Rockefeller University researchers find molecule that controls the balance between bone creation and bone destruction

Researchers at The Howard Hughes Medical Institute at The Rockefeller University have identified a novel molecular mechanism by which a molecule called TRANCE controls the balance between bone formation and bone destruction. The research, published in the Dec. 22 issue of the journal Molecular Cell, provides long-sought-after answers to questions about bone metabolism and has important implications in the treatment of bone diseases such as osteoporosis and rheumatoid arthritis. More »

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RU researchers find that waking experiences influence the brain’s gene expression during REM sleep

Mammals spend a large portion of their lives sleeping. In addition to allowing the body to rest, sleep seems to play a role in the consolidation of daytime memories. A number of scientific observations have supported the idea that the brain is reactivated during sleep to process sensorimotor information, but how the brain did this remained unknown. In a recent paper in Learning & Memory, a team of Rockefeller scientists show that the expression of a gene linked to the modification of neuronal connections went up during the deepest phase of sleep that follows an enriched waking experience. The team suggests that this could provide a mechanism by which sleep contributes to the consolidation of memories of daytime events. More »

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Nobel Laureate Blobel to Give First Medicine Prize Lecture Live Online

The first live Webcasts of the Nobel Prize lectures will take place on Wed., Dec. 8, 1999. This year’s laureate in Physiology or Medicine, Günter Blobel, M.D., Ph.D., of The Rockefeller University, will present his lecture, “Protein Targeting.” More »

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Rockefeller University Cell Biologist, Günter Blobel, Wins 1999 Nobel Prize in Medicine

Rockefeller University cell biologist Günter Blobel, M.D., Ph.D., was awarded the 1999 Nobel Prize in Physiology or Medicine today. Blobel, the John D. Rockefeller Jr. Professor at The Rockefeller University and a Howard Hughes Medical Institute investigator, heads the Laboratory of Cell Biology. More »

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Rockefeller Researcher Roderick MacKinnon Receives 1999 Lasker Award

Rockefeller University Professor Roderick MacKinnon, M.D., has been named a recipient of the 1999 Albert Lasker Basic Medical Research Award, the nation’s most distinguished honor for outstanding contributions to basic and clinical medical research. More »

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No Viral Rebound After Stopping Drugs: An Anomalous Group of HIV Patients

An unusual group of HIV-infected patients who stopped taking antiviral drugs yet continued to suppress HIV replication may have somehow boosted their immune response against the virus by temporary therapy interruptions, researchers from the Aaron Diamond AIDS Research Center at Rockefeller University report. Although scientists strongly advise against halting drug therapy–because the virus usually comes surging back–this observation suggests that some HIV-infected people can suppress the virus without drugs if they have strong immune responses. More »

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Rockefeller and Aaron Diamond Researchers Say Resistance to HIV Drugs May Be Higher Than Previously Thought

A study of patients infected with the AIDS virus revealed that about one in six was carrying a strain that is resistant to at least one of the drugs targeting HIV, researchers report from the Aaron Diamond AIDS Research Center, an affiliate of The Rockefeller University. Lead author Daniel Boden, M.D., and 11 colleagues report the research as the cover story in the Sept. 22-29 issue of the Journal of the American Medical Association. The authors suggest that further research should try to establish whether AIDS therapy structured around HIV-resistance testing would be more effective than current methods. More »

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Rockefeller Researchers Produce 3-D Picture of DNA-reading Molecular Machine

Researchers at The Rockefeller University have determined the first three-dimensional structure of the cellular RNA polymerase (RNAP), a molecular machine that activates individual genes by transcribing, or reading out, the instructions encoded in their DNA. The structure, published in the Sept. 17 issue of the journal Cell, provides scientists with a model for understanding the RNAPs of higher organisms, including humans. More »

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Researchers Propose New Theory to Explain How Visual Pigments are “Tuned”

Scientists from the Howard Hughes Medical Institute (HHMI) at The Rockefeller University and from the University of California-Berkeley have proposed a new theory on how the human eye perceives colors. Using techniques of molecular biology and spectroscopy, the research, reported in the August issue of Trends in Biochemical Sciences, changes the way scientists have thought about color vision for nearly 20 years. More »

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Rockefeller University Luncheon Honors Science Outreach Program, Promotes Siemens Westinghouse Competition

The Rockefeller University and the Siemens Foundation will sponsor a luncheon on Wednesday, August 18, to honor Rockefeller’s Science Outreach Program for high school students and teachers and to promote the Siemens Westinghouse Science and Technology Competition. Sponsored by The Siemens Foundation, this newly founded national science competition aims to “recognize talent early on, fostering individual growth for those students willing to challenge themselves through the development of independent research projects.” More »

