A drug called STI-571, now being tested in clinics to treat a rare form of leukemia, selectively blocks a mutant enzyme that causes the disease without harming its molecular cousins. Reporting in the Sept. 15 issue of Science, a team of researchers from the Howard Hughes Medical Institute at The Rockefeller University, the Memorial Sloan-Kettering Cancer Center and the State University of New York at Stony Brook has shown how STI-571 accomplishes this feat, suggesting new avenues for the structure-based design of cancer drugs with reduced side effects. More »
A team of researchers from The Rockefeller University in New York and the Yale University School of Medicine has identified for the first time a candidate pheromone receptor gene in humans. The findings, reported in the September issue of Nature Genetics, may shed new light on the molecular basis of social communication between humans. More »
The tuberculosis bacterium requires a specific enzyme to cause persistent infection, a consortium of researchers at Rockefeller University and three other institutions have found. The discovery suggests that targeting the enzyme could improve therapies for TB, which claims more lives each year than any other bacterial infection. More »
Professor Emeritus, Dr. Abraham Pais, died Friday evening in Copenhagen. A theoretical physicist of international renown, Dr. Pais became a member of the faculty in 1963, when the university was still known as The Rockefeller Institute.
Click on the link to read the New York Times article on Dr. Pais. (Registration is required.) More »
Three of New York’s leading research institutions announced the creation of a $160 million collaborative program in basic biological research sparked by a private donor who will contribute half the total investment.
The collaboration among Cornell University, its Weill Medical College, Memorial Sloan-Kettering Cancer Center, and The Rockefeller University will include the joint recruitment of a dozen new faculty members, reflecting the level of investment demanded by the technological demands of science today. More »
The Rockefeller University community dedicated Peggy Rockefeller Plaza at the south end of its campus today in a ceremony that included music from a brass band, remarks from donors Anne and Robert Bass, and a surprise announcement. More »
Jan Breslow, M.D., head of the Laboratory of Biochemical Genetics and Metabolism at The Rockefeller University, has been selected to receive the 2000 Bristol-Myers Squibb Award for Distinguished Achievement in Cardiovascular Research. Breslow is one of seven researchers in various medical research fields to receive the award in 2000. More »
Findings show for the first time that development of smell is similar to other senses.
Scientists have known for 30 years that proper development of the area of the brain responsible for processing visual signals depends on stimulation from the environment. In other words, the brain must “use it or lose it.” Now researchers fromThe Rockefeller University have shown a similar paradigm in the development of the brain’s wiring for odor detection in mice. More »
New York, NY–Three neighboring New York City medical institutions–The Rockefeller University, NewYork-Presbyterian Hospital, and Weill Medical College of Cornell University–have jointly established the Center for the Study of Hepatitis C, the first major center in the Northeast region devoted specifically to the disease. Renowned virologist Charles M. Rice, Ph.D., who recently made the first infectious clone of the virus, will join The Rockefeller University faculty and serve as both scientific and executive director of the multi-institutional center. More »
Professor Roderick MacKinnon, head of the Laboratory of Molecular Neurobiology and Biophysics and an investigator at the Howard Hughes Medical Institute, was elected to membership in the U.S. National Academy of Sciences (NAS) at the Academy’s 137th meeting on Tues., May 2. MacKinnon studies the functional and structural architecture of ion channel proteins, molecules that govern the electrical potential of membranes throughout nature, thereby generating nerve impulses and controlling muscle contraction, cardiac rhythm and hormone secretion. More »
Penicillin resistance of the bacterium that causes pneumonia, the pneumococcus, is a growing global health problem. Although S. pneumoniae was once considered to be routinely susceptible to penicillin, since the mid-1980s the incidence of resistance of this organism to penicillin and other antimicrobial agents has been increasing in the United States and throughout the world. Now, researchers at The Rockefeller University, reporting in the April 25 issue of the Proceedings of the National Academy of Sciences, show that resistance can be stopped by inactivating a pair of genes responsible for producing molecules called branched muropeptides, the availability of which appears to be essential for the bacterium to survive in the presence of penicillin. The finding suggests that the branched peptides may be a new drug target for fighting penicillin-resistant bacteria. More »
Rockefeller researchers are using genechip technology, a powerful tool for analyzing the expression patterns of thousands of genes at a time. Researchers in the Friedman lab have identified a number of genes that are specifically regulated by the hormone leptin. More »
Researchers at the National Institutes of Health and Rockefeller University have found that a gene known for repairing breaks in the double strands of DNA also acts as a “caretaker” that prevents chromosome segments from rearranging. Recognizing this additional role for the gene, called Ku80, could increase ways of targeting some tumors that develop when the gene is mutated. More »
Researchers from The Rockefeller University and the University of Alberta in Canada have obtained the first comprehensive inventory of the protein components of the nuclear pore complex (NPC), an essential cellular structure that regulates transport between the nucleus and the cytoplasm. More »
Science Outreach student Eugene Simuni was awarded a $25,000 scholarship for his fifth-place win in the Intel Science Talent Search. A senior at Midwood High School, Simuni was mentored by Ethan Marin, of the Sakmar lab. His project explored protein transmission of visual signals to the brain. Simuni was also chosen by his fellow finalists to receive the Glenn T. Seaborg Award for his commitment to scientific cooperation and communication. More »
Bard College and The Rockefeller University have established a new, ongoing collaborative program in science education, Rockefeller President Arnold Levine and Bard President Leon Botstein announced today. More »
With the completion of the Human Genome Project (HGP) in sight, a group of New York City scientists are undertaking a strategic pilot study to turn that knowledge into promising drug targets as quickly as possible. More »
Protein may play a key role in nervous system function Rockefeller University researchers have identified a protein that is responsible for regulating RNA splicing in nerve cells, a process essential for the development and operation of complex nervous systems, such as those found in mammals, including humans. The protein, called Nova-1, is the first splicing factor specific to one kind of tissue to be found in mammals. More »
Valentine’s Day cards usually depict Cupid’s dart as the messenger of love. New scientific research, however, shows that a key messenger molecule, rather than Cupid’s dart, is responsible for female sexual receptivity–at least in rats and mice. More »
Rockefeller University biochemist Robert Roeder, Ph.D., received the Louisa Gross Horwitz Prize from Columbia University on Thursday, Feb. 3. The prize, which Roeder shares with Robert Tjian, Ph.D., of the Howard Hughes Medical Institute at the University of California at Berkeley and Pierre Chambon, M.D., of the Université Louis Pasteur and the College de France, honors scientists for “outstanding basic research in biology or biochemistry.” More »