First Hepatitis-C Center in Northeast Region Established By Rockefeller University, New York-Presbyterian, and Weill Cornell

New York, NY–Three neighboring New York City medical institutions–The Rockefeller University, NewYork-Presbyterian Hospital, and Weill Medical College of Cornell University–have jointly established the Center for the Study of Hepatitis C, the first major center in the Northeast region devoted specifically to the disease. Renowned virologist Charles M. Rice, Ph.D., who recently made the first infectious clone of the virus, will join The Rockefeller University faculty and serve as both scientific and executive director of the multi-institutional center. More »

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Roderick MacKinnon elected to U.S. National Academy of Sciences

Professor Roderick MacKinnon, head of the Laboratory of Molecular Neurobiology and Biophysics and an investigator at the Howard Hughes Medical Institute, was elected to membership in the U.S. National Academy of Sciences (NAS) at the Academy’s 137th meeting on Tues., May 2. MacKinnon studies the functional and structural architecture of ion channel proteins, molecules that govern the electrical potential of membranes throughout nature, thereby generating nerve impulses and controlling muscle contraction, cardiac rhythm and hormone secretion. More »

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Rockefeller Researchers Identify Novel Penicillin-resistance Gene in Pneumonia Bacteria

Penicillin resistance of the bacterium that causes pneumonia, the pneumococcus, is a growing global health problem. Although S. pneumoniae was once considered to be routinely susceptible to penicillin, since the mid-1980s the incidence of resistance of this organism to penicillin and other antimicrobial agents has been increasing in the United States and throughout the world. Now, researchers at The Rockefeller University, reporting in the April 25 issue of the Proceedings of the National Academy of Sciences, show that resistance can be stopped by inactivating a pair of genes responsible for producing molecules called branched muropeptides, the availability of which appears to be essential for the bacterium to survive in the presence of penicillin. The finding suggests that the branched peptides may be a new drug target for fighting penicillin-resistant bacteria. More »

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Chipping Away at Leptin’s Effects

Rockefeller researchers are using genechip technology, a powerful tool for analyzing the expression patterns of thousands of genes at a time. Researchers in the Friedman lab have identified a number of genes that are specifically regulated by the hormone leptin. More »

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NIH And Rockefeller Researchers Find That Gene Acts As “Caretaker” To Genome

Researchers at the National Institutes of Health and Rockefeller University have found that a gene known for repairing breaks in the double strands of DNA also acts as a “caretaker” that prevents chromosome segments from rearranging. Recognizing this additional role for the gene, called Ku80, could increase ways of targeting some tumors that develop when the gene is mutated. More »

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Rockefeller researchers characterize yeast nuclear pore complex

Researchers from The Rockefeller University and the University of Alberta in Canada have obtained the first comprehensive inventory of the protein components of the nuclear pore complex (NPC), an essential cellular structure that regulates transport between the nucleus and the cytoplasm. More »

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Science Outreach H.S. student in top 10 of Intel Science Talent Search

Science Outreach student Eugene Simuni was awarded a $25,000 scholarship for his fifth-place win in the Intel Science Talent Search. A senior at Midwood High School, Simuni was mentored by Ethan Marin, of the Sakmar lab. His project explored protein transmission of visual signals to the brain. Simuni was also chosen by his fellow finalists to receive the Glenn T. Seaborg Award for his commitment to scientific cooperation and communication. More »

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Bard College And Rockefeller University Establish New Collaborative Programs In Science Education

Bard College and The Rockefeller University have established a new, ongoing collaborative program in science education, Rockefeller President Arnold Levine and Bard President Leon Botstein announced today. More »

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NYC pilot study pushes Human Genome Project toward cures for disease

With the completion of the Human Genome Project (HGP) in sight, a group of New York City scientists are undertaking a strategic pilot study to turn that knowledge into promising drug targets as quickly as possible. More »

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Rockefeller University researchers identify protein that regulates RNA in nerve tissue

Protein may play a key role in nervous system function Rockefeller University researchers have identified a protein that is responsible for regulating RNA splicing in nerve cells, a process essential for the development and operation of complex nervous systems, such as those found in mammals, including humans. The protein, called Nova-1, is the first splicing factor specific to one kind of tissue to be found in mammals. More »

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Sexual behavior pathways in the brain identified

