Tag Archives: cancer

Promising class of new cancer drugs causes memory loss in mice

Promising class of new cancer drugs causes memory loss in miceNew research shows that a family of experimental cancer drugs can induce neurological changes in mice. The findings underscore the need for more research to determine whether these compounds can enter the brain, where they potentially might cause side effects such as memory loss. More »

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Fragments of tRNA suggest a novel mechanism for cancer progression

Fragments of tRNA suggest a novel mechanism for cancer progressionResearchers discover that particular genetic fragments, of a type of RNA known as transfer RNA, or tRNA, appear to be capable of reducing the growth and spread of breast cancer cells. More »

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Chemical tag marks future microRNAs for processing, study shows

Chemical tag marks future microRNAs for processing, study showsNew research reveals how cells sort out the RNA molecules destined to become gene-regulating microRNAs by tagging them. Because microRNAs help control processes throughout the body, this discovery has wide-ranging implications for development, health and disease, including cancer.
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Research implicates metabolic process of the liver in the spread of colorectal cancer

Research implicates metabolic process of the liver in the spread of colorectal cancerBy identifying genes that become activated in cancer cells that successfully metastasize to the liver, researchers at Rockefeller have implicated metabolic processes within the liver as a possible means by which starving transient cancer cells can go on to form deadly new colonies. More »

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Cancer biologist and physician Sohail Tavazoie is promoted to associate professor

Cancer biologist and physician Sohail Tavazoie receives promotionTavazoie, who joined Rockefeller in 2009, works to understand how cancer cells become able to escape a tumor and invade other organs, a process known as metastasis. He searches for genes and molecular pathways cancer cells exploit in order to metastasize and, with that knowledge, hopes to develop future treatments to prevent or interfere with the process.
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Discovery of pro-metastasis protein reveals mysterious link to neurodegeneration

Discovery of pro-metastasis protein reveals mysterious link to neurodegenerationMice injected with metastatic breast cancer cells showed less metastasis when researchers silenced the protein TARBP2 in these cells. TARBP2 appears to promote metastasis in part by blocking suppressor genes, including two linked with neurodegeneration. More »

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In the News – Daily Mail UK – Tavazoie

How spread of breast cancer could be stopped “Professor Sohail Tavazoie, who led the research, said: ‘If we learn more about how this regulation works, we may in the future be able to generate drugs that prevent this protein from … More »

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Daniel Schramek awarded Regeneron Prize for Creative Innovation by a Postdoctoral Fellow

Schramek, one of just two individuals receiving the annual award, is being recognized for his proposal of a project that used sequence-based personalized medicine to treat the most devastating features of cancer. The award comes with a $50,000 prize and a $5,000 donation to support seminars at Rockefeller. More »

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Drug is identified that could block the spread of melanoma

Researchers have found a promising new route to slowing or even preventing melanoma cells from spreading within the body. Using a compound that targets a hormone receptor, the team found they could reduce tumors’ recruitment of blood vessels, a process necessary for metastasis. More »

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Researchers discover unusual genetic mutation linked to adolescent liver cancer

In the race for better treatments and possible cures, rare diseases are often left behind. In a collaboration of researchers at The Rockefeller University, Memorial Sloan Kettering Cancer Center and the New York Genome Center, an unusual mutation has been found that is strongly linked to one such disease: a rare liver cancer that affects teens and young adults. More »

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New RNA interference technique finds seven genes for head and neck cancer

The technique, created by scientists in Rockefeller’s Laboratory of Mammalian Cell Biology and Development, attaches short pieces of RNA to highly concentrated viruses and uses ultrasound to inject the viruses into mouse embryos. It takes a fraction of the resources and much less time than using knockout mice to conduct genetic screens, and can assess about 300 genes in a single mouse in as little as five weeks. More »

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Starr collaboration illuminates mysterious pathway to immortality in cancer cells

A detailed analysis of a large panel of so-called ALT cell lines shows that they frequently undergo chromosomal changes and are impaired in their ability to detect and repair damage in their DNA. The work suggests a mechanism by which 10 to 15 percent of human cancers develop. More »

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In cancer, molecular signals that recruit blood vessels also trigger metastasis

Cancer cells are most deadly when they’re on the move – able not only to destroy whatever organ they are first formed in, but also to create colonies elsewhere in the body. New research has now shown how a small RNA prevents the recruitment and formation of blood vessels near cancer cells destined to become metastases, a process that must occur in order for them to grow. The scientists say that if drugs could be developed that act on the pathways regulated by this microRNA, they might be able to block the metastatic process and prevent some breast cancers from becoming deadly. More »

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