Tag Archives: Ali H. Brivanlou

Using geometry, researchers coax human embryonic stem cells to organize themselves

Using geometry, researchers coax human embryonic stem cells to organize themselvesBy confining colonies of human embryonic stem cells to tiny circular patterns on glass plates, researchers have for the first time coaxed them into organizing themselves just as they would under natural conditions. More »

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New gene for hair loss identified

Researchers have discovered a gene involved in hair loss that may lead to new, non-hormonal therapies for baldness. The work, by researchers at Rockefeller, Columbia and Stanford universities, reveals that a mutation in a gene called APCDD1 inhibits a signaling pathway that was known to affect hair growth in mice but never before in humans. More »

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Rockefeller human embryonic stem cell lines now available through NIH registry

Two human embryonic stem cell lines, derived using private funds, are among the first 13 human embryonic stem cell lines for use in NIH-funded research under the NIH Guidelines for Human Stem Cell Research adopted in July 2009. More »

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For different species, different functions for embryonic microRNAs

Researchers at The Rockefeller University have discovered that a family of microRNAs that regulates early embryonic development is evolutionarily conserved from fish to amphibians and humans, but its function is not. The findings are a warning: Scientists should not assume that what they learn about microRNAs in animal studies will hold true for people. More »

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Rockefeller receives new $4.8 million state grant to fund stem cell research

The grant from New York will establish new facilities for studying the molecular basis of how stem cells are maintained and how they differentiate. More »

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Newly identified gene may prompt pancreas cells to form

Researchers uncover key genetic signals involved in how the pancreas begins forming, a finding they say might lead to regenerative therapies for patients with certain forms of diabetes, whose pancreases no longer function. More »

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From frogs to humans, brains form the same way

Scientists had believed that mammals and amphibians, distinctly different animals, have distinctly different developmental patterns when it comes to the nervous system. But a new model of ”mammalian neural induction“ provides a bridge across the evolutionary gap. More »

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Human stem cells can contribute to a developing mouse embryo, despite evolutionary differences

A new line of human embryonic stem cells, created using private funds, has been coaxed to grow inside a developing mouse embryo, giving scientists the unique opportunity to observe as the undifferentiated cells replicate and specialize. The results offer a groundbreaking means of both elucidating the beginning of human embryonic development and serving as a starting point from which to understand their potential therapeutic secrets of human embryonic stem cells. More »

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Feeder-free system for maintaining embryonic stem cells pioneered at Rockefeller University

Rockefeller University researchers, in collaboration with two European scientists, have devised a system for maintaining human embryonic stem cell lines that excludes the need for troublesome mouse feeder cells.
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Genetic clues to stem cells’ unlimited potential

As an embryologist, Ali H. Brivanlou wants to know every genetic route taken by a small mass of undifferentiated, or unformed, embryonic cells as they develop into an organism. More »

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First quantum dots applied to living organism

Quantum dots are nano-sized crystals that exhibit all the colors of the rainbow due to their unique semiconductor qualities. These exquisitely small, human-made beacons have the power to shine their fluorescent light for months, even years. But in the near-decade since they were first readily produced, quantum dots have excluded themselves from the useful purview of biology. Now, for the first time, this flexible tool has been refined, and delivered to the hands of biologists. More »

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Tidying Up Transcription Factors

Fifty years ago, in the early days of biology, so little was known about the cell that all of the proteins outside of its nucleus were grouped into one big “cytoplasmic soup.” Now, as the list of known cellular ingredients continues to expand beyond the capacity of any recipe card, two Rockefeller University scientists are taking a step back to ask whether there might be a better way to organize the current thinking about a particularly important class of proteins inherent to all living cells. More »

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Researchers Discover Promoter of Nerve Tissue in Frogs

Researchers at The Rockefeller University have discovered that a protein known to be involved in the early development of embryos indirectly leads to the formation of nerve tissue in frogs. The findings, reported in the March 22 issue of Nature, may have applications in such neurodegenerative diseases as Alzheimer’s and Parkinson’s. More »

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