Valentine’s Day cards usually depict Cupid’s dart as the messenger of love. New scientific research, however, shows that a key messenger molecule, rather than Cupid’s dart, is responsible for female sexual receptivity–at least in rats and mice. More »

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Rockefeller Receives Horwitz Prize for Pioneering Work on How Genes are Turned On and Off

Rockefeller University biochemist Robert Roeder, Ph.D., received the Louisa Gross Horwitz Prize from Columbia University on Thursday, Feb. 3. The prize, which Roeder shares with Robert Tjian, Ph.D., of the Howard Hughes Medical Institute at the University of California at Berkeley and Pierre Chambon, M.D., of the Université Louis Pasteur and the College de France, honors scientists for “outstanding basic research in biology or biochemistry.” More »

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Four Rockefeller Science Outreach students are finalists in Intel Science Talent Search

Four out of the 10 Science Outreach students who reached the semifinalist stage in the Intel Science Talent Search, have been named finalists: Evan Fink, Adam Kahn, Chrisann Kyi and Eugene Simuni. Only 40 finalists are named each year. In March the finalists will travel to Washington, D.C., to participate in a week-long competition. Ten winners will be announced at a black-tie dinner on Mon., Mar. 13, and will receive scholarships ranging from $20,000 to $100,000. The remaining 30 finalists will each receive a $5,000 scholarship. More »

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Understanding Drive: Rockefeller researchers uncover the molecular mechanisms of sexual motivation

For most people, sex is a complicated topic. A new book by RU Professor Donald Pfaff, however, is based on the idea that the primitive, biological side of sex is explainable–at least from a scientific point of view. Pfaff’s lab researches the neurobiological and molecular aspects of sexual motivation. In Drive (MIT Press), he shows that the biological basis for sex drive–one of the most primitive human instincts–is largely explained by mechanisms uncovered in animal brains that have not changed in millions of years of evolution. More »

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Rockefeller and Aaron Diamond researcher Douglas Nixon receives Elizabeth Glaser Scientist Award

Douglas F. Nixon, M.D., Ph.D., a scientist at the Aaron Diamond AIDS Research Center (ADARC) at Rockefeller University, today was named a co-winner of the Elizabeth Glaser Scientist Award. The award is given annually by the Elizabeth Glaser Pediatric AIDS Foundation to top scientists from the international research community “on the basis of their knowledge, innovation and dedication.” More »

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Rockefeller researchers show testosterone reduces level of Alzheimer’s proteins

Testosterone supplementation in elderly men may be protective in the treatment of Alzheimer’s disease, according to the results of a new study reported by researchers at Rockefeller University. Findings from epidemiological studies have indicated that estrogen-replacement therapy in postmenopausal women may protect against the development of the disease in a similar way. The research is reported in the Feb. 1 issue of the Proceedings of the National Academy of Science. More »

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Ten Science Outreach students reach semifinals of Intel Science Talent Search

Ten out of the 60 high school students who participated in RU’s Science Outreach Program have been named semifinalists in the Intel Science Talent Search (formerly the Westinghouse Science Talent Search). This program, now in its 59th year, is one of the most prestigious science awards for high school students in the country. More than 70 percent of the former finalists have gone on to earn Ph.D.s or M.D.s; five have won Nobel Prizes. More »

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Upcoming Symposium on Modeling Life Processes on Tuesday, January 11

Joseph Bonner | 212-327-8998 More »

Rockefeller University researchers shed light on brain disorder

A rare but devastating neurological disorder may be caused partly by immune-system cells that are spurred into action against tumors elsewhere in the body and eventually attack the brain, Rockefeller University researchers report. The scientists also found that the neurological damage from these cells, called cytotoxic T lymphocytes (CTLs), might be lessened by giving patients an immunosupressant drug. More »

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Rockefeller University researchers find molecule that controls the balance between bone creation and bone destruction

Researchers at The Howard Hughes Medical Institute at The Rockefeller University have identified a novel molecular mechanism by which a molecule called TRANCE controls the balance between bone formation and bone destruction. The research, published in the Dec. 22 issue of the journal Molecular Cell, provides long-sought-after answers to questions about bone metabolism and has important implications in the treatment of bone diseases such as osteoporosis and rheumatoid arthritis. More »

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