Glands and Ducts Reveals Roles in Homeostasis and Wound Repair
Herpes in STAT1 deficiency
Scale invariance in the dynamics of spontaneous behavior
Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels
Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation
Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcγ receptor engagement
Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation
Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells
Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4
dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
Contingency and statistical laws in replicate microbial closed ecosystems
Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage
Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice
Viral-induced encephalitis initiates distinct and functional CD103+ CD11b+ brain dendritic cell populations within the olfactory bulb
A new approach gives researchers the ability to isolate single antibodies as well as investigate entire families of highly active antibodies against HIV.
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Scientists identify broad and potent HIV antibodies that mimic CD4 binding
Cancer stem cells identified, offering new drug targets
Stem cell researchers at Rockefeller University have identified stem cells of squamous cell skin carcinoma, the second most common cancer in the world, and their molecular signature. The researchers find differences between cancer stem cells and healthy skin stem cells, which provide invaluable diagnostic marker and suggests the possibility to specifically target the root of cancer while leaving normal cells unaffected. More »
Tags: Elaine Fuchs, stem cells
Rockefeller alum Vanessa Ruta named to university’s faculty
Ruta, a neuroscientist interested in understanding how circuits in the brain can be modified by experience, will establish the Laboratory of Neurophysiology and Behavior this fall.
Tags: Vanessa Ruta
23 students receive Ph.D.s at Rockefeller’s 53rd commencement
The Rockefeller University will award doctoral degrees to 23 students at its commencement ceremony today, and in addition, will award honorary doctor of science degrees to two respected scholars: Richard Axel of Columbia University and Linda B. Buck of the Fred Hutchinson Cancer Research Center. More »
Tags: convocation
Scientists create humanized mouse model for hepatitis C
A team of researchers led by scientists in the Laboratory of Virology and Infectious Disease at Rockefeller have, for the first time, recreated a portion of the hepatitis C virus life cycle in a mouse with a functional immune system. The new mouse model will enable scientists to test molecules that block entry of the hepatitis C virus into cells as well as potential vaccine candidates. More »
Tags: Charles M. Rice, hepatitis C
The Great Reversal, an increase in forest density worldwide, is under way
A new study by scientists at Rockefeller University and colleagues in the United States and Finland challenges measurements of carbon storage based on forest area alone. Several national increases of density and/or area signal the Great Reversal is under way in forests globally after centuries of loss and decline. More »
2011 Pearl Meister Greengard Prize to be awarded to McGill University memory researcher
Brenda Milner, a pioneer in the field of cognitive neuroscience whose discoveries revolutionized the understanding of memory, will be awarded the 2011 Pearl Meister Greengard Prize from The Rockefeller University.
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Genes help worms decide where to dine
A recent study by Rockefeller University researchers identifies natural variations in several genes that help determine when and where microscopic C. elegans worms feast. The impact of the gene variants on the worms’ foraging behavior was the most significant in borderline decisions, the researchers says, when the bacteria available to eat were neither scarce nor plentiful. More »
Marc Tessier-Lavigne to receive Sloan-Kettering Medal
Rockefeller University’s President will receive the Memorial Sloan-Kettering Medal for Outstanding Contributions to Biomedical Research at MSKCC’s 2011 Academic Convocation. More »
Jean-Laurent Casanova honored with Belgium’s highest scientific prize
Jean-Laurent Casanova has received the 2011 InBev-Baillet Latour Health Prize, Belgium’s most important scientific prize, for his pioneering work on the identification of genes that predispose for human infectious disease. More »
Michel C. Nussenzweig elected to National Academy of Sciences
Michel C. Nussenzweig, Sherman Fairchild Professor and head of the Laboratory of Molecular Immunology, was elected a member of the National Academy of Sciences at the Academy’s annual meeting today, in recognition of his deep contributions to our understanding of the workings of the innate and adaptive immune systems. More »
