Tag Archives: histones
Allis’s discovery that chemical “tags” bind to specific sections of histone proteins in order to activate or silence nearby genes has ignited the field of epigenetics, a relatively new area of study which explores the inheritance of physical changes that cannot be traced back to mutations in the DNA sequence. The Japan Prize, worth approximately half a million dollars, is among the most prestigious prizes in science. More »
Scientists in David Allis’s laboratory have shown how a mutated histone protein inhibits an enzyme, which normally keeps cell growth in check, and causes a rare form of pediatric brain cancer called DIPG. Their findings reveal a mechanism for inhibiting enzymes and could lead to the development of pharmaceuticals that mimic the action of these mutant proteins.
Allis leads one of five cancer research teams that are winners of $5 million in grant awards from The Starr Foundation’s Sixth Starr Cancer Consortium Grant Competition.
Researchers have discovered a novel mechanism by which influenza viruses hijack key regulators of the human body’s normal antiviral response in order to slip by it undetected. The results have major implications for our understanding of the biology of the seasonal influenza virus and suggest a possible target for a new class of antiviral and anti-inflammatory drugs. More »
Histones, the proteins that help roll several feet of DNA into the microscopic span of a single nucleus, are turning out to be much more than just packaging material. Instead, recent studies indicate that these once underrated proteins actively participate in switching genes “on” — a vital life process occurring at all times in each one of our cells. More »