Tag Archives: gene activation

Structure shows how a key protein in gene activation is controlled

Using the structure of the protein σ28 bound to its inhibitor as inspiration, a new structural study finds that this gene activator can also inhibit itself from binding to and expressing the wrong gene at the wrong time. More »

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Rockefeller University researchers identify protein modules that “read” distinct gene “silencing codes”

Since the time when humans first learned to record their thoughts in written form, codes have kept sensitive information from prying eyes. But conveying information through a code requires someone who can read it as well as write it. The same is true for one of nature’s methods for transmitting information that activates or silences a gene: the “histone code.” More »

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Rockefeller Receives Horwitz Prize for Pioneering Work on How Genes are Turned On and Off

Rockefeller University biochemist Robert Roeder, Ph.D., received the Louisa Gross Horwitz Prize from Columbia University on Thursday, Feb. 3. The prize, which Roeder shares with Robert Tjian, Ph.D., of the Howard Hughes Medical Institute at the University of California at Berkeley and Pierre Chambon, M.D., of the Université Louis Pasteur and the College de France, honors scientists for “outstanding basic research in biology or biochemistry.” More »

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