Analysis of sperm differentiation reveals new mode of proteasome regulation
The proteasome plays a key role in the differentiation of specialized cells and in maintaining them as they age. The ability to manipulate the proteasome has already been useful in the treatment of multiple myeloma; it could help treat other cancers and degenerative disorders including Parkinson’s and Alzheimer’s as well. New research identifies a key protein, called DmPI31, that regulates the proteasome, which could provide researchers a handle for using it to good medical effect. “Controlled proteolysis is essential for many cell biological functions,” says Hermann Steller, head of the Strang Laboratory of Apoptosis and Cancer Biology. “There had been the impression that the proteasome is just a brute ‘shredder,’ but it doesn’t run at full steam all the time. It’s modulated, and these findings give us new ideas for designing small molecules that regulate proteasome activity.” More »
Tags: DmPI31, Hermann Steller, proteasomes
Anti-inflammatory drugs reduce effectiveness of SSRI antidepressants
Scientists have shown that anti-inflammatory drugs, which include ibuprofen, aspirin and naproxen, reduce the effectiveness of the most widely used class of antidepressant medications, the selective serotonin reuptake inhibitors, or SSRIs, often prescribed for depression and obsessive-compulsive and anxiety disorders. More »
Jesse Ausubel elected to American Academy of Arts and Sciences
Ausubel, a researcher who studies environmental science and technology and industrial evolution, is honored with election to the prestigious independent policy research academy. More »
Polarized microscopy technique shows new details of how proteins are arranged
A key component of the nuclear pore complex — a Y-shaped cluster of proteins that helps determine what gets in and what stays out of a cell’s nucleus — was first photographed and modeled at Rockefeller in 2009. But fundamental questions about how the structures were aligned in relation to the rest of the 30-protein complex remained. Researchers at Rockefeller University have now developed a new technique that uses polarized light microscopy to help answer questions about the proteins’ orientation. More »
Fernando Nottebohm to receive Sackler Prize
Rockefeller University’s Fernando Nottebohm will receive The Mortimer D. Sackler Prize for Distinguished Achievement in Developmental Psychobiology in recognition of his seminal work in songbirds that has led to the discovery of neuronal replacement. More »
‘Big picture’ of how interferon-induced genes launch antiviral defenses revealed
A team of researchers, led by scientists from Rockefeller University, for the first time has carried out a comprehensive, systematic evaluation of the antiviral activity of factors induced by interferon. The findings, published online today in the journal Nature, are a first step toward unraveling how these naturally occurring molecules work to inhibit viruses. More »
Researchers put potent staph killer to the test, hope for new drug treatment
The ever escalating war between evolving bacteria and antibiotics could be taking a promising turn in favor of the humans. Scientists have genetically engineered a powerful killer of one of the most dangerous bacteria, methicillin-resistant Staphylococcus aureus (MRSA). It’s been tested on MRSA in the test tube, on infections in mice and a clinical trial has begun to probe its ability to kill MRSA infected cells from psoriasis lesions in people. Next up, per the recommendation of the FDA, is a test in minipigs. “It’s the start of a new class of drugs,” says the lead researcher, and early signs suggest it’s stronger than anything of its kind currently on the market. More »
Bruce S. McEwen to receive Scolnick Prize for research on brain hormones
Bruce S. McEwen, a pioneer in understanding how hormones affect the brain, will receive the 2011 Edward M. Scolnick Prize in Neuroscience from the McGovern Institute for Brain Research at MIT. McEwen is being honored for research on how hormones affect the brain’s structure, how they shape responses to stress, how they contribute to sexual differences and how they affect our health and well-being. More »
Bullying alters brain chemistry, leads to anxiety
Getting kicked around is no fun for anyone, but researchers are finding that it’s not just the body that’s bruised, but the brain, too. New experiments from Rockefeller show that mice that are repeatedly bullied by by dominant males grow unusually anxious around new company, threatening or not. The behavioral change seems to be in part due to a change in gene expression that increases sensitivity to vasopressin, a hormone involved in a variety of social behaviors. More »
