Tag Archives: Alexander Tarakhovsky

Antibodies, together with viral ‘inducers,’ found to control HIV in mice

Antibodies, together with viral ‘inducers,’ found to control HIV in miceA new strategy devised by researchers at Rockefeller University harnesses the power of broadly neutralizing antibodies, along with a combination of compounds that induce viral transcription, in order to attack latent reservoirs of HIV-infected cells in an approach termed ‘shock and kill.’ More »

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Influenza “histone mimic” suppresses antiviral response

Researchers have discovered a novel mechanism by which influenza viruses hijack key regulators of the human body’s normal antiviral response in order to slip by it undetected. The results have major implications for our understanding of the biology of the seasonal influenza virus and suggest a possible target for a new class of antiviral and anti-inflammatory drugs. More »

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Loss of epigenetic regulators causes mental retardation

New findings, published in recent issues of Neuron and Science, indicate that malfunction of a protein complex that normally suppresses gene activation causes mental retardation in mice and humans and may even play a role in promoting susceptibility to drug addiction. More »

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Core tenets of the “histone code” are universal

Histones, specialized proteins that package and control DNA, rely on a code to regulate gene transcription. Certain chemical modifications at histone tails act like a code that signals genes to turn on or off. Rockefeller University scientists show that nonhistone proteins recognize features of this histone code, and reveal an instance of histone mimicry. More »

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MicroRNA works with Ago2 protein to regulate blood cell development

A protein, but not its unique “slicer” component, maintains levels of and executes the function of a key biological regulator within cells, two processes that ultimately control the early development of blood cells. More »

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