Tag Archives: DNA replication

Study reveals the structure of a protein crucial for DNA replication

Study reveals the structure of a protein crucial for DNA replicationFor life to propagate, the instructions in our DNA must be copied and passed on to future generations. Focusing on the structure of the machinery that executes this process, scientists have revealed that the orientation of the proteins involved is different from what has previously been reported. More »

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In the News – Newsday – O’Donnell

Researchers at Brookhaven lab, Stony Brook and Rockefeller universities make new discoveries about double helix copying   “In Manhattan, Michael O’Donnell, who heads Rockefeller’s Laboratory of DNA Replication, said the finding will change how students understand DNA replication. ‘It’s a … More »

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Study reveals the architecture of the molecular machine that copies DNA

Study reveals the architecture of the molecular machine that copies DNAUntil now, the exact configuration of the replisome, a block of proteins that unzips the DNA helix and creates two duplicate helices, was unknown. After taking the first complete pictures of it, researchers were surprised to find the complex possesses a counterintuitive architecture, raising new questions about its functions. More »

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Researchers create the first model of the DNA ‘replication fork’

Researchers create the first model of the DNA ‘replication fork’This new tool promises to allow scientists to explore the as-yet-unknown details of how cells unzip the double-stranded DNA molecule and replicate it, a process crucial to life. More »

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Scientists crash test DNA’s replication machinery

Important molecular machines routinely crash into one another while plying their trades on DNA. New research shows that the enzymes that copy DNA before cell division, called replisomes, are the kings of this road, kicking aside machines that are performing less critical tasks, such as transcribing instructions for proteins. More »

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Molecule stops DNA replication in its tracks

When a dividing cell duplicates its genetic material, a molecular machine called a sliding clamp travels along the DNA double helix, tethering the proteins that perform the replication. Rockefeller University scientists have discovered a small molecule that stops the sliding clamp in its tracks, a finding that will enable researchers to better study the proteins that duplicate DNA, and may ultimately provide a platform for developing improved antibiotics. More »


Critical protein prevents damaged DNA from persisting through generations

When B lymphocytes lack the ATM protein, chromosomal breaks created during their maturation go unrepaired, and checkpoints that normally prevent the damaged cell from replicating are lost. More »

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New study reveals inner workings of a molecular clamp critical to DNA replication

The process by which DNA is copied, an essential biological function which occurs millions of times a day in an average mammal, is driven by three core protein complexes. New research from Rockefeller University now shows that one of these complexes, a “clamp loader,” requires several previously unidentified steps to get the process started. More »

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With no plan for DNA replication, cells depend on random selection

New research in yeast from Rockefeller University shows that instead of going about DNA replication in an organized way, the cell takes a random approach, using a range of efficient and inefficient origins. The results leave scientists wondering how the cell ensures that the process is completed on time. More »

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‘Hitchhiking’ chromosomes yield new theory of cell division

From the moment the cell was discovered, scientists have been dissecting the methodical, multi-step process by which they duplicate themselves. This week, Rockefeller researchers studying one component of this process — how a cell’s chromosomes move in preparation for division — announce a discovery that overturns current cell-division theory. More »

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Clearing jams in the copy machinery

Bacteria and humans use a number of tools to direct perhaps the most important function in cells — the accurate copying of DNA during cell division. Now, Rockefeller scientists show that one of these proteins, the beta sliding clamp, serves as a toolbelt, from which the correct proteins are retrieved to enable DNA replication in the face of DNA damage. More »

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Rockefeller researchers identify new role for key protein that regulates separation of DNA in dividing cells

Rockefeller University scientists have revealed a new function of a key component of the mechanism that cells use to accurately separate chromosomes when they divide. Disruptions in this process can cause diseases such as cancer. More »

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