Researchers Identify an Enzyme That Regulates the Action of Chronic Cocaine

Scientists have found that an enzyme called Cdk5 regulates the action of chronic cocaine in the brain. In a paper published in the March Nature, members of Paul Greengard’s Laboratory of Molecular and Cellular Neuroscience and colleagues at other institutions identify Cdk5’s role in the long-term changes associated with cocaine addiction. By combining behavioral and biochemical studies, they found that Cdk5 (which stands for cyclin-dependent kinase 5) is a key player in a series of biochemical events that occur in certain brain cells with exposure to chronic cocaine. More »

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Rockefeller University President Arnold Levine Receives First Albany Medical Center Prize

Arnold J. Levine, Ph.D., president of The Rockefeller University, is the first recipient of the Albany Medical Center Prize in Medicine and Biomedical Research. Levine is recognized for his discovery of the p53 tumor suppressor protein, one of the body’s most important defenses against many forms of cancer. More »

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Many Immune Cells Are Fine-tuned to Prevent “Friendly Fire”

About one-quarter of the body’s antibodies are produced by immune cells that have had their genetic code revised during a halt in their development, scientists at Rockefeller University and three other institutions have found. The study is the first to show that this phenomenon, called “receptor editing,” plays a major role in the creation of the body’s huge antibody array. More »

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Rockefeller and Aaron Diamond Researcher David D. Ho Receives Presidential Citizens Medal

Rockefeller University Professor David D. Ho, M.D., scientific director of the Aaron Diamond AIDS Research Center (ADARC), will receive the Presidential Citizens Medal from President Clinton today in a ceremony at the White House. Ho is one of 28 recipients being recognized for “remarkable service and accomplishments” in a variety of areas. More »

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Researchers Identify Key to Genetic Replication in Hepatitis C Virus

Researchers at Rockefeller University and Washington University School of Medicine in St. Louis have identified mutations in a protein of certain strains of hepatitis C virus (HCV) that allow these strains to replicate more vigorously in human cell culture. The finding allows scientists to improve an essential tool for studying the virus and suggests a starting point for the design of effective vaccines. More »

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Researchers find how leprosy bacterium selects and attacks nerves

Researchers at Rockefeller University who study the bacterium that causes leprosy say they have identified a component on the microbe’s surface that allows it to specifically select and attack the peripheral nerves. The finding clarifies how the bacterium, Mycobacterium leprae (M. leprae) precisely seeks out peripheral nerves, and it sheds light on the early stages of nerve damage in other neurodegenerative diseases such as Guillain-Barre syndrome and multiple sclerosis. More »

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Researchers Identify Molecule That Senses Osmotic Pressure in Vertebrates

Researchers at the Howard Hughes Medical Institute and Rockefeller University have identified a molecule in vertebrates that senses osmotic pressure-the measure of saltiness essential for living cells-and may provide an inroad into understanding inner ear function and the sense of touch. More »

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Rockefeller University Computational Biologist Receives Presidential Early Career Award

Theresa Gaasterland, Ph.D., a computational biologist at The Rockefeller University, was one of 20 National Science Foundation-supported researchers named by President Clinton as recipients of the fifth annual Presidential Early Career Awards for Scientists and Engineers (PECASE), the highest honor bestowed by the United States government on young professionals at the outset of their independent research careers. The awards were presented yesterday at the White House Old Executive Office Building by the president’s science advisor, Neal Lane. More »

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Rockefeller University Neurobiologist Paul Greengard wins 2000 Nobel Prize in Medicine, Shares Award with Arvid Carlsson and Eric Kandel

Second Consecutive Medicine Prize Awarded to a Rockefeller University Scientist

Paul Greengard, Ph.D., Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience at The Rockefeller University, has won the 2000 Nobel Prize in Physiology or Medicine for his discovery of how dopamine and a number of other transmitters in the brain exert their action in the nervous system. Last year’s Nobel Prize in Medicine was awarded to Rockefeller University’s G¸nter Blobel, M.D., Ph.D., John D. Rockefeller Jr. Professor and an investigator of the Howard Hughes Medical Institute. More »

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Five New York City Research Institutions Collaborate to Study 3-D Structures of Proteins

The National Institute of General Medical Sciences (NIGMS), part of the U.S. government’s National Institutes of Health, awarded the New York Structural Genomics Research Consortium (NYSGRC) $4.5 million to develop high-speed methods to decipher the three-dimensional structures of proteins. The award will fund the first year of a five year pilot program launched by NIGMS called the Protein Structure Initiative More »

