Study reveals the architecture of the molecular machine that copies DNA

Study reveals the architecture of the molecular machine that copies DNAUntil now, the exact configuration of the replisome, a block of proteins that unzips the DNA helix and creates two duplicate helices, was unknown. After taking the first complete pictures of it, researchers were surprised to find the complex possesses a counterintuitive architecture, raising new questions about its functions. More »

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Researchers examine how a face represents a whole person in the brain

Researchers examine how a face represents a whole person in the brainA face is more than a collection of features; it can represent the complete individual. A new brain imaging study shows that parts of a primate face processing system actually prefer faces with bodies, offering new insight into how faces convey this broader social information. More »

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Discovery of genes involved in inner ear development hints at a way to restore hearing and balance

Discovery of genes involved in inner ear development hints at a way to restore hearing and balanceScientists have identified two genes crucial to the production of delicate sensors, called hair cells, in mammals. These genes, or others in the same pathway, could be promising targets for efforts to treat hearing loss or balance problems, the scientists suggest. More »

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Researchers explore how a cell’s protein-making factories are assembled

Researchers explore how a cell’s protein-making factories are assembledThe intricate dynamics of ribosome assembly, an elaborate and carefully coordinated process that happens continuously inside cells, are not yet fully understood. Using a new technique they devised, researchers have mapped out the proteins involved in the early stages of the construction of a ribosome. More »

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Researchers identify potential new leukemia drug target

Researchers identify potential new leukemia drug targetIn some cases of acute myeloid leukemia, a mutant protein is known to cause dramatic changes in gene expression. Now researchers have identified a second protein with similar function that plays an even broader role in the disease. More »

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Jean-Laurent Casanova elected to the National Academy of Medicine

Jean-Laurent Casanova elected to the National Academy of MedicineWith his election, Casanova, who investigates the genetic underpinnings of unusual vulnerability to specific infectious diseases among young people, receives one of the highest honors within the field of medicine. Seventeen Rockefeller scientists are currently members of the academy of medicine. More »

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Helmsley Trust renews $15 million grant for novel digestive disorders research

Helmsley Trust renews $15 million grant for novel digestive disorders research The funding renewal will support research initiatives within Rockefeller’s interdisciplinary Center for Basic and Translational Research on Disorders of the Digestive System. The center brings together about 20 labs that study a broad range of biological processes related to the digestive system. More »

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New faculty member develops light-based tools to study the brain

Newest addition to Rockefeller faculty studies how cellular metabolism contributes to diseaseAlipasha Vaziri, who was appointed a tenure-track associate professor in September, seeks to capture and manipulate interactions among neurons within the living brain. He uses his background in physics to develop innovative ways of recording neural activity quickly and across large areas, all at single-cell resolution. More »

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Two Rockefeller postdocs recognized by Blavatnik Regional Awards

Two Rockefeller postdocs recognized by Blavatnik Regional Awards

Hani Goodarzi and Ziv Shulman have been named a winner and a finalist, respectively, by the Blavatnik Regional Awards, which honor outstanding postdoctoral scientists in New York, New Jersey, and Connecticut. Goodarzi is a postdoc in Sohail Tavazoie’s lab; Shulman, a former postdoc in Michel Nussenzweig’s lab, has since established his own lab at the Weizmann Institute of Science in Israel.

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Newly described ion channel structure reveals how excited neurons settle down

The long anticipated structure of an ion channel reveals how excited neurons settle downThe channel, Slo2.2, helps restore neurons’ internal electrical state, and so prevents them from firing at too high a frequency for too long, which has the potential to damage the cells. With the new information about Slo2.2’s configuration, researchers can better understand how it accomplishes this. More »

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Finches offer researchers a new tool to study Huntington’s disease

Finches offer researchers a new tool with which to study Huntington’s diseaseThe most common lab animals, rats and mice, can’t tell scientists much about speech disorders. However, a new study shows how songbirds, specifically zebra finches, may be able to aid research on neurodegenerative disorders that affect speech and vocalization. More »

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Researchers probe the physical forces involved in creating the mitotic spindle

Researchers probe the physical forces involved in creating the mitotic spindleScientists have gained new insight into the formation of the spindle, which is the molecular machine that divides up genetic material prior to cell division. Their work focuses on the motor protein, kinesin-5, which helps to organize the spindle’s filaments. More »

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Funding from Kavli Foundation to establish new institute at Rockefeller devoted to neuroscience

The Kavli Foundation and The Rockefeller University today announced the formation of the Kavli Neural Systems Institute (Kavli NSI) at Rockefeller, funded by a $20 million endowment supported equally by Kavli and Rockefeller. The Institute will become part of a network of seven Kavli Institutes carrying out fundamental research in neuroscience, and a broader network of 20 Kavli Institutes dedicated to astrophysics, nanoscience, neuroscience, and theoretical physics. More »

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Study offers insight on how a new class of antidepressants works

Study offers insight on how a new class of antidepressants worksThe experimental drugs target brain cells’ ability to respond to the chemical messenger glutamate, however, it has been unclear how they work. The recent discovery of a molecular amplification system helps explain how the drugs alter signaling in particular neurons to achieve an antidepressant effect. More »

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Helen Hobbs will receive the 2015 Pearl Meister Greengard Prize

Helen Hobbs will receive the 2015 Pearl Meister Greengard PrizeHobbs, of the University of Texas Southwestern Medical Center and the Howard Hughes Medical Institute, is being recognized for her work on the genetic determinants of plasma lipoprotein levels and risk for cardiovascular disease. The prize is intended to honor the extraordinary work of established women scientists and to motivate young women considering careers in the sciences. More »

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Heilbrunn Center announces recipients of its Nurse Scholar Awards

Three nurses at New York state universities have been selected as recipients of the awards, which The Rockefeller University gives annually to support nurses while they pursue independent research. This year’s winners will study sleep disruption associated with asthma in women, the relationship between mothers’ self-perceptions and children’s diet, and how self-perception as a drinker affects smoking. More »

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New findings help explain how molecules are speedily transported into and out of the cell’s nucleus

New findings help explain how molecules are speedily transported into and out of the cell's nucleusThe nuclear pore complex, a gate into and out of the nucleus, is capable of an impressive feat: allowing large molecules to pass through, both selectively and quickly. Researchers have now identified the molecular mechanism that makes this possible. More »

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For worms, positive thinking is the key to finding food

For worms, positive thinking is the key to finding foodA newly described neural circuit in the brain of C. elegans derives precise and simple information from the smell of food, nudging the animal in the direction of the food source. This discovery shows the worm brain may be more sophisticated in processing sensory information than previously realized. More »

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Joel Cohen and Torsten Wiesel receive Golden Goose Awards for research with unexpected benefits

Joel Cohen and Torsten Wiesel receive Golden Goose Awards for research with unexpected benefits

The Golden Goose Award, which honors seemingly obscure federally funded research that has led to major breakthroughs, recognizes Cohen’s development of a map of human population by geographic altitude and Wiesel’s experiments showing cats dots or lights projected on a screen. Cohen’s project has had many applications in fields ranging from microchip manufacturing to human disease, while Wiesel’s discoveries led to a better understanding of the visual system, as well as improved treatment of childhood cataracts.

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New findings shed light on fundamental process of DNA repair

New findings shed light on fundamental process of DNA repairScientists have identified a new component of the molecular machinery a cell uses to repair damaged DNA. The discovery adds important knowledge about a fundamental life process that protects from diseases such as cancer. More »

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