Tag Archives: Charles M. Rice

In the News – New York Times – Rice

Lasker Awards Given for Work in Physiology, Virology and Science Education   “At the time, researchers thought the work might be as simple as inserting that newly sequenced RNA into cultured cells and watching it replicate. But in experiment after … More »

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Charles M. Rice wins Lasker Award for groundbreaking work on the hepatitis C virus

Charles M. RiceThis year’s Lasker-DeBakey Clinical Medical Research Award honors Charles M. Rice, who developed a system to study the replication of the virus that causes hepatitis C, an advance that has led to safe and powerful new drugs that cure the disease. The award, considered the most coveted American prize in medical science, will be presented on September 23 in New York City. More »

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Charles Rice wins Belgium’s highest scientific prize

Charles Rice wins Belgium’s highest scientific prizeRice has received the 2016 InBev-Baillet Latour Health Prize for his fundamental discoveries in the field of infectious diseases. The award, given by the Baillet Latour Fund to recognize outstanding contributions in biomedical research for the benefit of human health, is Belgium’s most important scientific prize. More »

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A virus common among livestock depends on a microRNA to replicate

A virus common among livestock depends on a micro-RNA to replicate Increasingly, scientists are finding that small RNA molecules might be effective targets for antiviral drugs. Using a new screening method, Rockefeller researchers now show that a number of RNA viruses need access to micro-RNAs produced by their host cells to replicate. More »

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Key to blocking influenza virus may lie in a cell’s own machinery

Key to blocking influenza virus may lie in a cell’s own machineryResearchers have found that the immune system fights a flu infection by turning off cellular enzymes the virus needs to put the final touches on new viral particles. The unfinished particles cannot spread infection to new cells. More »

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Scientists create humanized mouse model for hepatitis C

A team of researchers led by scientists in the Laboratory of Virology and Infectious Disease at Rockefeller have, for the first time, recreated a portion of the hepatitis C virus life cycle in a mouse with a functional immune system. The new mouse model will enable scientists to test molecules that block entry of the hepatitis C virus into cells as well as potential vaccine candidates. More »

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Researchers modify yellow fever vaccine to fight malaria

A genetically modified vaccine originally used to eradicate yellow fever could be the key to stopping a mosquito-borne scourge that afflicts much of the developing world. More »

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Scientists visualize how a vital hepatitis C virus protein moves along its nucleic acid substrate

In a series of three snapshots that recapitulate the coordinated actions, scientists reveal how a protein essential for the replication of the hepatitis C virus moves along its nucleic acid substrate. The finding illustrates the nucleotide-dependent changes of interactions between the protein, known as NS3, and DNA, work that suggests some of the most feasible strategies to date to block the action of this largely unexplored drug target. More »

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Multitasking may be Achilles heel for hepatitis C

Hepatitis C, a formidable virus that affects 130 million people worldwide, is nursing some pretty impressive bruises. By knocking out sections and subsections of one of its proteins, scientists reveal weak spots in the virus’s armor and gain new momentum for developing drug targets for sufferers of the disease. More »

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Discovery could lead to a new animal model for hepatitis C

The hepatitis C virus is interested in only one thing: human liver cells. That has been one of scientists’ greatest frustrations in their efforts to study the virus, and has hampered the development of useful animal models for the disease. But now, in a major leap forward, scientists have identified a protein that allows this uniquely human pathogen to enter mouse cells, a finding that could lead to a vaccine or to new treatments. More »

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By imaging living cells, researchers show how hepatitis C replicates

The hepatitis C virus is a prolific replicator, able to produce up to a trillion particles per day in an infected person. By using live imaging, researchers now know how. Their research shows that within an infected cell, the virus uses a combination of big viral factories and tiny, mobile replication complexes to efficiently churn out copies. More »

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New theory suggests how hepatitis C may cause rare immune disease

In 1990 researchers observed that most patients with hepatitis C also develop a rare autoimmune disease called mixed cryoglobulinemia, a condition that frequently leads to cancer, arthritis or both. Now scientists at Rockefeller University say that a decade-old explanation of how one disease causes the other is likely wrong, and instead offer a new — albeit controversial — theory of their own. More »

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Hepatitis C virus blocks ‘superinfection’

There’s infection and then there’s superinfection – when a cell already infected by a virus gets a second viral infection. But some viruses don’t like to share their cells. New research from Rockefeller University shows that the hepatitis C virus, which infects cells in the liver and can cause chronic liver disease, can block other hepatitis C variants from infecting the same cell. More »

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Kety protein for Hepatitis C entry identified

For as many as 200 million people worldwide infected with hepatitis C, a leading cause of chronic liver disease, treatment options are only partially effective. But new research by Rockefeller University scientists points to a potential new target for better drugs: a key protein that resides in human liver cells that hepatitis C requires for entry. More »

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Researchers show laboratory hepatitis C strain is also infections in animal models

For many years scientists have struggled with an inability to efficiently culture the hepatitis C virus in the laboratory. Now, researchers at Rockefeller University have overcome several obstacles and successfully shown that a strain of HCV they created in the laboratory, which can efficiently be cultured in vitro, is also infectious in animals. More »

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Building a better vaccine

By studying how the yellow fever vaccine creates a potent, lifelong immunity after a single shot, Rockefeller scientists say they could unlock secrets that will help design new vaccines to target not only the influenza virus, but perhaps other infectious diseases such as HIV or hepatitis C. More »

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Researchers create infectious hepatitis C virus in a test tube

New system will allow scientists to study every stage of the HCV life cycle and develop drugs to treat this life-threatening disease. More »

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Two Rockefeller scientists elected to National Academy of Sciences

The National Academy of Sciences announced the election of 72 new members this morning, including two Rockefeller University scientists. More »

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Researchers Identify Key to Genetic Replication in Hepatitis C Virus

Researchers at Rockefeller University and Washington University School of Medicine in St. Louis have identified mutations in a protein of certain strains of hepatitis C virus (HCV) that allow these strains to replicate more vigorously in human cell culture. The finding allows scientists to improve an essential tool for studying the virus and suggests a starting point for the design of effective vaccines. More »

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First Hepatitis-C Center in Northeast Region Established By Rockefeller University, New York-Presbyterian, and Weill Cornell

New York, NY–Three neighboring New York City medical institutions–The Rockefeller University, NewYork-Presbyterian Hospital, and Weill Medical College of Cornell University–have jointly established the Center for the Study of Hepatitis C, the first major center in the Northeast region devoted specifically to the disease. Renowned virologist Charles M. Rice, Ph.D., who recently made the first infectious clone of the virus, will join The Rockefeller University faculty and serve as both scientific and executive director of the multi-institutional center. More »

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