Tag Archives: genetics and genomics

A new way to reset gene expression in cancer cells shows promise for leukemia treatment

A protein that often is mutated in leukemia cells could represent a potent drug targetScientists have discovered a potential new target for the treatment of leukemia that potentially could augment the activity of BET inhibitors, drugs currently in clinical trials. These therapies act on histones, DNA’s packaging proteins, to reset gene regulatory programs that go awry in cancer.
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Genomic testing could speed research on skin disease and bring new drugs to patients faster

Mayte Suarez-Farinas and Joel Correa da Rosa in Greenberg BuildingWhen a person suffering from psoriasis starts taking a new therapy, it can currently take months to assess if the drug is working. But according to a recent study, that process could be significantly sped up with genomic testing and analysis. More »

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Researchers find combined effects of two genes responsible for premature skull fusion in infants

Researchers identify mutations responsible for premature skull fusion in infantsA combination of rare and common genetic variants can cause the bones at the top of the head to unite prematurely, resulting in deformities and, in some cases, neurodevelopmental problems. This discovery will help to diagnose the condition and identify families at risk, while advancing the understanding of complex genetic traits. More »

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Researchers uncover how “silent” genetic changes drive cancer

New insights into muscular dystrophy point to potential treatment avenuesSmall molecules called tRNA, whose job is to help translate genes into proteins, are not usually considered important for understanding the causes of disease. But a new study shows that fluctuations in some tRNAs may in fact influence the progression of breast cancer. More »

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Scientists find evidence that cancer can arise from changes in the proteins that package DNA

Scientists find evidence that cancer can arise from changes in the proteins that package DNAMutations in histones, the proteins that shield and package DNA, have been linked to many types of cancer, but their role in promoting disease has not been clear. Now, for the first time, scientists have found that a change to the structure of a histone can trigger a tumor on its own. More »

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Jean-Laurent Casanova honored with the Korsmeyer Award

Jean-Laurent Casanova honored with the Korsmeyer AwardJean-Laurent Casanova is the recipient of the 2016 Stanley J. Korsmeyer Award. The award recognizes Casanova for discovering that vulnerability to life-threatening infectious illnesses in otherwise healthy children and young adults can arise from single-gene inborn errors. More »

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Widespread skewed expression of mRNA components correlate with fine tuning of protein production

Widespread skewed expression of mRNA components correlate with fine tuning of protein productionIn numerous tissues and genes, the researchers found lopsided ratios in two parts of mRNA transcripts of genes, one of which carries the code for a protein and one that doesn’t. They suspect some of these skewed ratios may help control protein production, particularly in the embryo, but also in the adult. More »

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New research helps to explain how temperature shifts the circadian clock

New research helps to explain how temperature shifts the circadian clockOne important aspect of the internal time-keeping system continues to perplex scientists: its complex response to temperature, which can shift the clock forward or backward, but cannot change its 24-hour period. New experiments help explain how this is possible. More »

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Helen Hobbs will receive the 2015 Pearl Meister Greengard Prize

Helen Hobbs will receive the 2015 Pearl Meister Greengard PrizeHobbs, of the University of Texas Southwestern Medical Center and the Howard Hughes Medical Institute, is being recognized for her work on the genetic determinants of plasma lipoprotein levels and risk for cardiovascular disease. The prize is intended to honor the extraordinary work of established women scientists and to motivate young women considering careers in the sciences. More »

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Research identifies a protein that helps determine the fate of RNA

Research identifies a protein that helps determine the fate of RNARNA can be translated into protein or turned into gene-regulating molecules. A newly discovered “reader” recognizes a chemical instruction tag affixed to RNA, an important step in determining the RNA’s destiny. Because of the processes involved, the research has implications for cells’ normal function and disease. More »

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Promising class of new cancer drugs causes memory loss in mice

Promising class of new cancer drugs causes memory loss in miceNew research shows that a family of experimental cancer drugs can induce neurological changes in mice. The findings underscore the need for more research to determine whether these compounds can enter the brain, where they potentially might cause side effects such as memory loss. More »

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