Tag Archives: Elaine Fuchs

Scientists discover an unexpected influence on dividing stem cells’ fate

Scientists reveal an unexpected influence on dividing stem cells' fateWhen it divides, a stem cell has a choice: produce more stem cells or turn into the specific types of cells that compose skin, muscle, brain, or other tissue. New experiments in skin show this decision can be altered if tiny organs within cells aren’t positioned and divvied up properly. More »

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Researchers explore how protein production gets distorted in skin cancer

Researchers explore how protein production gets distorted in skin cancerResearchers have shown that a shift in translation, the process by which cells produce proteins from RNA, may promote skin cancer. The discovery could potentially aid the development of new treatments.
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Elaine Fuchs wins 2017 McEwen Award for Innovation

Elaine Fuchs wins 2017 McEwen Award for InnovationFuchs has received the 2017 McEwen Award for Innovation. The prize, given by the International Society for Stem Cell Research, recognizes outstanding contributions in the fields of stem cell research or regenerative medicine. Fuchs will receive a $100,000 award and present her research at the society’s annual meeting in June. More »

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Research on sweat glands suggests a route to better skin grafts

Research on sweat glands suggests a route to better skin graftsScientists have discovered the signaling pathways that help hair follicles and sweat glands form during development, and identified the mechanism that allows both of these features to coexist in human skin. The findings may improve the methods used to grow tissue used in grafting procedures.
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Elaine Fuchs to receive 2016 Vanderbilt Prize in Biomedical Science

Elaine Fuchs to receive 2016 Vanderbilt Prize in Biomedical ScienceThe prize, given by Vanderbilt University School of Medicine, recognizes women with outstanding research accomplishments who have also made significant contributions to mentoring other women in science. Fuchs is being honored for her innovative use of reverse genetics to understand skin diseases and cancer stem cells. More »

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New research clarifies why wounds heal more slowly with age

New research clarifies why wounds heal more slowly with age With age, it takes longer for skin cells to close an injury. New research shows that a breakdown in communication between these cells and neighboring immune cells causes this delay—a discovery that has implications for improving healing among older people. More »

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New research clarifies how stem cells get activated to produce new hair—and what happens when their regenerative powers wear out

New research clarifies how stem cells get activated to produce new hair—and what happens when their regenerative powers wear outStem cells residing in hair follicles are held in an inactive state for long periods of time. A new study shows that these quiescent periods are essential for maintaining the cells’ rejuvenating activity over time, and clarifies the mechanisms that bring the cells in and out of quiescence. More »

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Study identifies signals that make early stem cells

Study identifies signals that make early stem cellsWhere and when do stem cells first appear during development? Researchers investigated this question by examining how cells organize as the hair follicle first appears in mouse embryos. They uncovered signaling pathways that may provide insights into some skin cancers. More »

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Postdoc Shruti Naik wins Regeneron Prize for Creative Innovation

Postdoc Shruti Naik wins Regeneron Prize for Creative InnovationAwarded by Regeneron Pharmaceuticals, Inc., the prize recognizes innovative young scientists based on proposals they submit that have the potential to drive biomedical research forward. Naik proposed using stem cell-based therapies to treat inflammatory diseases, such as psoriasis, chronic pulmonary obstructive disease, and inflammatory bowel disease. More »

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Elaine Fuchs wins cell biologists’ highest honor

Elaine Fuchs wins cell biologists’ highest honorIn recognition of her pioneering research on mammalian skin and adult stem cells, Fuchs has received the E.B. Wilson Medal, the highest scientific honor bestowed by the American Society for Cell Biology. The medal will be presented at the society’s annual meeting in California on December 15. More »

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Scientists pinpoint molecule that controls stem cell plasticity by boosting gene expression

Scientists pinpoint molecule that controls stem cell plasticity by boosting gene expressionExperiments placed Sox9 at the crux of a shift in gene expression associated with hair follicle stem cell identity. The molecule first makes stem cell genes accessible so they can become active, then recruits other molecules that promote the expression of these genes in stem cells found at the base of the hair follicle. More »

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Growth signal can influence cancer cells’ vulnerability to drugs, study suggests

Growth signal can influence cancer cells’ vulnerability to drugs, study suggestsResearchers found that exposure to the signal TGF-β causes changes in mouse tumor stem cells that help them evade a widely used anti-cancer drug. This did not happen to cells that did not receive TGF-β. More »

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One signal means different things to stem cells versus their progeny

One signal means different things to stem cells versus their progenyWhen researchers shut down hair follicle stem cells’ ability to respond to a protein, the cells began dividing prematurely. Meanwhile, when the same was done to their progeny cells, the fate of these cells shifted. More »

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Daniel Schramek awarded Regeneron Prize for Creative Innovation by a Postdoctoral Fellow

Schramek, one of just two individuals receiving the annual award, is being recognized for his proposal of a project that used sequence-based personalized medicine to treat the most devastating features of cancer. The award comes with a $50,000 prize and a $5,000 donation to support seminars at Rockefeller. More »

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Stem cell progeny tell their parents when to turn on

Hsu-follicle-vertical-05052014During an infection, the immune system selects B cells that produce antibodies with a high affinity for the pathogen. New research helps explain the details of how these cells are selected and amplified. More »

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Elaine Fuchs receives prestigious award from American Association for Cancer Research

Fuchs is being recognized with the 2014 Pezcoller Foundation-AACR International Award for Cancer Research for her contributions to the understanding of skin, skin stem cells and skin-related disease. Fuchs is highly regarded for her studies using reverse genetics to understand the biological basis of normal and abnormal skin development and function. The award, now in its 17th year, recognizes an individual scientist of international renown who has made a major scientific discovery in basic or translational cancer research. More »

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New RNA interference technique finds seven genes for head and neck cancer

The technique, created by scientists in Rockefeller’s Laboratory of Mammalian Cell Biology and Development, attaches short pieces of RNA to highly concentrated viruses and uses ultrasound to inject the viruses into mouse embryos. It takes a fraction of the resources and much less time than using knockout mice to conduct genetic screens, and can assess about 300 genes in a single mouse in as little as five weeks. More »

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New technique in RNA interference cuts time and cost in genetic screens

Rockefeller scientists revealed the first genome-wide RNA interference screen of a mouse, using a new technique that essentially treats the surface of living mouse embryos as a petri dish of cells, allowing for in vivo analysis. More »

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Researchers find molecule that causes sunburn pain

A collaboration between Elaine Fuch’s Laboratory of Mammalian Cell Biology and Development at Rockefeller University and researchers at Duke University and the University of California, San Francisco, found that blocking a molecule called TRPV4 greatly protects against the painful effects of sunburn. The research could yield a way to combat sunburn and possibly several other causes of pain. More »

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Scientists identify gene that regulates stem cell death and skin regeneration

A collaboration between researchers in Hermann Steller’s Strang Laboratory of Apoptosis and Cancer Biology and Elaine Fuchs’s Laboratory of Mammalian Cell Biology and Development has revealed a new function for a gene previously shown to prevent stem cells from turning cancerous. The gene, Sept4/ARTS, has now been shown to regulate programmed death in skin stem cells, a finding that may have implications for wound healing, regeneration and cancer. More »

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