Tag Archives: circadian clock

New research helps to explain how temperature shifts the circadian clock

New research helps to explain how temperature shifts the circadian clockOne important aspect of the internal time-keeping system continues to perplex scientists: its complex response to temperature, which can shift the clock forward or backward, but cannot change its 24-hour period. New experiments help explain how this is possible. More »

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Scientists identify stomach’s timekeepers of hunger

The problem with dieting is that it leaves you hungry. But scientists have now identified specific cells in the stomach that are behind the body’s craving for food. In new research that has implications for the treatment of obesity, scientists have shown that these cells release the hormone ghrelin, which in animals causes foraging behavior even when they’re not hungry. The findings could help researchers develop drugs that would curb dieters’ appetites before that first bite. More »

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A snooze button for the circadian clock

Humans, and most other organisms, have 24-hour rhythms that are regulated by a precise molecular clock that ticks inside every cell. A new study by Rockefeller University researchers shows how two molecules interact to regulate this clock’s cycle and uncovers how that switch can go haywire, identifying a potential cause of heritable sleep disorders. More »

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Two forces of arousal converge on the “satiety center” of the brain

The light-dark cycle, under normal conditions, does a pretty good job of regulating mental alertness — animals are typically alert during one part of the cycle and not so alert during the other. New research from Rockefeller University shows how changing the timing of a meal can disrupt these patterns and reveals which regions of the brain are involved. More »

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Single circadian clock regulates flies’ response to light and temperature

Circadian rhythms allow animals to align their bodies to the earth’s rotation. Now, new research shows that the same molecular clock that flies use to sync themselves to the sun’s patterns is what allows them to sync to temperature patterns, too. More »

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New function for protein links plant’s circadian rhythm to its light-detection mechanism

Plants know when to flower because they set their circadian clocks by measuring the length and quality of the light they receive. Now Rockefeller University researchers have found a new function for the protein SPA1, showing that it serves as an important link between a plant’s light-detection proteins and the rest of its circadian clock machinery. More »

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New research shows how proteins make biological clock tick

By looking inside a single cell and following two different proteins over several hours, Rockefeller scientists have turned the old model of the cellular circadian clock on its head. When the two proteins come together, the scientists say, they create a six-hour timer that appears to tightly regulate the cell’s circadian rhythm. More »

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Scientists Identify New Gene That Controls Sleep/Wake Cycle

A newly discovered gene called double-time regulates the molecular cycles underlying circadian rhythms, scientists from The Rockefeller University report in two papers featured on the cover of the July 10 issue of Cell. The researchers also identified the molecular mechanism that allows this gene to work. More »

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Light Sets the Molecular Controls of Circadian Rhythm

Light sets the circadian rhythm by eliminating a key protein needed for the molecular mechanism of the body’s clock, according to scientists in the March 22 Science. The findings, from fruit fly studies, may help explain light’s effect on the daily cycle that influences sleep, mental alertness, pain sensitivity and temperature and hormone levels. More »

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Circadian Rhythm Set by Pairing of Two Proteins

The molecular control of the daily cycle known as circadian rhythm lies in the pairing of two proteins, scientists report in a trio of papers in the Nov. 3 Science. The findings, from fruit fly studies, promise to help scientists better understand human, animal and plant circadian rhythms, which influence cell and body biochemistry, health, aging and behavior. More »

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