Glands and Ducts Reveals Roles in Homeostasis and Wound Repair
Herpes in STAT1 deficiency
Scale invariance in the dynamics of spontaneous behavior
Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels
Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation
Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcγ receptor engagement
Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation
Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells
Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4
dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
Contingency and statistical laws in replicate microbial closed ecosystems
Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage
Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice
Viral-induced encephalitis initiates distinct and functional CD103+ CD11b+ brain dendritic cell populations within the olfactory bulb
Protein may play a key role in nervous system function Rockefeller University researchers have identified a protein that is responsible for regulating RNA splicing in nerve cells, a process essential for the development and operation of complex nervous systems, such as those found in mammals, including humans. The protein, called Nova-1, is the first splicing factor specific to one kind of tissue to be found in mammals. More »
Rockefeller University researchers identify protein that regulates RNA in nerve tissue
Tags: gene regulation, RNA, Robert B. Darnell
Sexual behavior pathways in the brain identified
Valentine’s Day cards usually depict Cupid’s dart as the messenger of love. New scientific research, however, shows that a key messenger molecule, rather than Cupid’s dart, is responsible for female sexual receptivity–at least in rats and mice. More »
Tags: DARPP-32, Paul Greengard, sex
Rockefeller Receives Horwitz Prize for Pioneering Work on How Genes are Turned On and Off
Rockefeller University biochemist Robert Roeder, Ph.D., received the Louisa Gross Horwitz Prize from Columbia University on Thursday, Feb. 3. The prize, which Roeder shares with Robert Tjian, Ph.D., of the Howard Hughes Medical Institute at the University of California at Berkeley and Pierre Chambon, M.D., of the Université Louis Pasteur and the College de France, honors scientists for “outstanding basic research in biology or biochemistry.” More »
Four Rockefeller Science Outreach students are finalists in Intel Science Talent Search
Four out of the 10 Science Outreach students who reached the semifinalist stage in the Intel Science Talent Search, have been named finalists: Evan Fink, Adam Kahn, Chrisann Kyi and Eugene Simuni. Only 40 finalists are named each year. In March the finalists will travel to Washington, D.C., to participate in a week-long competition. Ten winners will be announced at a black-tie dinner on Mon., Mar. 13, and will receive scholarships ranging from $20,000 to $100,000. The remaining 30 finalists will each receive a $5,000 scholarship. More »
Understanding Drive: Rockefeller researchers uncover the molecular mechanisms of sexual motivation
For most people, sex is a complicated topic. A new book by RU Professor Donald Pfaff, however, is based on the idea that the primitive, biological side of sex is explainable–at least from a scientific point of view. Pfaff’s lab researches the neurobiological and molecular aspects of sexual motivation. In Drive (MIT Press), he shows that the biological basis for sex drive–one of the most primitive human instincts–is largely explained by mechanisms uncovered in animal brains that have not changed in millions of years of evolution. More »
Tags: Donald W. Pfaff, sex
Rockefeller and Aaron Diamond researcher Douglas Nixon receives Elizabeth Glaser Scientist Award
Douglas F. Nixon, M.D., Ph.D., a scientist at the Aaron Diamond AIDS Research Center (ADARC) at Rockefeller University, today was named a co-winner of the Elizabeth Glaser Scientist Award. The award is given annually by the Elizabeth Glaser Pediatric AIDS Foundation to top scientists from the international research community “on the basis of their knowledge, innovation and dedication.” More »
Rockefeller researchers show testosterone reduces level of Alzheimer’s proteins
Testosterone supplementation in elderly men may be protective in the treatment of Alzheimer’s disease, according to the results of a new study reported by researchers at Rockefeller University. Findings from epidemiological studies have indicated that estrogen-replacement therapy in postmenopausal women may protect against the development of the disease in a similar way. The research is reported in the Feb. 1 issue of the Proceedings of the National Academy of Science. More »
Ten Science Outreach students reach semifinals of Intel Science Talent Search
Ten out of the 60 high school students who participated in RU’s Science Outreach Program have been named semifinalists in the Intel Science Talent Search (formerly the Westinghouse Science Talent Search). This program, now in its 59th year, is one of the most prestigious science awards for high school students in the country. More than 70 percent of the former finalists have gone on to earn Ph.D.s or M.D.s; five have won Nobel Prizes. More »
Upcoming Symposium on Modeling Life Processes on Tuesday, January 11
Joseph Bonner | 212-327-8998 More »
Rockefeller University researchers shed light on brain disorder
A rare but devastating neurological disorder may be caused partly by immune-system cells that are spurred into action against tumors elsewhere in the body and eventually attack the brain, Rockefeller University researchers report. The scientists also found that the neurological damage from these cells, called cytotoxic T lymphocytes (CTLs), might be lessened by giving patients an immunosupressant drug. More »