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Rockefeller Scientists Discover a Surprising New Cancer Gene

Scientists at The Rockefeller University have found, for the first time, that the persistent activation of a protein called Stat3 can, by itself, cause normal cells to behave like cancer cells. The research, reported in the August 6 issue of Cell, provides both a scientific surprise and a promising new target in the fight against cancer. Scientists already knew that Stat3 was often activated in various human cancer types, including lymphomas, leukemias, breast cancer and a high percentage of head and neck cancers, but until now no one knew whether persistent Stat3 activation could contribute directly to the development of tumors. More »

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Rockefeller Researchers Inject Cells, Boost Immune System in Humans

A single injection of specialized immune system cells­removed from the bloodstream and exposed to a foreign substance­can trigger a potent immune response in humans that lasts for months, Rockefeller University researchers report. The experiment provides the first conclusive evidence that one dose of these cells, called dendritic cells, can prompt a strong immune response, and it suggests new ways of improving vaccines and protecting against cancer. More »

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Rockefeller and Michigan State Scientists Identify Dangers of Tamoxifen and Recommend Simple Corrective Measures

A team of researchers at The Rockefeller University and Michigan State University has identified a biochemical mechanism that may cause the potentially life-threatening side-effects associated with use of the anti-breast cancer drug tamoxifen, and has recommended steps to reduce the danger. The findings are reported in the June 25 issue of the Journal of Biological Chemistry. More »

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Rockefeller University Researchers Find Large Hole-Forming Protein in Bacteria — A Potential Achilles’ Heel?

Researchers at The Rockefeller University have shown for the first time that a protein called pIV forms a hole in the outer membrane of the bacterium E. coli to allow passage of large molecules. The finding, reported in the May 28 issue of the journal Science, may allow researchers to exploit the bacterium’s Achilles’ heel to better deliver antibiotics. More »

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Rockefeller University Scientists Receive Prestigious Awards for Cancer Research

Arnold J. Levine, Ph.D., newly appointed president of The Rockefeller University, and Robert G. Roeder, Ph.D., professor and head of the Laboratory of Biochemistry and Molecular Biology, have been recognized by the General Motors Cancer Research Foundation for their major contributions to cancer research. More »

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Neurobiologists Show How the Brain Processes Signals from Pheromones

Researchers at The Rockefeller University have shown for the first time in mice how the brain processes signals from pheromones, essential chemicals used by animals to communicate with each other. Reported in the April 16 issue of Cell, the findings provide the first look at the “wiring diagram” of the accessory olfactory system and show that it differs dramatically from the wiring diagram for the main olfactory system, which all mammals, including humans, use to detect smells. More »

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Researchers Shed Light on How Cells Commit Suicide

A team of researchers led by Associate Professor David Cowburn,Ph.D., has determined the three-dimensional structure of a moleculethat regulates programmed cell death, a critical process importantfor many diseases, including cancer, heart disease and autoimmunity.The structure, reported in the March 5 issue of the journal Cell,provides a model for developing compounds to switch cell suicideon or off to treat these diseases. More »

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Researchers Report Emergence of Antibiotic Resistance during Vancomycin Therapy

A team of researchers led by The Rockefeller University’s AlexanderTomasz, Ph.D., have described the case of a 79-year-old patientwhose death in a New York metropolitan area hospital last Marchwas associated with a bloodstream infection caused by a multidrug-resistantstrain of Staphylococcus aureus. The report, publishedin the Feb. 18 issue of the New England Journal of Medicine(NEJM), showed that the bacteria, which had decreased susceptibilityto vancomycin, could be treated effectively with a combinationof antibiotics. More »

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A Little Stress May Have Big Benefits for Health

Rockefeller University researchers have shown that brain hormonesrally immune cells in response to stress. The findings, reportedin the Feb. 2 issue of the Proceedings of the National Academyof Sciences (PNAS), contradict the widely held notion thatall stress is bad for health and provides a basis for understandingthe role of stress in health and disease. More »

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400 High School Students Attack Foreign Invaders!: RU Mirsky Lecture on the Body’s Immune Response

On Monday, December 28, from 10:30 a.m. to 3:00 p.m., one of the leaders in the field of immunology will share his latest research with 400 area high school science students at the 39th Annual Alfred E. Mirsky Christmas Lecture Series on Science, The Rockefeller University, Caspary Hall, 1230 York Avenue (at 66th Street). Student attendance is by ticket only. Press coverage is invited. More »

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