Tag Archives: depression

Resistance to antidepressants linked to metabolism

Resistance to antidepressants linked to metabolismRecent findings by a Rockefeller University team might offer new clues about why some patients don’t respond to antidepressants. While investigating resistance to treatment in rats, the scientists uncovered changes in genes that control metabolism. More »

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Researchers find new signs of stress damage in the brain, plus hope for prevention

Researchers find new signs of stress damage in the brain, plus hope for preventionNew research shows that when mice experience chronic stress, neurons within part of their brain’s fear and anxiety center, the amygdala, retract. It also suggests how such changes could be prevented. More »

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Study offers insight on how a new class of antidepressants works

Study offers insight on how a new class of antidepressants worksThe experimental drugs target brain cells’ ability to respond to the chemical messenger glutamate, however, it has been unclear how they work. The recent discovery of a molecular amplification system helps explain how the drugs alter signaling in particular neurons to achieve an antidepressant effect. More »

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Research hints at why stress is more devastating for some

Research hints at why stress is more devastating for someSome bounce back from stress, while others struggle with it, even developing anxiety and depression as a result. In experiments with mice, researchers have revealed the molecular origins of this so-called stress gap.
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Brain protein may be a target for fast-acting antidepressants

It takes weeks or months for the effect of most antidepressants to kick in, time that can feel like an eternity to those who need the drugs the most. But new research suggests that a protein called p11 may be the key to developing drugs that begin to work in as little as two days. More »

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Mice on Prozac help scientists find better depression treatments

By comparing mice that had been given Prozac with mice given an alternate drug, researchers have identified a new class of chemicals that could offer better control over serotonin and more effective treatments for the debilitating mental illness. More »

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Scientists, linking gene with serotonin and depression, offer insights to new treatments

New research shows that a gene called p11 is closely related to serotonin transmission in the brain – and may play a key role in determining a person’s susceptibility to depression. Reported today in the journal Science, the researchers say their discovery could lead to new treatments for certain mental disorders. More »

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More Studies Shed Light on How Prozac Works

Nobel laureate Paul Greengard, Ph.D., and other Rockefeller University scientists have illuminated, in laboratory mice, new details of the complex chemical interaction in the brain that is generated by Prozac, the widely prescribed drug for depression. More »

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