Tag Archives: Alexander Tomasz

Rockefeller University Hospital shares $2.8 million contract to study preventing drug-resistant infections in the community

Rockefeller University Hospital shares $2.8 million contract to study preventing drug-resistant infections in the communityThe Community Acquired MRSA Project (“CAMP2”) will enroll patients with skin infections, provide English- and Spanish-language health education materials about community-acquired drug-resistant staph infections, and incorporate a home visit program by community health workers to evaluate the effectiveness of household decontamination in preventing reinfection and transmission. More »

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New research traces evolutionary path of multidrug resistant strep bacteria

In a landmark paper published this week in Science, scientists from Rockefeller University and the Sanger Institute have used full genome sequencing to identify the precise steps in the molecular evolution of Streptococcus pneumoniae. Their research shows the changes the genome of this bacterium has undergone in time and during its massive geographic spread over the globe. More »

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Researchers track evolution and spread of drug-resistant bacteria across hospitals and continents

Using high resolution genome sequencing, scientists have tracked a deadly strain of multidrug-resistant Staphylococcus aureus as it traveled between South America, Europe and Southeast Asia. The new technique provides an unprecedented view of how MRSA evolved over decades and across entire continents, as well as on the short timescale of a few weeks within a hospital in Thailand. More »

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Study of staph reveals how bacteria evolve resistance

By studying blood taken from a single patient over a period of months, Rockefeller University researchers have been able to trace how a common strain of bacteria adapted its genes to counteract the antibiotics used to try to kill it. More »

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Genetic ‘stress response’ may explain how bacteria resist drugs

Bacteria have a nasty habit of developing resistance to even our most powerful pharmaceuticals. But by tracking the staph infection of a single patient during a course of antibiotic treatment, Rockefeller University scientists have discovered new clues to how bacteria evolve resistance. More »

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Bacteria build walls to withstand antibiotics

Antibiotic resistant bacteria, which are proliferating in hospitals and causing major headaches for physicians, cheat death by finding ways to fortify their cell walls against the deadly drugs. Now, new research from the laboratory of Rockefeller’s Alexander Tomasz shows that one gene, called mecA, enables them to this. More »

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Superbug Update: Only a few families of Staphylococci cause most drug-resistant diseases in hospitals worldwide

The culprits behind antibiotic-resistant diseases now plaguing hospitals worldwide have been harboring a secret — one that Rockefeller scientists have recently exposed. It seems these infectious microbes termed Staphylococcus aureus are not independent criminals working alone. Rather, they are members of only a few massive “superbug” families, which have spread out and conquered the globe. More »

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Researchers Propose New Model of Drug Resistance in Staph Bacteria

Researchers at The Rockefeller University have established a new model to explain how the infectious “staph” bacterium evades several widely used antibiotics. They show that a protein previously thought to play no role in drug resistance in Staphylococcus aureus is, in fact, essential. More »

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Researchers Trace the Origin of a Widespread Antibiotic-Resistant “Superbug”

One of the most widely disseminated strains of an antibiotic-resistant bacterium responsible for hundreds of infections in European hospitals can be traced back to the 1950s, according to researchers at The Rockefeller University. Using the molecular tool called DNA fingerprinting, they have shown that this persistent lineage of Staphylococcus aureus is an expert at acquiring resistance to antibiotics. More »

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Rockefeller Researchers Identify Novel Penicillin-resistance Gene in Pneumonia Bacteria

Penicillin resistance of the bacterium that causes pneumonia, the pneumococcus, is a growing global health problem. Although S. pneumoniae was once considered to be routinely susceptible to penicillin, since the mid-1980s the incidence of resistance of this organism to penicillin and other antimicrobial agents has been increasing in the United States and throughout the world. Now, researchers at The Rockefeller University, reporting in the April 25 issue of the Proceedings of the National Academy of Sciences, show that resistance can be stopped by inactivating a pair of genes responsible for producing molecules called branched muropeptides, the availability of which appears to be essential for the bacterium to survive in the presence of penicillin. The finding suggests that the branched peptides may be a new drug target for fighting penicillin-resistant bacteria. More »

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Researchers Report Emergence of Antibiotic Resistance during Vancomycin Therapy

A team of researchers led by The Rockefeller University’s AlexanderTomasz, Ph.D., have described the case of a 79-year-old patientwhose death in a New York metropolitan area hospital last Marchwas associated with a bloodstream infection caused by a multidrug-resistantstrain of Staphylococcus aureus. The report, publishedin the Feb. 18 issue of the New England Journal of Medicine(NEJM), showed that the bacteria, which had decreased susceptibilityto vancomycin, could be treated effectively with a combinationof antibiotics. More »

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Scientists Track Spread of Antibiotic-Resistant Bacteria in 12 New York City Hospitals

A team of researchers led by scientists from The Rockefeller University and the Public Health Research Institute (PHRI) used molecular fingerprinting techniques to track the spread of methicillin-resistant Staphylococcus aureus (MRSA) in 12 hospitals in the New York City metropolitan area. The findings, published in the July issue of the Journal of Infectious Diseases, confirms the prevalence of antibiotic-resistant strains of staph in New York City. More »

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Bacteria Steal Genes, Spread Antibiotic Resistance

A strain of the bacterium Streptococcus pneumoniae, resistant to the six most frequently used antibiotics and spread worldwide including U.S. day care centers and hospitals, appears to disguise itself from the immune system by changing its coat, report scientists from The Rockefeller University. More »

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