The histone variant H3.3 appears to help keep certain genetic elements called retrotransponsons in place in the genome, preventing potentially harmful mutations in mouse embryonic stem cells, researchers have found. This discovery reveals a basic mechanism for epigenetics, or the control of inherited traits through means other than DNA. More »
Vosshall, who investigates how sensory stimuli are perceived and processed, and Casanova, who studies the genetics of infectious disease susceptibility in children, are among the new members and foreign associates to be inducted into the Academy in 2015. With Vosshall and Casanova’s election, Rockefeller now boasts 36 members or foreign associates of the National Academy of Sciences among its current faculty.
In recognition of her pioneering research on mammalian skin and adult stem cells, Fuchs has received the E.B. Wilson Medal, the highest scientific honor bestowed by the American Society for Cell Biology. The medal will be presented at the society’s annual meeting in California on December 15. More »
Granted by the Robert Koch Foundation, the annual award is one of Germany’s most distinguished scientific prizes and honors extraordinary accomplishments in infectious disease research. It recognizes Rice’s work on understanding the lifecycle of the hepatitis C virus and laying the groundwork for effective therapeutic developments. More »
Does a particular genetic variation translate into a predisposition to an illness, or is it simply a benign rearrangement of genetic code? Drawing up on genomic data from thousands of people, researchers attempted to answer this question by focusing on mutations in two genes associated with a key receptor in blood clotting. More »
In the first results to emerge from HIV patient trials of a new generation of so-called broadly neutralizing antibodies, Rockefeller University researchers have found the experimental therapy can dramatically reduce the amount of virus present in a patient’s blood. The work, reported this week in Nature, brings fresh optimism to the field of HIV immunotherapy and suggests new strategies for fighting or even preventing HIV infection. More »
Biophysicists have discovered that fast-swimming, sulfur-eating microbes known as Thiovulum majus can form a two-dimensional lattice of rotating cells. Not only is this the first known example of bacteria spontaneously creating such a pattern, never before have living things been seen to move together in this way. More »
The designation is made in recognition of the many outstanding achievements of Rockefeller scientists, and in particular for ground-breaking discoveries by Oswald T. Avery, Colin M. MacLeod, Maclyn McCarty, Peyton Rous, and Emil C. Gotschlich. It will be formally announced at a dedication ceremony on April 8. More »
Intellectual property resulting from the discovery of specific DNA mutations linked to a rare and often deadly type of adolescent liver cancer, fibrolamellar hepatocellular carcinoma, has been dedicated to the public by the institutions that made the discovery, The Rockefeller University and the New York Genome Center, in the hope of accelerating progress toward the delivery of diagnostics and therapies for the devastating disease. More »
The rankings, released by the European Commission-funded U-Multirank survey, placed Rockefeller among the top five institutions in five key categories. Across the entire set of rankings, which incorporates data from 1,200 institutions, Rockefeller was the only institution to receive this many top slots.
A small number of children who catch the influenza virus fall so ill they end up in the hospital even while their family and friends recover easily. New research from Rockefeller helps explain why: a rare genetic mutation that prevents the production of a critical protein, interferon, that is needed to fight off the virus. More »
A detailed look at the African sleeping sickness parasite’s strategy for evading its hosts’ immune systems revealed that the blood parasites assume a surprising diversity of protein coat disguises. In fact, the number of disguises necessary to maintain a long-term infection appears to exceed the functional genes that encode them. More »
Rockefeller University researchers have successfully harnessed a technique, CRISPR-Cas9 editing, to use in an important and understudied species: the mosquito, Aedes aegypti, which infects hundreds of millions of people annually with the deadly diseases chikungunya, yellow fever, and dengue fever. More »
Tags: aedes aegypti, chikungunya, CRISPR, CRISPR-Cas9, dengue fever, gene editing, Laboratory of Neurogenetics and Behavior, Leslie B. Vosshall, Leslie Vosshall, mosquitos, yellow fever
New research reveals how cells sort out the RNA molecules destined to become gene-regulating microRNAs by tagging them. Because microRNAs help control processes throughout the body, this discovery has wide-ranging implications for development, health and disease, including cancer.
Researchers identify a molecular bridge between amyloid-β and chronic inflammation, two hallmarks of Alzheimer’s. That bridge, a molecular cascade known as the contact system, suggests the possibility of a simple blood test that could diagnose the disease early and non-invasively.
Experiments placed Sox9 at the crux of a shift in gene expression associated with hair follicle stem cell identity. The molecule first makes stem cell genes accessible so they can become active, then recruits other molecules that promote the expression of these genes in stem cells found at the base of the hair follicle. More »
Only a single treatment produced what researchers describe as “rapid, substantial, and durable clinical improvement” in patients. This raises the prospect of a treatment that could put this autoimmune disease of the skin into long-term remission. More »
The first mathematicians to receive the prize for writing about science, Strogatz and Stewart will be honored at a ceremony in Caspary Auditorium on the evening of Monday, March 30. More »
In experiments, the state of a simple brain network determined the likelihood a worm would move toward a delicious smell or ignore it. Scaled up to account for the more nuanced behaviors of humans, the research may suggest ways in which our brains process competing motivations. More »
Both the virus and liver cells need the microRNA molecules the liver produces to regulate its genes. Researchers found that by co-opting one microRNA, the virus may cause changes in gene expression in liver cells. More »