Tags: CTLs, PCD, Robert B. Darnell
Rockefeller University researchers find molecule that controls the balance between bone creation and bone destruction
Researchers at The Howard Hughes Medical Institute at The Rockefeller University have identified a novel molecular mechanism by which a molecule called TRANCE controls the balance between bone formation and bone destruction. The research, published in the Dec. 22 issue of the journal Molecular Cell, provides long-sought-after answers to questions about bone metabolism and has important implications in the treatment of bone diseases such as osteoporosis and rheumatoid arthritis. More »
Tags: bone, TRANCE, Yongwon Choi
RU researchers find that waking experiences influence the brain’s gene expression during REM sleep
Mammals spend a large portion of their lives sleeping. In addition to allowing the body to rest, sleep seems to play a role in the consolidation of daytime memories. A number of scientific observations have supported the idea that the brain is reactivated during sleep to process sensorimotor information, but how the brain did this remained unknown. In a recent paper in Learning & Memory, a team of Rockefeller scientists show that the expression of a gene linked to the modification of neuronal connections went up during the deepest phase of sleep that follows an enriched waking experience. The team suggests that this could provide a mechanism by which sleep contributes to the consolidation of memories of daytime events. More »
Tags: Sidarta Ribeiro, sleep, ZENK
Nobel Laureate Blobel to Give First Medicine Prize Lecture Live Online
The first live Webcasts of the Nobel Prize lectures will take place on Wed., Dec. 8, 1999. This year’s laureate in Physiology or Medicine, Günter Blobel, M.D., Ph.D., of The Rockefeller University, will present his lecture, “Protein Targeting.” More »
Tags: Günter Blobel, nobel prize
Rockefeller University Cell Biologist, Günter Blobel, Wins 1999 Nobel Prize in Medicine
Rockefeller University cell biologist Günter Blobel, M.D., Ph.D., was awarded the 1999 Nobel Prize in Physiology or Medicine today. Blobel, the John D. Rockefeller Jr. Professor at The Rockefeller University and a Howard Hughes Medical Institute investigator, heads the Laboratory of Cell Biology. More »
Tags: Günter Blobel, nobel prize
Rockefeller Researcher Roderick MacKinnon Receives 1999 Lasker Award
Rockefeller University Professor Roderick MacKinnon, M.D., has been named a recipient of the 1999 Albert Lasker Basic Medical Research Award, the nation’s most distinguished honor for outstanding contributions to basic and clinical medical research. More »
No Viral Rebound After Stopping Drugs: An Anomalous Group of HIV Patients
An unusual group of HIV-infected patients who stopped taking antiviral drugs yet continued to suppress HIV replication may have somehow boosted their immune response against the virus by temporary therapy interruptions, researchers from the Aaron Diamond AIDS Research Center at Rockefeller University report. Although scientists strongly advise against halting drug therapy–because the virus usually comes surging back–this observation suggests that some HIV-infected people can suppress the virus without drugs if they have strong immune responses. More »
Tags: Douglas F. Nixon, HIV, viral rebound
Rockefeller and Aaron Diamond Researchers Say Resistance to HIV Drugs May Be Higher Than Previously Thought
A study of patients infected with the AIDS virus revealed that about one in six was carrying a strain that is resistant to at least one of the drugs targeting HIV, researchers report from the Aaron Diamond AIDS Research Center, an affiliate of The Rockefeller University. Lead author Daniel Boden, M.D., and 11 colleagues report the research as the cover story in the Sept. 22-29 issue of the Journal of the American Medical Association. The authors suggest that further research should try to establish whether AIDS therapy structured around HIV-resistance testing would be more effective than current methods. More »
Rockefeller Researchers Produce 3-D Picture of DNA-reading Molecular Machine
Researchers at The Rockefeller University have determined the first three-dimensional structure of the cellular RNA polymerase (RNAP), a molecular machine that activates individual genes by transcribing, or reading out, the instructions encoded in their DNA. The structure, published in the Sept. 17 issue of the journal Cell, provides scientists with a model for understanding the RNAPs of higher organisms, including humans. More »
Tags: RNAP, Seth Darst
Researchers Propose New Theory to Explain How Visual Pigments are “Tuned”
Scientists from the Howard Hughes Medical Institute (HHMI) at The Rockefeller University and from the University of California-Berkeley have proposed a new theory on how the human eye perceives colors. Using techniques of molecular biology and spectroscopy, the research, reported in the August issue of Trends in Biochemical Sciences, changes the way scientists have thought about color vision for nearly 20 years. More »
Tags: pigment, Thomas P. Sakmar
Rockefeller University Luncheon Honors Science Outreach Program, Promotes Siemens Westinghouse Competition
The Rockefeller University and the Siemens Foundation will sponsor a luncheon on Wednesday, August 18, to honor Rockefeller’s Science Outreach Program for high school students and teachers and to promote the Siemens Westinghouse Science and Technology Competition. Sponsored by The Siemens Foundation, this newly founded national science competition aims to “recognize talent early on, fostering individual growth for those students willing to challenge themselves through the development of independent research projects.” More »
