Tag Archives: histone code

Influenza “histone mimic” suppresses antiviral response

Researchers have discovered a novel mechanism by which influenza viruses hijack key regulators of the human body’s normal antiviral response in order to slip by it undetected. The results have major implications for our understanding of the biology of the seasonal influenza virus and suggest a possible target for a new class of antiviral and anti-inflammatory drugs. More »

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Scientists develop a tool to study deadly parasite’s histone code

In a genome-wide study, scientists are the first to map the epigenetic changes that are likely to play a role in the molecular origami of transcription initiation in Trypanosoma brucei, the deadly single-celled parasite responsible for African sleeping sickness. More »

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Scientists confirm a molecular clipping mechanism behind stem cell development

Some genes are regulated through a process by which proteins in the cell nucleus, called histones, are chemically modified by small “chemical marks.” New research from Rockefeller University scientists shows that during specific stages of differentiation in mouse embryonic stem cells, crucial marks can be removed by cutting off the end of the histone’s tail. More »

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Core tenets of the “histone code” are universal

Histones, specialized proteins that package and control DNA, rely on a code to regulate gene transcription. Certain chemical modifications at histone tails act like a code that signals genes to turn on or off. Rockefeller University scientists show that nonhistone proteins recognize features of this histone code, and reveal an instance of histone mimicry. More »

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Beyond epigenetics

Rockefeller University scientists now have moved a step beyond epigenetics in describing how genetically driven activities are carried out. Working with an important molecule, called Ezh2, known to alter histones in the cell nucleus, Sasha Tarakhovsky, Ph.D., and his colleagues have discovered a new type of signaling system in the cytosol, the fluid or jelly-like substance outside of a cell’s nucleus. More »

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Rockefeller University researchers identify protein modules that “read” distinct gene “silencing codes”

Since the time when humans first learned to record their thoughts in written form, codes have kept sensitive information from prying eyes. But conveying information through a code requires someone who can read it as well as write it. The same is true for one of nature’s methods for transmitting information that activates or silences a gene: the “histone code.” More »

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Frog (and histone) tails tell the tale

Using laboratory cultures of human leukemia cells and the tails of tadpoles, a Rockefeller University researcher has shown that specialized proteins in the cell nucleus contain chemical flags that provide a “code” that spells death. More »

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More Than Just Packaging, Histones Help Turn Genes On

Histones, the proteins that help roll several feet of DNA into the microscopic span of a single nucleus, are turning out to be much more than just packaging material. Instead, recent studies indicate that these once underrated proteins actively participate in switching genes “on” — a vital life process occurring at all times in each one of our cells. More »

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