Tag Archives: hepatitis C

In the News – New York Times – Rice

Lasker Awards Given for Work in Physiology, Virology and Science Education   “At the time, researchers thought the work might be as simple as inserting that newly sequenced RNA into cultured cells and watching it replicate. But in experiment after … More »

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Charles M. Rice wins Lasker Award for groundbreaking work on the hepatitis C virus

Charles M. RiceThis year’s Lasker-DeBakey Clinical Medical Research Award honors Charles M. Rice, who developed a system to study the replication of the virus that causes hepatitis C, an advance that has led to safe and powerful new drugs that cure the disease. The award, considered the most coveted American prize in medical science, will be presented on September 23 in New York City. More »

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Charles Rice wins Belgium’s highest scientific prize

Charles Rice wins Belgium’s highest scientific prizeRice has received the 2016 InBev-Baillet Latour Health Prize for his fundamental discoveries in the field of infectious diseases. The award, given by the Baillet Latour Fund to recognize outstanding contributions in biomedical research for the benefit of human health, is Belgium’s most important scientific prize. More »

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Expression of a single gene lets scientists easily grow hepatitis C virus in the lab

Expression of a single gene lets scientists easily grow hepatitis C virus in the labIn devising a method to readily grow hepatitis C in the laboratory, scientists might have overcome a major hurdle for basic research into the virus and the disease it causes.
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Study details microRNA’s role as a double agent during Hep C infection

Study details microRNA’s role as a double agent during Hep C infectionBoth the virus and liver cells need the microRNA molecules the liver produces to regulate its genes. Researchers found that by co-opting one microRNA, the virus may cause changes in gene expression in liver cells. More »

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Scientists create humanized mouse model for hepatitis C

A team of researchers led by scientists in the Laboratory of Virology and Infectious Disease at Rockefeller have, for the first time, recreated a portion of the hepatitis C virus life cycle in a mouse with a functional immune system. The new mouse model will enable scientists to test molecules that block entry of the hepatitis C virus into cells as well as potential vaccine candidates. More »

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Rockefeller virologists and MIT tissue engineers receive $5.8 million NIH grant to study hepatitis

Provided through the National Institutes of Health’s inaugural Transformative R01 grant program — a groundbreaking initiative designed to encourage high-risk research — the grant will run for five years and will fund efforts to elucidate the notoriously complex mechanisms underlying hepatitis B and C virus infection. More »

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Discovery could lead to a new animal model for hepatitis C

The hepatitis C virus is interested in only one thing: human liver cells. That has been one of scientists’ greatest frustrations in their efforts to study the virus, and has hampered the development of useful animal models for the disease. But now, in a major leap forward, scientists have identified a protein that allows this uniquely human pathogen to enter mouse cells, a finding that could lead to a vaccine or to new treatments. More »

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By imaging living cells, researchers show how hepatitis C replicates

The hepatitis C virus is a prolific replicator, able to produce up to a trillion particles per day in an infected person. By using live imaging, researchers now know how. Their research shows that within an infected cell, the virus uses a combination of big viral factories and tiny, mobile replication complexes to efficiently churn out copies. More »

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New theory suggests how hepatitis C may cause rare immune disease

In 1990 researchers observed that most patients with hepatitis C also develop a rare autoimmune disease called mixed cryoglobulinemia, a condition that frequently leads to cancer, arthritis or both. Now scientists at Rockefeller University say that a decade-old explanation of how one disease causes the other is likely wrong, and instead offer a new — albeit controversial — theory of their own. More »

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Hepatitis C virus blocks ‘superinfection’

There’s infection and then there’s superinfection – when a cell already infected by a virus gets a second viral infection. But some viruses don’t like to share their cells. New research from Rockefeller University shows that the hepatitis C virus, which infects cells in the liver and can cause chronic liver disease, can block other hepatitis C variants from infecting the same cell. More »

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Kety protein for Hepatitis C entry identified

For as many as 200 million people worldwide infected with hepatitis C, a leading cause of chronic liver disease, treatment options are only partially effective. But new research by Rockefeller University scientists points to a potential new target for better drugs: a key protein that resides in human liver cells that hepatitis C requires for entry. More »

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Researchers show laboratory hepatitis C strain is also infections in animal models

For many years scientists have struggled with an inability to efficiently culture the hepatitis C virus in the laboratory. Now, researchers at Rockefeller University have overcome several obstacles and successfully shown that a strain of HCV they created in the laboratory, which can efficiently be cultured in vitro, is also infectious in animals. More »

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Researchers create infectious hepatitis C virus in a test tube

New system will allow scientists to study every stage of the HCV life cycle and develop drugs to treat this life-threatening disease. More »

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Researchers Identify Key to Genetic Replication in Hepatitis C Virus

Researchers at Rockefeller University and Washington University School of Medicine in St. Louis have identified mutations in a protein of certain strains of hepatitis C virus (HCV) that allow these strains to replicate more vigorously in human cell culture. The finding allows scientists to improve an essential tool for studying the virus and suggests a starting point for the design of effective vaccines. More »

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First Hepatitis-C Center in Northeast Region Established By Rockefeller University, New York-Presbyterian, and Weill Cornell

New York, NY–Three neighboring New York City medical institutions–The Rockefeller University, NewYork-Presbyterian Hospital, and Weill Medical College of Cornell University–have jointly established the Center for the Study of Hepatitis C, the first major center in the Northeast region devoted specifically to the disease. Renowned virologist Charles M. Rice, Ph.D., who recently made the first infectious clone of the virus, will join The Rockefeller University faculty and serve as both scientific and executive director of the multi-institutional center. More »

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