Tag Archives: HIV

Encouraging clinical results for an antibody drug to prevent or treat HIV

Encouraging results for an antibody drug to prevent or treat HIVA drug known as 10-1074, based on a human antibody against HIV, has dramatically reduced virus levels in patients and appeared to prevent infection among those at high risk, according to data from a new clinical trial. More »

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Antibody Combination Puts HIV on the Ropes

Antibody combination puts HIV on the ropesResearchers have shown that a combination of three antibody drugs can completely suppress HIV in infected mice. The antibodies were isolated from a patient whose immune system mounted an unusually effective response against the virus. More »

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New antibody drug continues to show promise for treatment of HIV

New antibody drug continues to show promise for treatment of HIVAntibody therapy may offer an alternative to standard HIV treatments, which require a strict regimen and can cause complications in the long-term. New results from a clinical trial show that the 3BNC117 antibody can significantly delay the virus from rebounding in patients taken off their current medications. More »

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In the News – Los Angeles Times – Nussenzweig

New therapy keeps HIV at bay without daily drug regimen, study says   “Using antibodies against HIV could be part of a ‘kick and kill’ strategy, said study co-author Dr. Michel Nussenzweig — to kick the virus out of its … More »

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Michel C. Nussenzweig honored with the 2016 Robert Koch Award

Michel C. Nussenzweig honored with the 2016 Robert Koch AwardGiven by the Robert Koch Foundation, the annual award is one of Germany’s most prestigious scientific prizes, honoring extraordinary accomplishments in infectious disease research. Nussenzweig will share the €100,000 prize with Alberto Mantovani of Humanitas University for their achievements in immunology. More »

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New method gives scientists a better look at how HIV infects and takes over its host cells

New method gives scientists a better look at how HIV infects and takes over its host cellsA research team wanted to know how HIV uses its tiny genome to manipulate our cells, gain entry, and replicate—all while escaping the immune system. They’ve spent a decade developing an experimental approach that finally is yielding answers. More »

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Antibody therapy opens door to potential new treatment for HIV

Antibody Therapy Opens Door to Potential New Treatment for HIVResearchers are developing an antibody-based drug that may provide a better strategy for long-term control of HIV. New results from a clinical trial suggest that a single dose of a so-called broadly neutralizing antibody enables patients’ immune systems to better fight the virus. More »

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In the News – BBC – Nussenzweig

HIV: new approach against virus “holds promise”   “Michel Nussenzweig of The Rockefeller University told BBC News: ‘This is different to treatment out there already on two counts. First because it comes from a human – so it is natural … More »

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In first human study, new antibody therapy shows promise in suppressing HIV infection

In first human study, new antibody therapy shows promise in suppressing HIV infectionIn the first results to emerge from HIV patient trials of a new generation of so-called broadly neutralizing antibodies, Rockefeller University researchers have found the experimental therapy can dramatically reduce the amount of virus present in a patient’s blood. The work, reported this week in Nature, brings fresh optimism to the field of HIV immunotherapy and suggests new strategies for fighting or even preventing HIV infection. More »

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Research captures transient details of HIV genome packaging

Researchers have employed a recently developed technique to capture how a viral protein, Gag, selectively extracts and packages viral RNA into the viral particles that exported to new cells. More »

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In the News – GlobeAndMail – Nussenzweig

HIV: Latent reservoir of virus in rare immune cells could help develop cure “Research at Rockefeller University suggests that a quiet body of immune cells that do not divide could harbour a reserve of HIV virus, a potential target for … More »

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Long-acting drug effectively prevents HIV-like infection in monkeys

Long-acting drug effectively prevents HIV-like infection in monkeysBecause cabotegravir would require only one injection every three months, researchers hope this new drug, which has begun clinical testing, could improve some patients’ ability to take HIV prevention medication properly. More »

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Antibodies, together with viral ‘inducers,’ found to control HIV in mice

Antibodies, together with viral ‘inducers,’ found to control HIV in miceA new strategy devised by researchers at Rockefeller University harnesses the power of broadly neutralizing antibodies, along with a combination of compounds that induce viral transcription, in order to attack latent reservoirs of HIV-infected cells in an approach termed ‘shock and kill.’ More »

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Potent antibodies neutralize HIV and could offer new therapy, study finds

Rockefeller researchers in Michel Nussenzweig’s Laboratory of Molecular Immunology have found that a newly-discovered class of especially potent antibodies is effective at neutralizing HIV infection in mice for a 60 day period, longer than current antiretroviral drugs which require daily application. The antibodies, which suppressed the virus when used in combination, could one day be given to humans to treat the disease. More »

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Johannes Scheid wins 2012 Weintraub Graduate Student Award

Scheid is one of 13 awardees, all advanced graduate students at or near the completion of their studies in the biological sciences and chosen for the quality, originality and significance of their thesis research.
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Research on killer HIV antibodies provides promising new ideas for vaccine design

By detailing the molecular workings of broadly neutralizing anti-HIV antibodies, found in so-called slow-progressing HIV patients, researchers hope to devise a way to arm those who are not equipped with exceptional immunological firepower. New clues reveal that some anti-HIV antibodies are especially sticky and target a previously unrecognized part of the virus. More »

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Immune system uses a “leash” to restrict HIV’s spread

New research shows how an antiviral protein, tetherin, lashes newborn viral particles to infected cells, slowing the spread of infection. Understanding how this immune system defense works against HIV, Ebola and other deadly viruses could lead to better antiviral therapies. More »

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A natural approach for HIV vaccine

Since HIV was first recognized in the early 1980s, scientists have tried and failed to develop a vaccine based on a handful of “super antibodies” that so far have been impossible to produce in humans. Now new research detailing the dynamic, natural immune response in “slow-progressing” HIV patients suggests that an effective HIV vaccine may come from a shotgun approach targeting several parts of the virus rather than a magic bullet targeting only one. More »

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Researchers unveil new monkey model for HIV

For the first time, scientists have succeeded in engineering a strain of HIV-1 that they can study in monkeys. Just one gene different from the deadly retrovirus that works all too well in humans, the new strain spreads in pig-tailed macaques almost as ferociously as it does in humans. Researchers at The Rockefeller University have already used it to demonstrate one method for preventing HIV-1 infection. With some minor changes, it could become a valuable model for vetting vaccine candidates. More »

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Scientists image a single HIV particle being born

For some, the saying “seeing is believing” has taken on a new meaning. In research to be published in the May 25 advance online issue of Nature, scientists at Rockefeller University and the Aaron Diamond AIDS Research Center have become the first to see, in real time and in plain sight, an HIV particle being born. The images, created using a technique that illuminates only the surface of the cell, where the virus assembles, have the potential to help researchers develop new treatments for AIDS. More »

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