Friedman, Kuriyan and Steinman elected to National Academy of Sciences

The National Academy of Sciences announced the election of 72 new members this morning. Among these are three members of The Rockefeller University faculty. More »

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Diabetes Researchers Find that a Regulator of Insulin Also Regulates Cholesterol Levels

Researchers in Markus Stoffel’s laboratory of Metabolic Diseases have found that that a transcription factor called TCF1 not only regulates insulin production in the pancreas but also controls the regulation of cholesterol. In a paper published in the April issue of Nature Genetics, Stoffel’s team shows that when TRF1 doesn’t function properly, both diabetes and high cholesterol result. More »

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Rockefeller Researchers Identify Defense System in Plants

Researchers at The Rockefeller University have discovered that an experimental plant may harbor an additional line of defense against drought, once it has left the safety of its seed. The work suggests that a well-known plant hormone delays the growth of newly sprouted plants in order to give them one last chance to monitor their environment for signs of dryness before initiating growth. Furthermore, they have identified a specific protein as a key player in the process. More »

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Researchers Light the Path of Brain’s Feeding Circuit in Mice

A novel technique that uses a virus tagged with a green-glowing jellyfish protein has enabled scientists to visualize the feeding circuit in mice. The method may be useful in studies of other complex circuits in the brain. The findings are reported in the March 30 issue of Science by a team of researchers from The Rockefeller University, the Howard Hughes Medical Institute, Princeton University and the University of California at San Diego. More »

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Researchers Discover Promoter of Nerve Tissue in Frogs

Researchers at The Rockefeller University have discovered that a protein known to be involved in the early development of embryos indirectly leads to the formation of nerve tissue in frogs. The findings, reported in the March 22 issue of Nature, may have applications in such neurodegenerative diseases as Alzheimer’s and Parkinson’s. More »

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Researchers Find Novel Way to Kill Streptococci Bacteria

Researchers at The Rockefeller University have discovered a powerful new way to destroy on contact the bacteria that cause strep throat, flesh-eating disease and a variety of other infections. The technique, which may not cause the bacteria to evolve resistant strains as antibiotics do, also could have applications for many other bacterial diseases. The findings are reported in the March 20 issue of Proceedings of the National Academy of Sciences (Early Edition Issue No. 12). More »

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Researchers Identify an Enzyme That Regulates the Action of Chronic Cocaine

Scientists have found that an enzyme called Cdk5 regulates the action of chronic cocaine in the brain. In a paper published in the March Nature, members of Paul Greengard’s Laboratory of Molecular and Cellular Neuroscience and colleagues at other institutions identify Cdk5’s role in the long-term changes associated with cocaine addiction. By combining behavioral and biochemical studies, they found that Cdk5 (which stands for cyclin-dependent kinase 5) is a key player in a series of biochemical events that occur in certain brain cells with exposure to chronic cocaine. More »

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Rockefeller University President Arnold Levine Receives First Albany Medical Center Prize

Arnold J. Levine, Ph.D., president of The Rockefeller University, is the first recipient of the Albany Medical Center Prize in Medicine and Biomedical Research. Levine is recognized for his discovery of the p53 tumor suppressor protein, one of the body’s most important defenses against many forms of cancer. More »

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Many Immune Cells Are Fine-tuned to Prevent “Friendly Fire”

About one-quarter of the body’s antibodies are produced by immune cells that have had their genetic code revised during a halt in their development, scientists at Rockefeller University and three other institutions have found. The study is the first to show that this phenomenon, called “receptor editing,” plays a major role in the creation of the body’s huge antibody array. More »

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Rockefeller and Aaron Diamond Researcher David D. Ho Receives Presidential Citizens Medal

Rockefeller University Professor David D. Ho, M.D., scientific director of the Aaron Diamond AIDS Research Center (ADARC), will receive the Presidential Citizens Medal from President Clinton today in a ceremony at the White House. Ho is one of 28 recipients being recognized for “remarkable service and accomplishments” in a variety of areas. More »

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Researchers Identify Key to Genetic Replication in Hepatitis C Virus

