Tag Archives: CRISPR

In the News – Stat – Tessier-Lavigne

Scientists solve CRISPR’s ‘Energizer Bunny’ problem   “‘It works beautifully,’ Tessier-Lavigne said. With standard CRISPR-Cas9, 6 percent to 35 percent of the edits were clean, without random insertions and deletions due to Cas9’s repeated cuts, but with their upgrade, the … More »

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Luciano Marraffini, among the first scientists to plumb the workings of the CRISPR-Cas system, is promoted to associate professor

Luciano Marraffini, among the first scientists to plumb the workings of the CRISPR-Cas system, is promoted to associate professorLuciano Marraffini is exploring an immune response used by bacteria to defend against viruses. His work is mainly focused on understanding the basic biology and evolution of microorganisms, but it also has implications for the development of gene-editing technologies. More »

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Alex Gitlin and Wenyan Jiang win 2016 Weintraub Graduate Student Awards

Alex Gitlin and Wenyan Jiang win 2016 Weintraub Graduate Student AwardsAlex Gitlin and Wenyan Jiang are two of 12 recipients of this prestigious prize, which is given to graduate students at or near the completion of their studies in the biological sciences. Winners are chosen for the quality, originality, and significance of their thesis research. More »

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A newly discovered form of immunity helps explain how bacteria fight off viruses

A newly discovered form of immunity helps explain how bacteria fight off virusesScientists have discovered an immune-defense mechanism in bacteria that allows these microorganisms to respond to viral infections with remarkable precision. Their findings could have implications for the development of new therapies against infectious diseases. More »

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Luciano Marraffini receives the Hans Sigrist Prize for work on antibiotic resistance

Luciano Marraffini receives the Hans Sigrist Prize for work on antibiotic resistanceThis award, bestowed by the University of Bern, honors Marraffini for his work developing a new approach to fight antibiotic resistance. Marraffini studies CRISPR-Cas systems, which enable some bacteria to acquire immunity against viruses, and is investigating ways to use them to fight off microbial pathogens. More »

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Rockefeller scientists resolve long-standing debate over how many bacteria fight off invaders

For years, researchers have puzzled over conflicting results about the workings of type III CRISPR-Cas systems, a type of immune system found in many species of bacteria. Some data showed that this mechanism would target the virus’s DNA, while other experiments suggested it could only disable a virus once it had started replicating itself. New results suggest both mechanisms play a role.
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Researchers master gene editing technique in mosquito that transmits deadly diseases

Researchers master gene editing technique in mosquito that transmits deadly diseasesRockefeller University researchers have successfully harnessed a technique, CRISPR-Cas9 editing, to use in an important and understudied species: the mosquito, Aedes aegypti, which infects hundreds of millions of people annually with the deadly diseases chikungunya, yellow fever, and dengue fever. More »

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Virus-cutting enzyme helps bacteria remember a threat

Virus-cutting enzyme helps bacteria remember a threatThe enzyme Cas9 is well known for its ability to make precise cuts in a genome. New research reveals a new role for Cas9 in its native bacteria: helping the microbial immune system acquire a memory of an invading virus. More »

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‘Programmable’ antibiotic harnesses an enzyme to attack drug-resistant microbes

“Programmable” antibiotic harnesses an enzyme to attack drug-resistant microbesBy co-opting a system bacteria normally use to defend themselves, researchers targeted and killed off colonies of the antibiotic resistant Staph cells on mouse skin. The treatment left behind the drug-susceptible microbes. More »

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Discovery reveals how bacteria distinguish harmful versus helpful viruses

Discovery reveals how bacteria distinguish harmful versus helpful virusesViruses can kill bacteria, or viruses can help the microbes by lending them potentially useful genes. New research shows Staph bacteria have an immune system capable of distinguishing dangerous invaders from potentially beneficial ones. More »

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Researchers demonstrate how ‘interfering’ RNA can block bacterial evolution

Experiments in pneumococcal bacteria show how an RNA interference mechanism known as CRISPR can be used to prevent the uptake of genetic material from the environment. Harnessing this mechanism could be a new way to manipulate bacterial evolution in ways that might be medically useful. More »

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Microbiologist to join Rockefeller faculty

Rockefeller’s newest faculty member is Luciano Marraffini, a microbiologist who studies how bacterial pathogens modulate the transfer of foreign DNA into their genomes. His work sheds light on how bacteria such as Staphylococcus aureus evolve, including how they gain the ability to resist antibiotic drugs. More »

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