Tag Archives: Jan L. Breslow

Vitamin D supplements do not improve cholesterol as previous research suggested

A team of scientists has shown that, at least in the short term, cholesterol levels did not improve when volunteers with vitamin D deficiency received mega-doses of vitamin D. Although previous evidence suggested there might be a link between vitamin D and heart disease, the clinical results confirm those from a data mining study published in July. More »

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Clinical trial to explore link between vitamin D and cholesterol

An unusual finding in previous studies of vitamin D-deficient patients has prompted a new clinical study at The Rockefeller University Hospital. Investigator Manish Ponda aims to discover if there is a causative relationship between vitamin D supplementation and elevated levels of small LDL cholesterol. The hospital is currently recruiting subjects for the study. More »

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Scientists reveal a new mechanism that increases atherosclerosis in mice

For all the good it does, a liver protein that senses and gets rid of drugs and pollutants from our body has a downside. For the first time, it has been shown that when it is chronically activated, the protein, called PXR, rejiggers how cholesterol is processed in the liver and increases the risk of developing atherosclerosis. The work has direct clinical consequences to patients under long-term treatment of PXR-activating drugs, including several antibiotic and anti-cancer medications — and your daily latte. More »

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Single letter in the human genome points to risk for high cholesterol

In the search for genes that affect how humans synthesize, process and break down cholesterol, a consortium of researchers led by Rockefeller University scientists has found a single letter in the genome that is associated with elevated LDL cholesterol levels, one of the leading health concerns that has come to dominate the 21st century. More »

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Chromosome linked to cholesterol absorption

Using strains of mice that only differ from each other on a small area of one chromosome, researchers identify two sets of genes important for cholesterol absorption and excretion — the balance of which is a key contributor to coronary heart disease susceptibility. More »

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Genetic studies in mice yield clues to how heart disease is inherited

Heart disease tends to run in families, and scientists have long known that genetics play an important role. Now, new research in mice, from the laboratory of Rockefeller’s Jan L. Breslow, shows that the genetics of heart disease are more complicated than previously thought. More »

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Newly discovered gene controls levels of “bad” cholesterol in mice

Heart disease researchers at Rockefeller University have discovered the function of a gene associated with high cholesterol levels in humans. Using mice as test subjects, the Rockefeller scientists determined that the gene, called Pcsk9, can decrease the number of receptors on liver cells that remove the “bad” LDL cholesterol from the blood. More »

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Genes may protect against heart disease rather than be harmful as previously thought

A genetic pathway whose activity was suspected to advance heart disease by increasing inflammation in the blood vessels and arteries feeding the heart may actually protect against it at least in laboratory mice, reports a team of Rockefeller University scientists led by Jan Breslow, M.D., in the Nov. 25 issue of Proceedings of the National Academy of Sciences. More »

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Proteins that transport cholesterol identified

Professor Jan Breslow and colleagues, including biomedical fellow Raymond Soccio, recently discovered a novel subfamily of the START domain lipid transfer proteins, which are thought to shuttle lipids such as cholesterol within cells. More »

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Rockefeller Heart Disease Study Seeks Patients

A new study at The Rockefeller University Hospital will assess the potential of a fatty acid found in fish to reduce heart attack risk. The researchers are testing the hypothesis that a daily dose of the omega-3 fatty acid known as DHA will positively alter heart disease risk factors in at-risk individuals, specifically overweight and obese people. Participants who meet certain weight and health criteria are currently being enrolled in the clinical trial. More »

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Rockefeller Researcher Jan Breslow Receives Bristol-Myers Squibb Award For Distinguished Achievement In Cardiovascular Research

Jan Breslow, M.D., head of the Laboratory of Biochemical Genetics and Metabolism at The Rockefeller University, has been selected to receive the 2000 Bristol-Myers Squibb Award for Distinguished Achievement in Cardiovascular Research. Breslow is one of seven researchers in various medical research fields to receive the award in 2000. More »

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Hunt for Early Heart Attack Genes Begins

More than 2,000 people will be enrolled in a hunt for the genetic causes that underlie “early” heart attacks that strike men and women in middle age. The study is part of the research program of the Starr Center for Human Genetics at The Rockefeller University in New York City. More »

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