Tag Archives: chromatin

Study links epigenetic processes to the development of the cerebellar circuitry

Study links epigenetic processes to the development of the cerebellar circuitryResearchers have, for the first time, described the pivotal changes responsible for controlling the formation of the part of the brain that allows us to learn and execute complex movements. These changes involve modifications to chromatin, which is DNA packaged with protein. More »

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Experiments explain the events behind molecular ‘bomb’ seen in cancer cells

Experiments explain the events behind molecular ‘bomb’ seen in cancer cellsSometimes, in cancer cells, a part of a chromosome looks like it has been pulverized, then put back together incorrectly, leading to multiple mutations. New research from The Rockefeller University describes the cellular events leading to this molecular explosion, which serves as a precursor to cancer. More »

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Study suggests new way to help the immune system fight off sleeping sickness parasite

Study suggests new way to help the immune system fight off sleeping sickness parasiteThere are currently few treatments for the disease, and those that exist have substantial side effects. A new study reveals a method, involving epigenetic mechanisms, that causes the African sleeping sickness parasite to change into a new state, potentially making it easier for the host immune system to eliminate it. More »

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Discovery links shift in metabolism to stem cell renewal

Discovery links shift in metabolism to stem cell renewalNew research links stem cell metabolism with those cells’ decision to pick a fate or renew themselves. In experiments, exposure to a key metabolite called alpha-ketoglutarate enhanced the renewal of mouse embryonic stem cells. More »

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C. David Allis wins the 2015 Breakthrough Prize in Life Sciences

C. David Allis wins the 2015 Breakthrough Prize in Life Sciences’Allis is recognized for his foundational research on the unexpected regulation of gene activation by modifications to proteins that package DNA, work with implications for many diseases including cancer. The Breakthrough Prize is worth $3 million, making it the richest prize in the life sciences, roughly double the Nobel Prize. More »

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David Allis, pioneer in epigenetics, to receive prestigious Japan Prize

Allis’s discovery that chemical “tags” bind to specific sections of histone proteins in order to activate or silence nearby genes has ignited the field of epigenetics, a relatively new area of study which explores the inheritance of physical changes that cannot be traced back to mutations in the DNA sequence. The Japan Prize, worth approximately half a million dollars, is among the most prestigious prizes in science. More »

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