Tag Archives: Günter Blobel

Study suggests new way to help the immune system fight off sleeping sickness parasite

Study suggests new way to help the immune system fight off sleeping sickness parasiteThere are currently few treatments for the disease, and those that exist have substantial side effects. A new study reveals a method, involving epigenetic mechanisms, that causes the African sleeping sickness parasite to change into a new state, potentially making it easier for the host immune system to eliminate it. More »

Tags: , , , , , , , ,

Research reveals key interaction that opens the channel into the cell’s nucleus

Research reveals key interaction that opens the channel into the cell’s nucleusScientists have uncovered crucial steps in the dynamic dance that dilates and constricts the nuclear pore complex. Their ongoing work has shown this elaborate portal to and from the cell’s nucleus is much more than the inert structure it was once thought to be. More »

Tags: , , , ,

Atomic map reveals clues to how cholesterol is made

Atomic map reveals clues to how cholesterol is madeAn enzyme embedded in the cell membrane performs a crucial step in the complex process by which cells produce cholesterol. Researchers have examined the enzyme’s structure to better understand how it works. More »

Tags: , , , ,

Polarized microscopy technique shows new details of how proteins are arranged

A key component of the nuclear pore complex — a Y-shaped cluster of proteins that helps determine what gets in and what stays out of a cell’s nucleus — was first photographed and modeled at Rockefeller in 2009. But fundamental questions about how the structures were aligned in relation to the rest of the 30-protein complex remained. Researchers at Rockefeller University have now developed a new technique that uses polarized light microscopy to help answer questions about the proteins’ orientation. More »

Tags: , , , ,

Research identifies 3D structure of key nuclear pore building block

New research into the molecular machine that filters all information traveling in or out of the cell nucleus contributes to an unfolding picture of cellular evolution that shows a common architecture for the nuclear pore complex (NPC) and the vehicles that transport material between different parts of the cell. Scientists have for the first time glimpsed in three dimensions the subcomplex of the NPC that is its key building block. More »

Tags: , ,

New model of a nuclear pore complex is based on crystal structure of its key component

In the second nuclear pore study to come out of Rockefeller University in as many months, researchers have determined the crystal structure of one of the pore’s main components. Using that shape as their base, they propose an overall structure for the circular pore: rings of alternating protein complexes that fit together like two sides of a zipper. More »

Tags: , ,

Building the nuclear pore piece by piece

Because the nuclear pore is the only way in or out of the nucleus, the cell is in dire straits when the pore malfunctions, as in forms of leukemia where nuclear pore complex proteins are mutated. Two new structural renderings of nuclear pore complex proteins, however, created in the Nobel Prize-winning lab that has worked for nearly 40 years on understanding how proteins are transported within cells, are beginning to shed light on this puzzling assembly. More »

Tags: , ,

The protein’s in the mail

A busy urban post office daily sorts thousands of letters and parcels, guiding each to a particular mailbox somewhere in the city. Each day, every cell of the human body manufactures millions of proteins which it also must continually sort and route to their final destinations within the cell. Only when a protein has reached its destination can it do its assigned work. More »

Tags: , ,

NYC pilot study pushes Human Genome Project toward cures for disease

With the completion of the Human Genome Project (HGP) in sight, a group of New York City scientists are undertaking a strategic pilot study to turn that knowledge into promising drug targets as quickly as possible. More »

Tags: , ,

Nobel Laureate Blobel to Give First Medicine Prize Lecture Live Online

The first live Webcasts of the Nobel Prize lectures will take place on Wed., Dec. 8, 1999. This year’s laureate in Physiology or Medicine, Günter Blobel, M.D., Ph.D., of The Rockefeller University, will present his lecture, “Protein Targeting.” More »

Tags: ,

Rockefeller University Cell Biologist, Günter Blobel, Wins 1999 Nobel Prize in Medicine

Rockefeller University cell biologist Günter Blobel, M.D., Ph.D., was awarded the 1999 Nobel Prize in Physiology or Medicine today. Blobel, the John D. Rockefeller Jr. Professor at The Rockefeller University and a Howard Hughes Medical Institute investigator, heads the Laboratory of Cell Biology. More »

Tags: ,