Researchers at Rockefeller University and Washington University School of Medicine in St. Louis have identified mutations in a protein of certain strains of hepatitis C virus (HCV) that allow these strains to replicate more vigorously in human cell culture. The finding allows scientists to improve an essential tool for studying the virus and suggests a starting point for the design of effective vaccines. More »

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Researchers find how leprosy bacterium selects and attacks nerves

Researchers at Rockefeller University who study the bacterium that causes leprosy say they have identified a component on the microbe’s surface that allows it to specifically select and attack the peripheral nerves. The finding clarifies how the bacterium, Mycobacterium leprae (M. leprae) precisely seeks out peripheral nerves, and it sheds light on the early stages of nerve damage in other neurodegenerative diseases such as Guillain-Barre syndrome and multiple sclerosis. More »

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Researchers Identify Molecule That Senses Osmotic Pressure in Vertebrates

Researchers at the Howard Hughes Medical Institute and Rockefeller University have identified a molecule in vertebrates that senses osmotic pressure-the measure of saltiness essential for living cells-and may provide an inroad into understanding inner ear function and the sense of touch. More »

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Rockefeller University Computational Biologist Receives Presidential Early Career Award

Theresa Gaasterland, Ph.D., a computational biologist at The Rockefeller University, was one of 20 National Science Foundation-supported researchers named by President Clinton as recipients of the fifth annual Presidential Early Career Awards for Scientists and Engineers (PECASE), the highest honor bestowed by the United States government on young professionals at the outset of their independent research careers. The awards were presented yesterday at the White House Old Executive Office Building by the president’s science advisor, Neal Lane. More »

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Rockefeller University Neurobiologist Paul Greengard wins 2000 Nobel Prize in Medicine, Shares Award with Arvid Carlsson and Eric Kandel

Second Consecutive Medicine Prize Awarded to a Rockefeller University Scientist

Paul Greengard, Ph.D., Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience at The Rockefeller University, has won the 2000 Nobel Prize in Physiology or Medicine for his discovery of how dopamine and a number of other transmitters in the brain exert their action in the nervous system. Last year’s Nobel Prize in Medicine was awarded to Rockefeller University’s G¸nter Blobel, M.D., Ph.D., John D. Rockefeller Jr. Professor and an investigator of the Howard Hughes Medical Institute. More »

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Five New York City Research Institutions Collaborate to Study 3-D Structures of Proteins

The National Institute of General Medical Sciences (NIGMS), part of the U.S. government’s National Institutes of Health, awarded the New York Structural Genomics Research Consortium (NYSGRC) $4.5 million to develop high-speed methods to decipher the three-dimensional structures of proteins. The award will fund the first year of a five year pilot program launched by NIGMS called the Protein Structure Initiative More »

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Scientists Discover Why Experimental Leukemia Drug, STI-571, is Effective

A drug called STI-571, now being tested in clinics to treat a rare form of leukemia, selectively blocks a mutant enzyme that causes the disease without harming its molecular cousins. Reporting in the Sept. 15 issue of Science, a team of researchers from the Howard Hughes Medical Institute at The Rockefeller University, the Memorial Sloan-Kettering Cancer Center and the State University of New York at Stony Brook has shown how STI-571 accomplishes this feat, suggesting new avenues for the structure-based design of cancer drugs with reduced side effects. More »

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Researchers Identify Candidate Human Pheromone Receptor Gene

A team of researchers from The Rockefeller University in New York and the Yale University School of Medicine has identified for the first time a candidate pheromone receptor gene in humans. The findings, reported in the September issue of Nature Genetics, may shed new light on the molecular basis of social communication between humans. More »

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Researchers Find Key to Tuberculosis Persistence in the Body

The tuberculosis bacterium requires a specific enzyme to cause persistent infection, a consortium of researchers at Rockefeller University and three other institutions have found. The discovery suggests that targeting the enzyme could improve therapies for TB, which claims more lives each year than any other bacterial infection. More »

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Rockefeller University Professor Emeritus, Dr. Abraham Pais, Dies at 82

Professor Emeritus, Dr. Abraham Pais, died Friday evening in Copenhagen. A theoretical physicist of international renown, Dr. Pais became a member of the faculty in 1963, when the university was still known as The Rockefeller Institute.

Click on the link to read the New York Times article on Dr. Pais. (Registration is required.) More »

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