural killer T (NKT) cell in patients with advanced cancer. The study surprised researchers by revealing the ability of these NKT cells to spur other, slower-responding immune cells to go to work. More »

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Jeffrey Friedman, discoverer of leptin, receives Gairdner, Passano awards

Rockefeller University’s Jeffrey M. Friedman, M.D., Ph.D., a molecular geneticist whose discovery of the hormone leptin and its role in regulating body weight has changed our understanding of the causes of human obesity, has received two prestigious awards for this work: the Gairdner Foundation International Award and the Passano Foundation Award. More »

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Rockefeller University researchers are changing the face of addiction treatment

People addicted to heroin, alcohol and other drugs of abuse often fail to stay clean because they won’t go to or won’t stay in treatment. Reporting in the January issue of the Journal of Substance Abuse Treatment, Scott Kellogg, Ph.D., and Mary Jeanne Kreek, M.D., at The Rockefeller University, and colleagues at the New York City Health and Hospitals Corporation (HHC) and at Johns Hopkins University, show that a treatment approach called contingency management improves patients’ motivation to stay in treatment and increases their therapeutic progress. More »

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Mice with defective sperm offer clues to infertility in men

New research in mice by scientists at Rockefeller University and the Population Council sheds light on the causes behind male infertility. More »

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Renowned French neuroscientist Jean-Pierre Changeux receives Rockefeller University’s science writing prize

Jean-Pierre Changeux, Ph.D., one of the boldest thinkers in modern neuroscience, received the Rockefeller University Lewis Thomas Prize for Writing about Science Tues., March 29. More »

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Researchers identify gene that plays major role in age-related blindness disease

Scientists at Rockefeller University, Yale University School of Public Health and the National Eye Institute have identified a gene that confers susceptibility to age-related macular degeneration. More »

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“Blinding” an insect’s sense of smell may be the best repellent

Scientists have found that a single gene is responsible for the sense of smell in fruit flies, malaria mosquitoes, medfly and corn earworm moth. This information may provide a starting point for future designs of pesticides and disease-controlling insect repellents. More »

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Despite causes of lupus proving complex, scientists get a new lead on potential treatment

Scientists at The Rockefeller University have determined that the autoimmune disease lupus results from a combination of genetics that likely varies from person to person, and that a common “gatekeeper” gene called FCR?IIB is critical to the prevention of this devastating disease. More »

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Rockefeller researchers identify new role for key protein that regulates separation of DNA in dividing cells

Rockefeller University scientists have revealed a new function of a key component of the mechanism that cells use to accurately separate chromosomes when they divide. Disruptions in this process can cause diseases such as cancer. More »

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Blocking alcohol’s impact on brain cells

Rockefeller University scientists, in experiments with mice, have discovered a protein that regulates the seizures induced by ethanol withdrawal. The protein, called tissue plasminogen activator, or tPA, is the same factor that dissolves the blood clots that can trigger heart attacks and strokes. More »

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RU mourns loss of Maclyn McCarty, scientist responsible for “pivotal discovery of 20th-century biology”

On Jan. 3, 2005, Rockefeller University President Paul Nurse informed the campus community about the death of Maclyn McCarty, one of the three Rockefeller scientists who in 1944 proved that DNA is the chemical basis for heredity. More »


Novel cellular pathway increases sensitivity of body’s immune detectives

In the Dec. 9 issue of Scientists at Rockefeller University report the discovery of a previously unknown pathway that boosts the ability of helper T cells to “motivate” killer T cells in detecting and attacking dangerous cells. The finding may help scientists to create a more effective immune response against disease and tumor formation. More »

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Many ways to learn one song

Of all the world’s animals, only humans, some kinds of birds and perhaps some porpoises and whales learn the sounds they use to communicate with each other through a process of listening, imitation and practice. For the rest, including nonhuman primates, these sounds develop normally in the absence of external models. Now Rockefeller University scientists have found that zebra finches, songbirds native to Australia, use infant-like strategies to learn their song.
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NYC mayor announces development of bioscience research park at Rockefeller University news conference

New York City Mayor Michael R. Bloomberg, at a news conference hosted by Rockefeller University on Nov. 18, 2004, announced plans to develop the East River Science Park, a bioscience research and development campus, on a city-owned portion of the Bellevue Hospital Center. More »

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Nobel laureate honors deceased mother and other women achievers by awarding a “Nobel Prize for women”

Rockefeller University awarded the first Pearl Meister Greengard Prize to French embryologist Nicole Le Douarin on Wednesday, Oct. 27. More »

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“Crucial evolutionary link”: Molecular sculptor may have molded simple ancient bacterial cells into modern, highly structured cells

A team of researchers led by Rockefeller University’s Michael P. Rout, Ph.D., have discovered a possible crucial evolutionary link between the simple cells that make up bacteria and the more complex cells that comprise animal and plant cells, including those of humans. More »

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Cellular Two Step

Following the often-quoted advice of Yogi Berra — “You can observe a lot by just watching” — Rockefeller University scientists show that nerve cells in the developing brains of humans and other mammals move in a two-part “step” led by a structure within the cell called the centrosome. Once the centrosome, the key organizing point for the cell’s internal skeleton, moves forward, the cell nucleus follows. The Rockefeller scientists produced time-lapse movies that show nerve cell migration in unprecedented clarity and detail. More »

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