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Scientists Discover Why Experimental Leukemia Drug, STI-571, is Effective

A drug called STI-571, now being tested in clinics to treat a rare form of leukemia, selectively blocks a mutant enzyme that causes the disease without harming its molecular cousins. Reporting in the Sept. 15 issue of Science, a team of researchers from the Howard Hughes Medical Institute at The Rockefeller University, the Memorial Sloan-Kettering Cancer Center and the State University of New York at Stony Brook has shown how STI-571 accomplishes this feat, suggesting new avenues for the structure-based design of cancer drugs with reduced side effects. More »

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Researchers Identify Candidate Human Pheromone Receptor Gene

A team of researchers from The Rockefeller University in New York and the Yale University School of Medicine has identified for the first time a candidate pheromone receptor gene in humans. The findings, reported in the September issue of Nature Genetics, may shed new light on the molecular basis of social communication between humans. More »

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Researchers Find Key to Tuberculosis Persistence in the Body

The tuberculosis bacterium requires a specific enzyme to cause persistent infection, a consortium of researchers at Rockefeller University and three other institutions have found. The discovery suggests that targeting the enzyme could improve therapies for TB, which claims more lives each year than any other bacterial infection. More »

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Rockefeller University Professor Emeritus, Dr. Abraham Pais, Dies at 82

Professor Emeritus, Dr. Abraham Pais, died Friday evening in Copenhagen. A theoretical physicist of international renown, Dr. Pais became a member of the faculty in 1963, when the university was still known as The Rockefeller Institute.

Click on the link to read the New York Times article on Dr. Pais. (Registration is required.) More »

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Three Leading New York Institutions Announce $160 Million Joint Investment in Biological Research

Three of New York’s leading research institutions announced the creation of a $160 million collaborative program in basic biological research sparked by a private donor who will contribute half the total investment.

The collaboration among Cornell University, its Weill Medical College, Memorial Sloan-Kettering Cancer Center, and The Rockefeller University will include the joint recruitment of a dozen new faculty members, reflecting the level of investment demanded by the technological demands of science today. More »

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Rockefeller University Dedicates Peggy Rockefeller Plaza

The Rockefeller University community dedicated Peggy Rockefeller Plaza at the south end of its campus today in a ceremony that included music from a brass band, remarks from donors Anne and Robert Bass, and a surprise announcement. More »

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Rockefeller Researcher Jan Breslow Receives Bristol-Myers Squibb Award For Distinguished Achievement In Cardiovascular Research

Jan Breslow, M.D., head of the Laboratory of Biochemical Genetics and Metabolism at The Rockefeller University, has been selected to receive the 2000 Bristol-Myers Squibb Award for Distinguished Achievement in Cardiovascular Research. Breslow is one of seven researchers in various medical research fields to receive the award in 2000. More »

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Rockefeller Researchers Show Brain Wiring For Detecting Odors May Depend On Experience

Findings show for the first time that development of smell is similar to other senses.

Scientists have known for 30 years that proper development of the area of the brain responsible for processing visual signals depends on stimulation from the environment. In other words, the brain must “use it or lose it.” Now researchers fromThe Rockefeller University have shown a similar paradigm in the development of the brain’s wiring for odor detection in mice. More »

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First Hepatitis-C Center in Northeast Region Established By Rockefeller University, New York-Presbyterian, and Weill Cornell

New York, NY–Three neighboring New York City medical institutions–The Rockefeller University, NewYork-Presbyterian Hospital, and Weill Medical College of Cornell University–have jointly established the Center for the Study of Hepatitis C, the first major center in the Northeast region devoted specifically to the disease. Renowned virologist Charles M. Rice, Ph.D., who recently made the first infectious clone of the virus, will join The Rockefeller University faculty and serve as both scientific and executive director of the multi-institutional center. More »

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Roderick MacKinnon elected to U.S. National Academy of Sciences

Professor Roderick MacKinnon, head of the Laboratory of Molecular Neurobiology and Biophysics and an investigator at the Howard Hughes Medical Institute, was elected to membership in the U.S. National Academy of Sciences (NAS) at the Academy’s 137th meeting on Tues., May 2. MacKinnon studies the functional and structural architecture of ion channel proteins, molecules that govern the electrical potential of membranes throughout nature, thereby generating nerve impulses and controlling muscle contraction, cardiac rhythm and hormone secretion. More »

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