Tag Archives: James E. Darnell Jr.
The society, founded by Benjamin Franklin in 1743, it is the United States’ first learned society, and unique among its peers for the wide variety of academic disciplines represented by its membership. Darnell is the university’s tenth faculty member to be inducted into the society. More »
Praised as “towering figures” in cell research, the scientists are being recognized for helping to define how cells grow, replicate, and become specialized, and in turn giving medical professionals and researchers the tools to improve health and combat diseases. James E. Darnell Jr., head of the Laboratory of Molecular Cell Biology, and Robert G. Roeder, head of the Laboratory of Biochemistry and Molecular Biology, will share the $500,000 prize from the 12th annual award, given at a May 11 ceremony in Albany, NY.
Beginning with the molecular origins of life and culminating with the latest findings on human evolution, 18 of the world’s leading experts will report on research spanning three billion years of evolution. More »
James E. Darnell Jr., M.D., a pioneering researcher in the field of gene regulation, will receive the National Medal of Science, the White House announced today. Darnell is among eight American scientists to receive the award, the nation’s highest honor for lifetime achievement in fields of scientific research. More »
Researchers may be looking for novel cancer drugs in the wrong places, says Rockefeller University Professor James E. Darnell Jr., M.D., in an article in this month’s Nature Reviews Cancer. More »
James E. Darnell Jr., M.D., the pioneering researcher in the field of gene regulation — who has nurtured the careers of over 100 young, talented scientists — was honored today with the 2002 Albert Lasker Award for Special Achievement in Medical Science. More »
When the Human Genome Project first revealed last year that humans possess only an estimated 30,000 genes — fives times more than a mustard weed plant — the fact that many of our genes code for more than just one protein assumed greater importance. Such protein variations, researchers reasoned, must play an even larger role than previously thought in contributing to the remarkable complexity of human beings. More »
Fifty years ago, in the early days of biology, so little was known about the cell that all of the proteins outside of its nucleus were grouped into one big “cytoplasmic soup.” Now, as the list of known cellular ingredients continues to expand beyond the capacity of any recipe card, two Rockefeller University scientists are taking a step back to ask whether there might be a better way to organize the current thinking about a particularly important class of proteins inherent to all living cells. More »
Malignant Cells Survive-and Replicate-Because Cancer-causing Molecule Jams Normal p53 Cell-suicide Trigger
A cancer-causing molecule called WISP-1 may explain why some people with cancer do not benefit from chemotherapy while others with the same form of cancer respond to the treatment, according to researchers at The Rockefeller University. The findings, reported in the Jan. 1 issue of Genes and Development, suggest that drugs designed to block WISP-1 may increase the effectiveness of chemotherapy in colon cancer and perhaps other cancers. More »
Scientists at The Rockefeller University have found, for the first time, that the persistent activation of a protein called Stat3 can, by itself, cause normal cells to behave like cancer cells. The research, reported in the August 6 issue of Cell, provides both a scientific surprise and a promising new target in the fight against cancer. Scientists already knew that Stat3 was often activated in various human cancer types, including lymphomas, leukemias, breast cancer and a high percentage of head and neck cancers, but until now no one knew whether persistent Stat3 activation could contribute directly to the development of tumors. More »