Tag Archives: dendritic cells

Research shows how antibodies produce vaccine-like effect against tumors

Research shows how antibodies produce vaccine-like effect against tumorsAntibody therapy not only kills cancerous cells, it can confer lasting protection by priming the immune system to remember a tumor. Scientists have found this process centers on antibody-binding receptors found on two types of immune cells. Their results suggest ways to improve anti-cancer treatments. More »

Tags: , , , , , , , , ,

Adjunct faculty member Kayo Inaba receives L’Oréal-UNESCO Women in Science award

Inaba, a member of Michel Nussenzweig’s Laboratory of Molecular Immunology who previously worked in Ralph Steinman’s lab, is known for her work on specialized immune cells called dendritic cells. Inaba is being honored as the Asia-Pacific recipient of the L’Oréal-UNESCO Women in Science award, which supports eminent women in science throughout the world who are working in life and physical sciences. More »

Tags: , , ,

Resident protection

To keep the body safe, the immune system enlists more than one form of protection. Rockefeller University scientists, working in collaboration with researchers at New York University, are learning about an important, but little-known, network of dendritic cells in lymph nodes through innovative, live-action imaging. More »

Tags: , ,

Michel C. Nussenzweig elected to National Academy of Sciences

Michel C. Nussenzweig, Sherman Fairchild Professor and head of the Laboratory of Molecular Immunology, was elected a member of the National Academy of Sciences at the Academy’s annual meeting today, in recognition of his deep contributions to our understanding of the workings of the innate and adaptive immune systems. More »

Tags: , ,

New class of ‘dancing’ dendritic cells derived from blood monocytes

The discovery of a new class of dendritic cells that stem from blood monocytes in mice promises to accelerate research into clinical therapies that use these cells, known to be the sentinels of the immune system. Much research has been done on classical dendritic cells, which are found in the lymph tissues of mice. But these are hard to come by in the case of humans. The new technique may allow the generation of “authentic” dendritic cells from human blood samples, however, which could make it much easier to advance dendritic cell-based vaccines and cancer treatments that are under development now. More »

Tags: , , , ,

New HIV vaccine trial first to target dendritic cells

HIV has been able to outmaneuver every vaccine that’s been tried on the virus since it was first discovered in 1981. But no vaccine has yet to directly employ what is arguably the most powerful weapon the human immune system, the dendritic cells that orchestrate the body’s response to infection. Now that’s about to change. Researchers at Rockefeller University, where dendritic cells were discovered in 1973, are building on decades worth of research to launch a novel vaccine trial in hopes of mustering an immune response strong enough to defeat the deadly virus. It’s the first clinical trial of a dendritic cell based vaccine against infection, and researchers hope it will mark a turning point in the battle against AIDS. More »

Tags: , , , ,

First evidence that the brain’s native dendritic cells can muster an immune response

Since their initial discovery in 1973, dendritic cells, the sentinels of the immune system, have turned up in a number of places other than the immune organs. They stand guard in the heart, for instance, and in 2008, the first population native to the brain was identified. New research shows that dendritic cells are not only present in the brain, but active, too. They confront foreign substances and seem to form a barrier between healthy and stricken brain tissue following a stroke. More »

Tags: , , , ,

To spread, skin cancer attacks immune dendritic cells

By knocking out or beguiling dendritic cells, some cancer cells can slip the defenses of the immune system and sack the unsuspecting body. Dendritic cells taken from one of the most common types of skin cancer have most of the known genetic and physiologic hallmarks of their able-bodied fellows in healthy skin tissue. But they fail to stimulate an effective immune response. More »

Tags: ,

Scientists show how a neuron gets its shape

For the brain to work, neurons have to be connected in the right places. Now, new research shows that rather than growing like the branches of a tree — extending outward — certain neurons work backward from their destination, dropping anchor and stretching their dendrites behind them as they crawl away. More »

Tags: ,

Research defines dendritic cell lineage

For more than 30 years, controversy has reigned over the question of how exactly to differentiate dendritic cells from their immune cell cousins, the monocytes. Now, research published in Science identifies a precursor to classical spleen dendritic cells that defines where such cells diverge from monocytes. The findings could have important implications for research on dendritic cell-based vaccines all over the world. More »

Tags: ,

Dendritic cells as a new player in arteries and heart valves

Discovered by Ralph M. Steinman in 1973, dendritic cells have been implicated in early immune responses such as graft rejection, resistance to tumors and autoimmune diseases. New research shows that these relatively rare immune cells may play a role in heart disease as well. Experiments show that dendritic cells project their dendrites into the bloodstream, where they can capture foreign invaders and turn them over to T cells for destruction. More »

Tags: ,

DNA vaccines get a boost from dendritic cells

DNA vaccines show promise for fighting off HIV, SARS, influenza and other diseases, but aren’t yet potent enough for human use. Adding dendritic cells to the mix may provide the oomph they need. More »

Tags: ,

First evidence of native dendritic cells in brain

In a finding that has the potential to change the way researchers think about the brain, Rockefeller scientists have found immunity-directing dendritic cells where they’ve never been seen before: among the organ’s neurons and connective cells. More »

Tags: ,

Altering the balance of immune-cell receptors could help treat cancer and autoimmune diseases

Researchers believe they can target receptors on the surface of dendritic cells. By doing so, they may be able to tune a person’s immunity: up to help fight cancer, or down to depress autoimmune activity. More »

Tags: ,

Immune cells can simultaneously stimulate and inhibit killer cell activity

Natural killer cells are taught to attack invaders by dendritic cells, which alter themselves to look a little bit like the invading microbe. Now, new research shows how the dendritic cells are able to prevent their newly trained pupils from turning on their teachers. More »

Tags: ,

Rockefeller immunologist receives Lasker Award for Basic Medical Research

This year’s Albert Lasker Award for Basic Medical Research honors Rockefeller University’s Ralph M. Steinman, who discovered dendritic cells, the preeminent component of the immune system that initiates and regulates the body’s response to foreign antigens. More »

Tags: , ,

Dendritic cells stimulate production of immune-repressing T cells

Regulatory T cells, which are important for suppressing immune response, could potentially be exploited for different immune therapies. A new study takes researchers a step closer to this goal, showing that the suppressor cells are generated by dendritic cells — cells already known for their ability to direct immune system response. More »

Tags: , ,

Common immune cell marker shown to be off target

In a case of mistaken identity, an immune cell marker that researchers have been using for 15 years to identify a specific type of skin dendritic cell doesn’t identify dendritic cells at all. Instead, the marker, called FXIIIA, is highlighting macrophages — a completely different group of immune cells. More »

Tags: , ,

Subset of dendritic cells could be used to fight infection

Despite the prevalence of the parasitic disease leishmaniasis in tropical countries, there is currently no vaccine to prevent its transmission. But a new study shows that targeting a specific set of immune cells may result in a substantial boost in immune response. More »

Tags: , ,

Dendritic cells are replenished from blood

New research helps resolve an ongoing debate about where dendritic cells, which help direct the body’s immune responses, originate and how they multiply, especially in the spleen and lymph system. The findings are especially important for scientists developing immune-cell-targeted vaccines. More »

Tags: ,