Tag Archives: DNA repair

DNA strands often “wiggle” as part of genetic repair

DNA strands often “wiggle” as part of genetic repairNew research indicates that every time a double-stranded break occurs in DNA strands, the damaged ends move about during repair. Scientists believe a better understanding of this mysterious mechanism could improve the use of cancer treatments, some of which manipulate DNA repair in malignant cells. More »

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New findings shed light on fundamental process of DNA repair

New findings shed light on fundamental process of DNA repairScientists have identified a new component of the molecular machinery a cell uses to repair damaged DNA. The discovery adds important knowledge about a fundamental life process that protects from diseases such as cancer. More »

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Agata Smogorzewska, who studies DNA repair, promoted to associate professor

Agata Smogorzewska, who studies DNA repair, promoted to associate professorSince arriving in 2009, Smogorzewska has investigated a type of DNA repair that occurs during cell division when cells remove misplaced links between DNA strands. To identify the genes and understand the molecular mechanisms involved, she investigates this repair through the lens of rare genetic disorders. More »

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Mutations linked to genetic disorders shed light on a crucial DNA repair pathway

Mutations linked to genetic disorders shed light on a crucial DNA repair pathwayResearchers have identified two new genes in which mutations can interfere with a cell’s ability to remove misplaced links between DNA strands, and, as a result, cause a rare genetic disorder known as Fanconi anemia. These discoveries offer new insight on a repair process critical to maintaining certain tissues and preventing cancer. More »

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New Rockefeller faculty member studies mechanisms of DNA repair

Agata Smogorzewska, a physician-scientist whose research focuses on DNA repair and on the molecular basis of Fanconi anemia, a genomic instability syndrome that leads to leukemia and other forms of cancer, will join The Rockefeller University as head of the Laboratory of Genome Maintenance. More »

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Scientists discover how a well-known protein repairs broken DNA ends

In the first-ever study to film live footage of protected and unprotected telomeres, scientists have discovered how a protein called 53BP1 helps fuse dangly DNA ends in need of repair. The findings could change how scientists think about double-stranded DNA breaks — the most lethal type of DNA damage — and also leads to new insights about how the human immune system adapts to new threats. More »

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Researchers solve structure of an enzyme vital for DNA repair

As freshly made DNA coils into a chromosome, cells recognize DNA damage in need of repair. Now, a new study shows how an enzyme known as Rtt109, which creates slack in the coils in order to allow the cell access to fix the errors, is regulated. More »

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Modular structure enables TRCF protein to both halt transcription and repair DNA

Using x-ray crystallography, Rockefeller scientists have now solved the structure of a protein — called Transcription-Repair Coupling Factor or TRCF — that plays a dual role in DNA transcription repair. The results show that TRCF employs a modular structure which would allow for conformational changes so that TRCF’s recruitment of the repair machinery doesn’t interfere with its interruption of transcription. More »

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Molecular image of genotoxin reveal how bacteria damage human DNA

The three-dimensional structure of a DNA-damaging, bacterial toxin has been visualized by scientists at Rockefeller University. The molecular image of the toxin, published in the May 27 issue of the journal Nature, shows exactly how the toxin is put together at the molecular level and damages human DNA. The structure also could help scientists to design new drugs to fight the wide variety of bacteria that use this toxin. More »

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